Supported by SHEN Bao-fan Academic Experience Inheritance Studio of Guangdong Provincial Hospital of Chinese Medicine,Conflict of Interest,The authors declare no conflict of interest of publication or others.,Author Contributions,Ling SS and Pan RH designed this study and wrote the draft. Chen HX conceived this study and revised the manuscript. Zhan LC helped with the operation training, including drugs distribution and assessment test. Li M was responsible for cases inclusion and randomization. Yang ZJ and Zhan LC helped with the data analysis. Yang HD and Ling SS registered and submitted this trial to ClinicalTrials.gov. All authors have read and approved the final version of this paper.