Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension

Wang Zi-fen; Shi Shao-lan; Song Hai-xiang

doi:10.1007/BF02836352

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Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension

OriginalPaper | Updated：2021-08-27

- Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension
- Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension
- 中国结合医学杂志（英文版） 2003年9卷第1期页码：35-38
- Affiliations：
  
  Linyi Municipal TCM Hospital, Shangdong
- Author bio：
- Funds：
- DOI：10.1007/BF02836352
  中图分类号：
- 纸质出版日期：2003，
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Zi-fen, W., Shao-lan, S. & Hai-xiang, S. Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension., Chin. J. Integr. Med. 9, 35–38 (2003). https://doi.org/10.1007/BF02836352

Wang Zi-fen, Shi Shao-lan, Song Hai-xiang. Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension[J]. Chinese Journal of Integrative Medicine, 2003,9(1):35-38.
Zi-fen, W., Shao-lan, S. & Hai-xiang, S. Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension., Chin. J. Integr. Med. 9, 35–38 (2003). https://doi.org/10.1007/BF02836352 DOI：

Wang Zi-fen, Shi Shao-lan, Song Hai-xiang. Effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension[J]. Chinese Journal of Integrative Medicine, 2003,9(1):35-38. DOI： 10.1007/BF02836352.

摘要

Objective:To investigate the effect of prepared rhubarb on insulin resistance in patients with pregnancy induced hypertension (PIH) and its mechanism.Methods: All the 92 patients accepted 75 g oral glucose tolerance test (OGTT) and insulin release test before and after treatment. These patients were divided into two groups (treated group and control group). Prepared rhubarb and nifedipine were given to the treated group

while nifedipine was given to the control group alone. Circulating endothelial cell (CEC)

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) were measured and glucose area under curve (GAUC)

insulin area under curve (IAUC)

insulin sensitivity index (ISI) were calculated. And 30 normal pregnant women were selected as the healthy group.Results: CEC

TNF-α

IL-6

GAUC and IAUC of PIH patients were significantly higher than those of the normal healthy group; while ISI of PIH patients was significantly lower than that of the healthy group. ISI was significantly negatively correlated to CEC

TNF-α and IL-6. After treatment

CEC

TNF-α

IL-6

GAUC decreased and ISI increased significantly in the treated group; while in the control group

all above-mentioned parameters showed no change.Conclusion: Prepared rhubarb can improve insulin resistance of PIH by reducing vascular endothelial cell’s damage.

Abstract

while nifedipine was given to the control group alone. Circulating endothelial cell (CEC)

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) were measured and glucose area under curve (GAUC)

insulin area under curve (IAUC)

insulin sensitivity index (ISI) were calculated. And 30 normal pregnant women were selected as the healthy group.Results: CEC

TNF-α

IL-6

TNF-α and IL-6. After treatment

CEC

TNF-α

IL-6

GAUC decreased and ISI increased significantly in the treated group; while in the control group

all above-mentioned parameters showed no change.Conclusion: Prepared rhubarb can improve insulin resistance of PIH by reducing vascular endothelial cell’s damage.

关键词

pregnancy complicationcardiovascularhypertensionprepared rhubarbinsulin resistance

Keywords

pregnancy complicationcardiovascularhypertensionprepared rhubarbinsulin resistance

references

Solomon CG, Graves SW, Greene MF, et al. Glucose intolerance as a predictor of hypertension in pregnancy. Hypertension 1994; 23: 717–721.

XU XM, QIAO M, WANG ML. Relationship between insulin resistance and PIH. Chin J Obstetrics Gynecology 2000;35 (10): 597–599.

ZHANG ZJ, CHENG WW, YANG YM, et al. Study on low-dose of prepared rhubarb in preventing pregnancy induced hypertension. Chin J Obstetrics Gynecology 1994;29 (7): 463–464.

WANG ZF, SONG HX. Clinical observation on therapeutic effect of prepared rhubarb in treating pregnancy induced hypertension. Chin J Integr Med (Chin) 1999;19 (12): 725–727.

WANG ZF, SONG HX, SHI SL, et al. Clinical significance of change of interleukin-6 level in pregnancy induced hypertension. Chin J Obstetrics Gynecology 1999; 34 (4): 220–221.

WANG ZF, SONG HX, SHI SL, et al. Relationship between damage of vascular endothelial cell and interleukin-6 of pregnancy induced hypertension. Chin J Obstetrics Gynecology 2000;35 (5): 301–302.

LI KB, WANG LY, TONG XH, et al. Study on tumor necrosis factor and pathogenesis of pregnancy induced hypertension. Chin J Obstetrics Gynecology 1999; 34 (6): 339–341.

DONG JX, SHI YB, HAN HQ, et al. Study on the changes of interleukin-6 and tumor necrosis factor α and T-cell subsets of type-2 diabetes mellitus. Chin J Endocrinol Metab 1999;15 (5): 370–371.

Zhonghua Bencao Association. Zhonghua Bencao. 1st edition. Shanghai: Shanghai Science and Technology Publishing House, 1998: 355–371.

DAI CS, LIU ZH, CHEN HP, et al. Experimental study on rhein treating on rat diabetes mellitus induced by STZ. Chin J Nephrology Dialysis Transplantation 1999;8 (5): 413–419.

Castiglione S, Fanciuli M, Bruno T, et al. Rhein inhibits glucose uptake in Ehrlich ascites tumor cells by alteration of membrane -associated functions. Anti-cancer Drugs 1993;4: 407–414.

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