Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type

Zai-jian Wang; Hui-xia Li; Jing-hua Wang; Fan Zhang

doi:10.1007/s11655-008-9001-2

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Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type

Updated：2021-08-27

- Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type
- Chinese Journal of Integrative Medicine Vol. 14, Issue 3, Pages: 185-189(2008)
- Affiliations：
  
  1. Department of Digestive Medicine, the Third Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
  2. Department of Digestive Medicine, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-008-9001-2
  CLC：
- Published：2008，
  
  Published Online：14 October 2008，
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Wang, Zj., Li, Hx., Wang, Jh. et al. Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type., Chin. J. Integr. Med. 14, 185–189 (2008). https://doi.org/10.1007/s11655-008-9001-2

Zai-jian Wang, Hui-xia Li, Jing-hua Wang, et al. Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type. [J]. Chinese Journal of Integrative Medicine 14(3):185-189(2008)
Wang, Zj., Li, Hx., Wang, Jh. et al. Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type., Chin. J. Integr. Med. 14, 185–189 (2008). https://doi.org/10.1007/s11655-008-9001-2 DOI：

Zai-jian Wang, Hui-xia Li, Jing-hua Wang, et al. Effect of Shugan Jianpi Granule (舒肝健脾颗粒) on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type. [J]. Chinese Journal of Integrative Medicine 14(3):185-189(2008) DOI： 10.1007/s11655-008-9001-2.

摘要

To evaluate the effect of Shugan Jianpi Granule (舒肝健脾颗粒

SJG) on the number of gut mucosal serotonin-positive cells (5-HT+C) in patients with irritable bowel syndrome (IBS) of stagnated Gan-qi attacking Pi (SGAP) syndrome type. Twenty-four patients were randomized equally into three groups. All were treated with the basic conventional treatment by cognition-behavior therapy with assistance of lactein 3 tablets thrice a day. Additionally

24 g of SJG was given three times a day to group A

and the same dosage of SJG and Smecta 15 g thrice a day was given to group B

while no additional treatment was given to the control group. The number of 5-HT+C was measured respectively before and two weeks after treatment by immunohistochemical method. The number of 5-HT+C decreased after treatment in all the three groups (P<0.05)

but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01

respectively)

while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05). SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type

and its effect is enhanced when used in combination with Smecta.

Abstract

To evaluate the effect of Shugan Jianpi Granule (舒肝健脾颗粒

24 g of SJG was given three times a day to group A

and the same dosage of SJG and Smecta 15 g thrice a day was given to group B

but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01

respectively)

while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05). SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type

and its effect is enhanced when used in combination with Smecta.

关键词

Shugan Jianpi GranuleIrritable Bowel Syndromeserotonin

Keywords

Shugan Jianpi GranuleIrritable Bowel Syndromeserotonin

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Seekers Centre for Integrative Medicine

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