Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats

Qiu Hong; Jin Guo-qin; Zhao Wei-kang; Zhang Xue-li

doi:10.1007/BF02836355

Your Location：

Home >

Browse articles >

Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats

OriginalPaper | Updated：2021-08-27

- Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats
- Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats
- 中国结合医学杂志（英文版） 2003年9卷第1期页码：44-48
- Affiliations：
  
  1. Institute of Basic Medicine, Shanghai University of TCM,Shanghai
  2. The Research Institute of Gerontology of Shanghai TCM,China
- Author bio：
- Funds：
  
  This program was supported by National Natural Science Foundation of China (No. 39830450)
- DOI：10.1007/BF02836355
  中图分类号：
- 纸质出版日期：2003，
Scan for full text
Hong, Q., Guo-qin, J., Wei-kang, Z. et al. Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats., Chin. J. Integr. Med. 9, 44–48 (2003). https://doi.org/10.1007/BF02836355

Qiu Hong, Jin Guo-qin, Zhao Wei-kang, et al. Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats[J]. Chinese Journal of Integrative Medicine, 2003,9(1):44-48.
Hong, Q., Guo-qin, J., Wei-kang, Z. et al. Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats., Chin. J. Integr. Med. 9, 44–48 (2003). https://doi.org/10.1007/BF02836355 DOI：

Qiu Hong, Jin Guo-qin, Zhao Wei-kang, et al. Effect of Tiaoxin Recipe on spatial memory and energy metabolism of oxidation injured Alzheimers disease rats[J]. Chinese Journal of Integrative Medicine, 2003,9(1):44-48. DOI： 10.1007/BF02836355.

摘要

Objective: To observe the effect of Tiaoxin Recipe (TXR) on the spatial memory

brain mitochondrial energy metabolism of oxidation injured Alzheimer’s disease (AD) rats

and to explore the mechanism of TXR in treating AD.Methods: Eighty-eight SD rats were randomly divided into five groups (normal group

operative group

“AD” model group

TXR group and Aricept group). An oxygen free radical generation system (dihydroxy fumaric acid-trichloroferric-adenosine diphosphate

DHF-FeCl3-ADP) was used to create oxidation injured rat models mimic to AD; spatial learning and memory impairment (Morris water maze method)

the activity of Succinate-oxidase

NADH-oxidase

CytC-oxidase (Clark oxygen electrode method) and the expression of cytochrome oxidase (CO) II mRNA (in situ hybridization method) were observed.Results: Compared with the normal group

the spatial memory

activity of CytCoxidase and COII mRNA expression of oxidation injured “AD” rats were obviously decreased; TXR

however

could improve these functions in “AD” rat models obviously.Conclusion: The mechanism of the action of TXR in treating AD was partly related to its effect on anti-oxidation which could improve brain mitochondrial energy metabolism.

Abstract

Objective: To observe the effect of Tiaoxin Recipe (TXR) on the spatial memory

brain mitochondrial energy metabolism of oxidation injured Alzheimer’s disease (AD) rats

and to explore the mechanism of TXR in treating AD.Methods: Eighty-eight SD rats were randomly divided into five groups (normal group

operative group

“AD” model group

TXR group and Aricept group). An oxygen free radical generation system (dihydroxy fumaric acid-trichloroferric-adenosine diphosphate

DHF-FeCl3-ADP) was used to create oxidation injured rat models mimic to AD; spatial learning and memory impairment (Morris water maze method)

the activity of Succinate-oxidase

NADH-oxidase

CytC-oxidase (Clark oxygen electrode method) and the expression of cytochrome oxidase (CO) II mRNA (in situ hybridization method) were observed.Results: Compared with the normal group

the spatial memory

activity of CytCoxidase and COII mRNA expression of oxidation injured “AD” rats were obviously decreased; TXR

however

关键词

Tiaoxin Recipeoxidation injuryspatial memoryenergy metabolism

Keywords

Tiaoxin Recipeoxidation injuryspatial memoryenergy metabolism

references

LI YM, ZHANG CY, LIN SM. Theoretical exploration on Xin-benefiting and Shen-tonifying method in treating AD. J Gansu College TCM 2000;17(2): 1–3.

LIN SM. Clinical research on the effect of TXR on Alzheimer’s disease. J Shanghai Univ TCM 1997; 11(1): 44.

Morris RJ. Developments of a water-maze procedure for studying spatial learning in the rats. Neurosci Methods 1984;11: 47–60.

Zini R, Morin C, Bertelli A, et al. Effect of resveratrol on the rat brain respiratory chain. Drugs Exptl Clin Res 1999;XXV(2/3): 87–97.

Heinz S, John JL, Matthias H, et al. Liposome-mitochondrial inner membrane fusion. J Biochem 1980; 255(8): 3748–3756.

Nancy A, Simonian NA, Hyman BT, et al. Functional alterations in Alzheimer’s disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation. J Neuropathol Exp Neurol 1994; 53 (5): 508–512.

Meier Ruge W, Iwangoff P, Bertoni Freddari C, et al. What is primary and what is secondary for amyloid deposition in Alzheimer’s disease. Ann NY Acad Sci 1994; 719: 23–27.

Mecocci P, MacGarvey U, Kaufman AE, et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 1993; 34: 609–616.

FULL TEXT LINK

More>

浏览量

363

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Roles and mechanisms of ginseng in protecting heart

Effects of Radix aconiti lateralis preparata and Rhizoma zingiberis on energy metabolism and expression of the genes related to metabolism in rats

Good regulation of acupuncture in simple obesity patients with stomach-intestine excessive heat type

Combination of total Astragalus extract and total Panax notoginseng saponins strengthened the protective effects on brain damage through improving energy metabolism and inhibiting apoptosis after cerebral ischemia-reperfusion in mice

Effects of electroacupuncture of different intensities on energy metabolism of mitochondria of brain cells in rats with cerebral ischemia-reperfusion injury