Beneficial effect of HHI-I (活血化瘀注射液I号) on cerebral microcirculation, blood-brain barrier in rats and anti-hypoxic activity in mice

Lian-gen Zhao; Xian-zhong Wu; Xiao-xian Wu

doi:10.1007/s11655-009-0128-6

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Beneficial effect of HHI-I (活血化瘀注射液I号) on cerebral microcirculation, blood-brain barrier in rats and anti-hypoxic activity in mice

Updated：2021-08-27

- Beneficial effect of HHI-I (活血化瘀注射液I号) on cerebral microcirculation, blood-brain barrier in rats and anti-hypoxic activity in mice
- Chinese Journal of Integrative Medicine Vol. 15, Issue 2, Pages: 128-132(2009)
- Affiliations：
  
  Tianjin Institute of Acute Abdomen of Integrated Traditional Chinese and Western Medicine,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the Science Foundation of Tianjin Health Bureau (No. 03021)
- DOI：10.1007/s11655-009-0128-6
  CLC：
- Published：2009，
  
  Published Online：29 April 2009，
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Zhao, Lg., Wu, Xz. & Wu, Xx. Beneficial effect of HHI-I (活血化瘀注射液I号) on cerebral microcirculation, blood-brain barrier in rats and anti-hypoxic activity in mice., Chin. J. Integr. Med. 15, 128 (2009). https://doi.org/10.1007/s11655-009-0128-6

Lian-gen Zhao, Xian-zhong Wu, Xiao-xian Wu. Beneficial effect of HHI-I (活血化瘀注射液I号) on cerebral microcirculation, blood-brain barrier in rats and anti-hypoxic activity in mice. [J]. Chinese Journal of Integrative Medicine 15(2):128-132(2009)
Zhao, Lg., Wu, Xz. & Wu, Xx. Beneficial effect of HHI-I (活血化瘀注射液I号) on cerebral microcirculation, blood-brain barrier in rats and anti-hypoxic activity in mice., Chin. J. Integr. Med. 15, 128 (2009). https://doi.org/10.1007/s11655-009-0128-6 DOI：

Lian-gen Zhao, Xian-zhong Wu, Xiao-xian Wu. Beneficial effect of HHI-I (活血化瘀注射液I号) on cerebral microcirculation, blood-brain barrier in rats and anti-hypoxic activity in mice. [J]. Chinese Journal of Integrative Medicine 15(2):128-132(2009) DOI： 10.1007/s11655-009-0128-6.

摘要

To investigate the effect of HHI-I (活血化瘀注射液I号) on the cerebral microcirculation

the blood-brain barrier permeability in rats and anti-hypoxic activity in mice. (1) The blood microcirculation of the brain in rats was investigated by laser Doppler flowmetry with the probes laid on the cerebral pia mater or inserted into the brain parenchyma. (2) The protective action of HHI-I against the brain microcirculation disturbance induced by intravenous injection of high-molecular dextran (10%

9 mL/kg) was observed. (3) The protective effect of HHI-I against lethal hypoxia in mice was observed with a hypoxic chamber containing 5% oxygen. (4) The disruption of the blood-brain barrier (BBB) permeability in rats was caused by phenylephrine-induced hypertension

and the effect of intravenous injection of HHI-I on the BBB permeability was determined using Evans blue as the marker. HHI-I could increase the blood flow of the cerebral microcirculation in rats and possess some protective effects on the brain microcirculatory disturbance. Besides

HHI-I could decrease the brain edema occurring in the process of lethal hypoxia in mice. While increasing the blood flow of brain

HHI-I could lower the BBB permeability in rats. HHI-I has several beneficial effects on the cerebral microcirculation

blood-brain barrier in rats and anti-hypoxic activity in mice.

Abstract

To investigate the effect of HHI-I (活血化瘀注射液I号) on the cerebral microcirculation

HHI-I could decrease the brain edema occurring in the process of lethal hypoxia in mice. While increasing the blood flow of brain

HHI-I could lower the BBB permeability in rats. HHI-I has several beneficial effects on the cerebral microcirculation

blood-brain barrier in rats and anti-hypoxic activity in mice.

关键词

HHI-Icerebral microcirculationblood-brain barrier permeabilityhypoxia

Keywords

HHI-Icerebral microcirculationblood-brain barrier permeabilityhypoxia

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