Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus

Cheng Shi-ping; Liu Jia-lin; Yuan Jing

doi:10.1007/BF02835754

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Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus

OriginalPaper | Updated：2021-08-27

- Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus
- Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus
- 中国结合医学杂志（英文版） 2005年11卷第1期页码：65-68
- Affiliations：
  
  Nephrology Department, People’s Hospital of Guizhou Province,Guiyang
- Author bio：
- Funds：
- DOI：10.1007/BF02835754
  中图分类号：
- 纸质出版日期：2005，
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Shi-ping, C., Jia-lin, L. & Jing, Y. Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus., Chin. J. Integr. Med. 11, 65–68 (2005). https://doi.org/10.1007/BF02835754

Cheng Shi-ping, Liu Jia-lin, Yuan Jing. Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus[J]. Chinese Journal of Integrative Medicine, 2005,11(1):65-68.
Shi-ping, C., Jia-lin, L. & Jing, Y. Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus., Chin. J. Integr. Med. 11, 65–68 (2005). https://doi.org/10.1007/BF02835754 DOI：

Cheng Shi-ping, Liu Jia-lin, Yuan Jing. Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus[J]. Chinese Journal of Integrative Medicine, 2005,11(1):65-68. DOI： 10.1007/BF02835754.

摘要

Objective: to explore the mechanism of leeching in treating systemic lupus erythematosus (SLE).Methods: Forty-four patients with SLE were randomly divided into conventional corticosteroid treated group (control group

n = 20) and conventional treatment group with leeching intervention added (leeching group

n = 24). Before and after treatment the concentration of plasma endothelin (ET) and soluble interleukin-2 receptor (sIL-2R) were determined.Results: Before treatment the level of plasma ET and sIL-2R in the SLE patients were all higher than those in the normal healthy group

(P<0.01). But after treatment the level of these in both groups were significantly improved than those of before treatment (P<0.05)

and comparison between these two treated groups showed that the difference between them was significant (P<0.05).Conclusion: Leeching added to conventional treatment of SLE could be more effective in improving the level of plasma ET and sIL-2R

and ameliorating the impairment of renal tissues.

Abstract

n = 20) and conventional treatment group with leeching intervention added (leeching group

(P<0.01). But after treatment the level of these in both groups were significantly improved than those of before treatment (P<0.05)

and ameliorating the impairment of renal tissues.

关键词

systemic lupus erythematosusendothelinsoluble interleukin-2 receptorleech

Keywords

systemic lupus erythematosusendothelinsoluble interleukin-2 receptorleech

references

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Perico N, Remazzi G. The possible role of endothelin in the process of progressive renal deterioration in experimental and human glomerulopathies. Semin Nephrol 1993;13: 37–45.

Chen JK, Zou WZ, You JF. Study on glomerular masangial intracellular Aosuo receptor. Chin J Nephrol 1997; 3(1): 51–53.

Yu XQ, Li HQ, Ye RG, et al. Change of urinary endothelin of chronic nephropathies and its clinical significance. Chin J Nephr 1995;11(2): 91–92.

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Xie YH, Wang SW, Guo Q. Experimental study on the anti-inflammatory effect of Chinese drug leech. Acad J 4th Mili Med Univ 1996;17(6): 431–433.

Chen XM, Fu B, Ye YZ, et al. Up-regulated expression on intercellular adhesive molecule-1 of the thrombin mediated glomerular mesangial cell and the blockage of hirudin. Chin J Nephrol 1998;14(4): 211–214.

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