Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura

Zhou Yong-ming; Huang Zhen-qiao; Hu Ming-hui; Zhou Shao-hong; Huang Tao; Xu Yi; Lu Jia-hui; Gan Xiao-fang; Zhu Wen-wei

doi:10.1007/BF02835753

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Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura

OriginalPaper | Updated：2021-08-27

- Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura
- Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura
- 中国结合医学杂志（英文版） 2005年11卷第1期页码：60-64
- Affiliations：
  
  Yueyang Hospital of Integrated Traditional and Western Medicine, Shanghai University of TCM,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02835753
  中图分类号：
- 纸质出版日期：2005，
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Yong-ming, Z., Zhen-qiao, H., Ming-hui, H. et al. Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura., Chin. J. Integr. Med. 11, 60–64 (2005). https://doi.org/10.1007/BF02835753

Zhou Yong-ming, Huang Zhen-qiao, Hu Ming-hui, et al. Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura[J]. Chinese Journal of Integrative Medicine, 2005,11(1):60-64.
Yong-ming, Z., Zhen-qiao, H., Ming-hui, H. et al. Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura., Chin. J. Integr. Med. 11, 60–64 (2005). https://doi.org/10.1007/BF02835753 DOI：

Zhou Yong-ming, Huang Zhen-qiao, Hu Ming-hui, et al. Clinical study on the effect of Shengxueling on idiopathic thrombocytopenic purpura[J]. Chinese Journal of Integrative Medicine, 2005,11(1):60-64. DOI： 10.1007/BF02835753.

摘要

Objective: To observe the clinical effect of Shengxueling (SXL) on idiopathic thrombocytopenic purpura (ITP)

and study the possible mechanism.Methods: Eighty-six cases of ITP were randomly divided into two groups. The SXL group

56 patients treated with SXL

a traditinal Chinese medicine and 30 patients administered with prednisone were taken as control. Each group took drugs for 3 months and was under follow-up observation.Results: In the SXL group

the total effective rate was 85. 71%

similar to prednisone 83. 33%(P>0. 05) for 3 months

but the total effective rate of SXL (91.07%) were obviously better than that of the control group (53. 33%) (P<0.01) for 6 months and had no obvious adverse reaction. The patients bleeding was alleviated or stopped

the general condition was improved. At the same time

blood platelet count (PLT) was increased

platelet associated immunoglobulin (PAIg) and interleukin-4 (IL-4) were markedly dropped

the level of natural killers cells activity (NKa) increased

the rate of T lymphocyte subsets gradually returned to normal level. Megakaryocyte tended to maturation on bone marrow smear after treatment. All differences above were statistically significant.Conclusion: SXL is an effective and safe medicine for ITP. Its mechanism could regulate cytoimmune

inhibit platelet antibody to reduce the destruction of platelet

increase the number of platelet

promote the division and maturation of megakaryocyte

facilitate the production and release of platelet

lower the fragility of capillary

prevent and cure hemorrhagic tendency.

Abstract

Objective: To observe the clinical effect of Shengxueling (SXL) on idiopathic thrombocytopenic purpura (ITP)

and study the possible mechanism.Methods: Eighty-six cases of ITP were randomly divided into two groups. The SXL group

56 patients treated with SXL

a traditinal Chinese medicine and 30 patients administered with prednisone were taken as control. Each group took drugs for 3 months and was under follow-up observation.Results: In the SXL group

the total effective rate was 85. 71%

similar to prednisone 83. 33%(P>0. 05) for 3 months

the general condition was improved. At the same time

blood platelet count (PLT) was increased

platelet associated immunoglobulin (PAIg) and interleukin-4 (IL-4) were markedly dropped

the level of natural killers cells activity (NKa) increased

inhibit platelet antibody to reduce the destruction of platelet

increase the number of platelet

promote the division and maturation of megakaryocyte

facilitate the production and release of platelet

lower the fragility of capillary

prevent and cure hemorrhagic tendency.

关键词

ShengxuelingIdiopathic Thrombocytopenic PurpuraTraditional Chinese Medicine Therapy

Keywords

ShengxuelingIdiopathic Thrombocytopenic PurpuraTraditional Chinese Medicine Therapy

references

Zhang ZN, Shen D. Hematology diagnosis and therapeutic effect criteria. 2nd ed. Beijing: Science Press, 1999: 279–282.

Chen BY, Ma JY, Huang QT, et al. Modification of simple nature killer test — LDH release. J Shanghai Immunol 1989;(4): 201, 218–219.

Zhang MH, Song SQ, Zhang D, et al. Comparison between lymphocyte leukemia immunity type by immunity enzyme staining method. Chin J Hematol 1990; (11): 40–41.

The National Association of TCM, Internal Medicine Society. The criteria of bleeding grading in ITP. J Beijing Coll TCM 1984;7(4): 25–27.

Vignaux F, Golstein P. Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: a regulatory pathway. Eur J Immunol 1994;24: 923–927.

McFarland J. Pathophysiology of platelet destruction in immune (idiopathic) thrombocytopenic purpura. Blood Rev 2002;16: 1–2.

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