Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis

Ji Wei; Zhu Xuan-xuan; Tan Wen-feng; Lu Yan

doi:10.1007/BF02835742

Your Location：

Home >

Browse articles >

Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis

OriginalPaper | Updated：2021-08-27

- Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis
- Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis
- 中国结合医学杂志（英文版） 2005年11卷第1期页码：15-21
- Affiliations：
  
  Rheumatism Immunity Department of The First Hospital Affiliated to Nanjing University of Traditional Chinese Medicine
- Author bio：
- Funds：
  
  Supported by Project of Science and Technology Commission Foundation of Jiangsu Province in 1998
- DOI：10.1007/BF02835742
  中图分类号：
- 纸质出版日期：2005，
Scan for full text
Wei, J., Xuan-xuan, Z., Wen-feng, T. et al. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis., Chin. J. Integr. Med. 11, 15–21 (2005). https://doi.org/10.1007/BF02835742

Ji Wei, Zhu Xuan-xuan, Tan Wen-feng, et al. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis[J]. Chinese Journal of Integrative Medicine, 2005,11(1):15-21.
Wei, J., Xuan-xuan, Z., Wen-feng, T. et al. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis., Chin. J. Integr. Med. 11, 15–21 (2005). https://doi.org/10.1007/BF02835742 DOI：

Ji Wei, Zhu Xuan-xuan, Tan Wen-feng, et al. Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis[J]. Chinese Journal of Integrative Medicine, 2005,11(1):15-21. DOI： 10.1007/BF02835742.

摘要

Objective: To observe the clinical effect of Rebixiao granule (RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXGs therapeutic mechanism.Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group (n = 60) and control group (n = 30). The treated group was treated with RBXG

and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest

low purine diet

sufficient water drinking and urine alkalization

etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models.Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were won

insignificant difference (P>0.05)was shown between the two groups. However

the cure rate of the treated group was 26.7% while that of the control group was 10.0%

with significant difference (P<0.01) shown between them. The treated group had its blood uric acid lowered

which was significantly different (P<0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG

as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice.Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis

showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However

the compound recipe has better therapeutic effects

proving to be superior to single drugs.

Abstract

and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest

low purine diet

sufficient water drinking and urine alkalization

insignificant difference (P>0.05)was shown between the two groups. However

the cure rate of the treated group was 26.7% while that of the control group was 10.0%

with significant difference (P<0.01) shown between them. The treated group had its blood uric acid lowered

which was significantly different (P<0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG

the compound recipe has better therapeutic effects

proving to be superior to single drugs.

关键词

traditional Chinese medicine compoundrepeatedly attackingAcute Gouty Arthritistreatment

Keywords

traditional Chinese medicine compoundrepeatedly attackingAcute Gouty Arthritistreatment

references

State Administration of Traditional Chinese Medicine of P. R. China. The diagnosis and efficacy standard of traditional Chinese medicine standard of P. R. China. 1995: 87.

Wang JY. Internal medicine. 1st ed. Beijing: People’s Medical Publishing House, 2002: 996.

Shan ZY. The abstract and explain of 1999 WHO/ISH hypertension guideline. Liaoning J Pract Diabetol 2000;8(1): 5.

Hu MQ. New diagnosis and classification standard of diabetes. Natl Med J Chin 1999;84(2): 90.

Zhu XX, Ji W, Zhang XP, et al. Experimental research of acute gouty arthritis treatment by Heat-type arthralgia relieving granules taken with warm water. J Chin Med Standard 2002; 3 (1): 60.

State Administration of Traditional Chinese Medicine “Chinese Herbal Medicine” Compilation Commission, Chinese herbal medicine. 1st ed. Shanghai: Shanghai Scientific and Technical Publishers, 1998: 950.

Traditional Chinese Medicine Dictionary. 1st ed. Shanghai: Shanghai Scientific and Technical Publishers, 1997: 1565–1567.

Jin R, Zheng J, Liu ST. Preliminary research of mice hyperuicemia model. Acad J Chengdu Univ TCM 1999;22(1): 49.

Shi GY. Applying and evaluating of anti-inflammatory drugs. Chin J Rheumatol 2001;5: 342.

FULL TEXT LINK

More>

浏览量

391

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Current progress of Chinese medicinal treatment of endometriosis

Clinical observation on treatment of 32 patients with measles by Qingzhen Decoction (清疹汤)

Effect and prognostic analysis of treatment for acute myeloid leukemia using Chinese drugs combined with chemotherapy

Randomized and controlled clinical study of modified prescriptions of Simiao Pill (四妙丸) in the treatment of acute gouty arthritis

Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine