Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism

Guo Yan; Fan Li; Dong Liu-yi; Chen Zhi-wu

doi:10.1007/BF02835752

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Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism

OriginalPaper | Updated：2021-08-27

- Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism
- Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism
- 中国结合医学杂志（英文版） 2005年11卷第1期页码：57-59
- Affiliations：
  
  Department of Pharmacology, Anhui Medical University,Hefei
- Author bio：
- Funds：
  
  Supported by the Natural Science Fund of Anhui Province (No 99044433);Supported by the Nature and Science of Education Office of Anhui Province (No.2003 KJ 224)
- DOI：10.1007/BF02835752
  中图分类号：
- 纸质出版日期：2005，
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Yan, G., Li, F., Liu-yi, D. et al. Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism., Chin. J. Integr. Med. 11, 57–59 (2005). https://doi.org/10.1007/BF02835752

Guo Yan, Fan Li, Dong Liu-yi, et al. Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism[J]. Chinese Journal of Integrative Medicine, 2005,11(1):57-59.
Yan, G., Li, F., Liu-yi, D. et al. Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism., Chin. J. Integr. Med. 11, 57–59 (2005). https://doi.org/10.1007/BF02835752 DOI：

Guo Yan, Fan Li, Dong Liu-yi, et al. Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism[J]. Chinese Journal of Integrative Medicine, 2005,11(1):57-59. DOI： 10.1007/BF02835752.

摘要

Objective: To study the effects of total flavone of Abelmoschl Manihot L. Medic (TFA) on the function of platelets and to explore its mechanism.Methods: Rat models of artery-veins bypassing thrombus formation were used. The platelets of rabbits were collected. Platelet aggregation was induced by collagen and intracellular calcium ion concentration ([Ca2+]i) was assayed by Fura-2 method.Results: TFA (25

100 mg/kg) significantly and dose-dependently reduced the weight of thrombus. TFA (0.025

0.05

0.1 mg/ ml) possessed dose-dependant inhibitory effects on rabbits’ platelet aggregation induced by collagen. TFA significantly reduced the resting and CaCl2-induced increase of free intracellular calcium concentration ([Ca2+]i) in rabbit plateletin vitro.Conclusion: TFA has an antiplatelet effect via the inhibition on the influx of Ca2+.

Abstract

100 mg/kg) significantly and dose-dependently reduced the weight of thrombus. TFA (0.025

0.05

关键词

total flavone of Abelmoschl Manihot L. MedicthrombosisPlatelet AggregationcalciumFura-2

Keywords

total flavone of Abelmoschl Manihot L. MedicthrombosisPlatelet AggregationcalciumFura-2

references

Chen ZW, Ma CG. Effects of hyperin on free intracellular calcium in dissociated neonatal rat brain cells. Acta Pharm Sin 1999; 20(1): 27–30.

Xiao D, Gu ZL, Bai JP, et al. Effects of quercetin on aggregation and intracellular free calcium of platelets. Acta Pharm Sin 1995;16(3): 223–226.

Guo Y, Chen ZW. Protective effect of total flavone of Abelmoschl Manihot L. Medic against cerebral ischemia-reperfusion injury. Chin Pharmacol Bull 2002; 18(6): 692–695.

Chen JS, Liang LG. A new quantitative thrombosis model in rats. Chin Pharmacol Bull 1996; 12: 473–474.

Born GVR. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962; 194: 927–929.

Dildy JE, Leslie SW. Ethanol inhibits NMPA-induced increase in free intracellular Ca in dissociated brain cells. Brain Res 1989;499: 383–386.

Ardlie NG. Calcium ions, drug action, and platelet function. Pharmacol Ther 1982;18: 249–270.

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