To observe the clinical efficacy of Yinzhihuang Oral Liquid (YOL

茵栀黄口服液) to prevent the premature infantile jaundice. After excluded hemolytic

suffocation

infection

and the very low birth weight

242 cases of premature infants were randomly assigned to two groups

the treatment group and the control group. Both groups were taken conventional procedures

such as warmth

feeding

and blood glucose monitoring

and the treated group was administered YOL 5 mL each time

twice daily additionally

and the control group without any treatment. The percutaneous bilirubin and blood cells were observed every day. Compared the two groups

the jaundice indices were more significantly different at 24–48 h

48–72 h

and more than 72 h (P<0.05)

but not statistically different at 0–24 h (P>0.05). Hemoglobin

reticulocyte

platelets

and leucocyte were not significantly different between the two groups (P>0.05). YOL as an early intervention has positive significance to decrease the incidence of pathological jaundice in the premature infants

and no significant impact on the blood cells.