Study on effect of Zhixinkang Capsule in treating unstable effort angina and hyperlipidemia and its function in vascular endothelium protection

Zhang Wen-gao; Yan Ting-xiang; Gao Fu-jun; Meng Xian-zhong; Liu Jian-ping; Yin Ge-ping; Liu Li-li; Luo Nan-ping; Shi Bing-e; Ma Xue-sheng

doi:10.1007/BF02836349

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Study on effect of Zhixinkang Capsule in treating unstable effort angina and hyperlipidemia and its function in vascular endothelium protection

OriginalPaper | Updated：2021-08-27

- Study on effect of Zhixinkang Capsule in treating unstable effort angina and hyperlipidemia and its function in vascular endothelium protection
- Study on effect of Zhixinkang Capsule in treating unstable effort angina and hyperlipidemia and its function in vascular endothelium protection
- 中国结合医学杂志（英文版） 2003年9卷第1期页码：25-30
- Affiliations：
  
  1. Shandong University of TCM,Jinan
  2. Jinan Mengs Institute of Biological Technology,China
  3. Jinan Military Regional General Hospital,China
  4. The First People’s Hospital of Jinan,China
- Author bio：
- Funds：
  
  study was funded by Natural Science Foundation of Shandong Province (No. Y97C22058)
- DOI：10.1007/BF02836349
  中图分类号：
- 纸质出版日期：2003，
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Wen-gao, Z., Ting-xiang, Y., Fu-jun, G. et al. Study on effect of Zhixinkang Capsule in treating unstable effort angina and hyperlipidemia and its function in vascular endothelium protection., Chin. J. Integr. Med. 9, 25–30 (2003). https://doi.org/10.1007/BF02836349

Zhang Wen-gao, Yan Ting-xiang, Gao Fu-jun, et al. Study on effect of Zhixinkang Capsule in treating unstable effort angina and hyperlipidemia and its function in vascular endothelium protection[J]. Chinese Journal of Integrative Medicine, 2003,9(1):25-30.
Wen-gao, Z., Ting-xiang, Y., Fu-jun, G. et al. Study on effect of Zhixinkang Capsule in treating unstable effort angina and hyperlipidemia and its function in vascular endothelium protection., Chin. J. Integr. Med. 9, 25–30 (2003). https://doi.org/10.1007/BF02836349 DOI：

Zhang Wen-gao, Yan Ting-xiang, Gao Fu-jun, et al. Study on effect of Zhixinkang Capsule in treating unstable effort angina and hyperlipidemia and its function in vascular endothelium protection[J]. Chinese Journal of Integrative Medicine, 2003,9(1):25-30. DOI： 10.1007/BF02836349.

摘要

Objective:To observe the clinical effect and protection of vascular endothelium of Zhixinkang Capsule (ZXKC) in middle-aged and old people with unstable effort angina and hyperlipidemia.Methods: Sixty-five patients with unstable effort angina were randomly divided into ZXKC group (34 cases) and control group (31 cases). Conventional western medical therapy was given to both groups

with ZXKC group receiving additional ZXKC treatment. Data of 20 healthy persons were taken as normal group. Forty-eight patients with hyperlipidemia were divided into ZXKC group treated with ZXKC (31 cases) and control group treated with Yixintong (17 cases). The changes of clinical symptoms and laboratory indexes in all the patients were observed before and after treatment.Results: In patients with unstable effort angina

the efficacy of treatment of ZXKC

the withdrawal rate of nitroglycerin

the relieving of symptoms

the improvement of the electrocardiogram

the counts of circulating endothelial cells

the content of platelet P-selectin

the content of plasma endothelin (ET)

the activity of Superoxide dismutase (SOD) and the activity of malonyldialdehyde (MDA) were all better than those in the control group. In patients with hyperlipidemia

there was no significant difference in lipids reduction between ZXKC group and the control group. In both groups

the total cholesterol (TC)

triglyceride (TG)

low density lipoprotein-cholesterol (LDL-C)

lipoprotein(a) [Lp(a)]

oxidized low density lipoprotein

MDA

arteriosclerotic index (AI) all lowered obviously

while the SOD

HDL-C and calcitonin gene-related peptide (CGRP) were all elevated markedly. In the ZXKC group

the nitric oxide (NO) increased significantly whereas the ET/CGRP and ET/NO decreased markedly. The total effective rate in symptom relieving

the markedly effective rate

the reduction of TC

ET and ET/CGRP

and the elevation of SOD in ZXKC group were all superior to those in the control group.Conclusion: ZXKC could effectively resist myocardial ischemia

relieve angina

reduce blood lipids

protect vascular endothelial cells

inhibit the activation of platelets

and resist lipid peroxidation.

Abstract

the efficacy of treatment of ZXKC

the withdrawal rate of nitroglycerin

the relieving of symptoms

the improvement of the electrocardiogram

the counts of circulating endothelial cells

the content of platelet P-selectin

the content of plasma endothelin (ET)

the activity of Superoxide dismutase (SOD) and the activity of malonyldialdehyde (MDA) were all better than those in the control group. In patients with hyperlipidemia

there was no significant difference in lipids reduction between ZXKC group and the control group. In both groups

the total cholesterol (TC)

triglyceride (TG)

low density lipoprotein-cholesterol (LDL-C)

lipoprotein(a) [Lp(a)]

oxidized low density lipoprotein

MDA

arteriosclerotic index (AI) all lowered obviously

while the SOD

HDL-C and calcitonin gene-related peptide (CGRP) were all elevated markedly. In the ZXKC group

the nitric oxide (NO) increased significantly whereas the ET/CGRP and ET/NO decreased markedly. The total effective rate in symptom relieving

the markedly effective rate

the reduction of TC

ET and ET/CGRP

and the elevation of SOD in ZXKC group were all superior to those in the control group.Conclusion: ZXKC could effectively resist myocardial ischemia

relieve angina

reduce blood lipids

protect vascular endothelial cells

inhibit the activation of platelets

and resist lipid peroxidation.

关键词

unstable effort anginahyperlipidemiaZhixinkang capsuleprotection of vascular endotheliumtherapy of traditional Chinese medicine

Keywords

unstable effort anginahyperlipidemiaZhixinkang capsuleprotection of vascular endotheliumtherapy of traditional Chinese medicine

references

Nomenclature and Diagnostic Standard for Ischemic Heart Disease. Combined Special Group on Nomenclature Standardization of the International Cardiology Association and WHO. J Chin Cardiovas Dis 1981;9(1): 75.

Guiding Principles of Clinical Research on New Chinese Drugs (Part II). Ministry of Health, PRC 1995: 171.

SU CL, SHENG SG. Modern Cardiology of TCM. Beijing: Beijing Science and Technology Press, 1997: 529–534.

CHEN KJ, LIAO JZ, XIAO ZX. Research on Cardio-cerebro-vascular Diseases. Shanghai: Shanghai Science and Technology Press, 1988: 318–319.

Guiding Principles in Clinical Research on New Chinese Drugs in Treating Senile Diseases. Administration of Pharmaceutic Affair, Ministry of Health, PRC. J Chin Med Pharm 1989; 4(3): 72.

YANG LX, ZHANG CD. Correlative research on circulating endothelial cells and plasma endothelin in patients with coronary heart disease. J Clin Cardiovasc Dis 1995; 11 (5): 273.

Rand ML, Sangrar W, Hancock MA, et al. Apolipoprotein(a) enhances platelet responses to the thrombin receptor-activating peptide SFLLRN. Arterioscler Thromb Vasc Biol1998;18 (9): 1393–1399.

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