A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis

Yu Wen-ya; Shen Shu-wen; Yang Zhi-hong

doi:10.1007/BF02835785

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A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis

OriginalPaper | Updated：2021-08-27

- A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis
- A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis
- 中国结合医学杂志（英文版） 2005年11卷第4期页码：255-259
- Affiliations：
  
  1. Shaanxi College of Traditional Chinese Medicine,Shaanxi
  2. Affiliated Hospital of Shaanxi College of Chinese Medicine,China
- Author bio：
- Funds：
  
  Supported by grants from the Bureau of Education of Shaanxi Province(No. 05JK171)
- DOI：10.1007/BF02835785
  中图分类号：
- 纸质出版日期：2005，
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Wen-ya, Y., Shu-wen, S. & Zhi-hong, Y. A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis., Chin. J. Integr. Med. 11, 255–259 (2005). https://doi.org/10.1007/BF02835785

Yu Wen-ya, Shen Shu-wen, Yang Zhi-hong. A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis[J]. Chinese Journal of Integrative Medicine, 2005,11(4):255-259.
Wen-ya, Y., Shu-wen, S. & Zhi-hong, Y. A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis., Chin. J. Integr. Med. 11, 255–259 (2005). https://doi.org/10.1007/BF02835785 DOI：

Yu Wen-ya, Shen Shu-wen, Yang Zhi-hong. A clinical study of Suogudan Granule in the treatment of rheumatoid arthritis[J]. Chinese Journal of Integrative Medicine, 2005,11(4):255-259. DOI： 10.1007/BF02835785.

摘要

Objective: To study the clinical efficacy of Suogudan Granule (SGDG) in the treatment of rheumatoid arthritis (RA).Methods: Ninety patients with RA were randomly divided into the treated group and the control group. The treated group was administered orally with SGDG 6 g each time

thrice a day

while the control group with the combined therapy of Fenbid Capsules 0.3 g each time

twice a day and Tripterygium tablet 20 mg each time

thrice a day. The treatment course for both groups was 6 weeks. The changes of clinical symptoms and signs

and laboratory indices such as erythrocyte sedimentation rate (ESR)

rheumatoid factor (RF)

antistreptolysin O (ASO)

routine examination of blood and urine

liver and kidney function

etc. before and after treatment were observed.Results: (1) The total effective rate in the treated group (88. 0%) was obviously higher than that in the control group (67. 5%) with significant difference (P<0.05). (2) The improvement in arthralgia

joint swelling

time of morning stiffness

15-meter walking

analgesia initiation and persistence in the treated group was better than that in the control group (P<0.05

P<0.01)

but there was no obvious difference in improvement of joint tenderness

range of joint motion

grip strength

and initiating detumescence time (P>0.05). (3) The improvement in ESR and RF in the treated group was better than that in the control group with significant difference (P<0.05). The negative conversion rate of ASO in the treated group was also higher than that in the control group (P<0. 01). (4) No evident abnormality in blood

urine

liver or kidney function was found in either group.Conclusion: SGDG is effective and safe for the treatment of RA.

Abstract

thrice a day

while the control group with the combined therapy of Fenbid Capsules 0.3 g each time

twice a day and Tripterygium tablet 20 mg each time

thrice a day. The treatment course for both groups was 6 weeks. The changes of clinical symptoms and signs

and laboratory indices such as erythrocyte sedimentation rate (ESR)

rheumatoid factor (RF)

antistreptolysin O (ASO)

routine examination of blood and urine

liver and kidney function

joint swelling

time of morning stiffness

15-meter walking

analgesia initiation and persistence in the treated group was better than that in the control group (P<0.05

P<0.01)

but there was no obvious difference in improvement of joint tenderness

range of joint motion

grip strength

urine

liver or kidney function was found in either group.Conclusion: SGDG is effective and safe for the treatment of RA.

关键词

rheumatoid arthritisSuogudan GranuleTraditional Chinese Medicine Therapy

Keywords

rheumatoid arthritisSuogudan GranuleTraditional Chinese Medicine Therapy

references

Jiang M, Zhu LP, Lin XY. Rheumatology (Vol 1). Bei-jing: Science Press, 1995: 815–819.

Shen SW, Wang PL, Yu WY. Experimental study of long-term toxicity of Suogudan granule. Modern Tradit Chin Med 2005;25(l): 47–49.

Wang ZM, Guo XZ, Bai RR. Treatment of rheumatoid arthritis by TCM and Western medicine. Tianjin: Tian-jin Science and Technology Press, 1989: 553.

Issued by Ministry of Health People’s Republic of Chi-na. Guiding principles for clinical study of new Chinese medicines, Beijing: China Medico-Pharmaceutical Sci-ences and Technology Publishing House, 1993: 210–214.

Shaanxi Institute of TCM, Chinese Academy of Medical Sciences. Shaanxi Chinese Materia Medica (Vol 1). Xi’ an: Shaanxi People’s Publishing House, 1961: 246–247.

Li SQ. Natural materia medica of Qinling and Bashan mountains. Xi’an: Shaanxi Science and Technology Press, 1987: 251–252.

Shen SW, Yu WY, Wang PL. Therapeutic efficacy of Suogudan on rats with adjuvant monoarthritis and its in-fluences on ESR, CRP, RF, IgA, IgG and IgM. Chin J Clin Tradit West Med 2004;4(1): 47–49.

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