Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model

Yang Zhen-jiang; Zhao Xia; Zou Ying-zhen; Feng Yu-li; Dai Ling

doi:10.1007/BF02836385

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Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model

OriginalPaper | Updated：2021-08-27

- Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model
- Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model
- 中国结合医学杂志（英文版） 2004年10卷第2期页码：127-130
- Affiliations：
  
  Shenzhen Municipal TCM Hospital,Guangdong
- Author bio：
- Funds：
  
  This study was supported by Guangdong Provincial TCM Administration Bureau (No. 98107)
- DOI：10.1007/BF02836385
  中图分类号：
- 纸质出版日期：2004，
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Zhen-jiang, Y., Xia, Z., Ying-zhen, Z. et al. Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model., Chin. J. Integr. Med. 10, 127–130 (2004). https://doi.org/10.1007/BF02836385

Yang Zhen-jiang, Zhao Xia, Zou Ying-zhen, et al. Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model[J]. Chinese Journal of Integrative Medicine, 2004,10(2):127-130.
Zhen-jiang, Y., Xia, Z., Ying-zhen, Z. et al. Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model., Chin. J. Integr. Med. 10, 127–130 (2004). https://doi.org/10.1007/BF02836385 DOI：

Yang Zhen-jiang, Zhao Xia, Zou Ying-zhen, et al. Exploration on effect and mechanism of Suiqing Pill on tumor angiogenesis in nude mouse b16 melanoma model[J]. Chinese Journal of Integrative Medicine, 2004,10(2):127-130. DOI： 10.1007/BF02836385.

摘要

Objective: To study the effect of Suiqing Pill (SQP)

a TCM compound drug that can activate blood circulation and get rid of blood stasis

on angiogenesis in tumor and its possible mechanism.Method: BALB/c nude mice were inoculated with melanoma cell line B16 at right armpit subcutaneously to establish cancer spontaneous metastasis model. Levels of microvessel density (MVD)

vascular endothelial growth factor (VEGF) and protein expression of matrix metalloproteinase-2 (MMP-2) in tumor tissues were observed and compared.Results: Strong expression of anti-Factor VIII (FVIII) related antigen and plentiful tumor angiogenesis were seen in model control animals

while in the high-dose and low-dose SQP treated model mice

MVD was inhibited by 33.5% and 22.6% respectively (P<0.01

P<0.05). The strong positive protein expression of VEGF and MMP-2 in model control also reduced in the SQP treated groups.Conclusion: SQP could inhibit tumor angiogenesis

protein expression of VEGF and MMP-2 in nude mice B16 melanoma models.

Abstract

Objective: To study the effect of Suiqing Pill (SQP)

a TCM compound drug that can activate blood circulation and get rid of blood stasis

while in the high-dose and low-dose SQP treated model mice

MVD was inhibited by 33.5% and 22.6% respectively (P<0.01

P<0.05). The strong positive protein expression of VEGF and MMP-2 in model control also reduced in the SQP treated groups.Conclusion: SQP could inhibit tumor angiogenesis

protein expression of VEGF and MMP-2 in nude mice B16 melanoma models.

关键词

Suiqing Pilltumor angiogenesisvascular endothelial growth factormatrix metalloproteinase

Keywords

Suiqing Pilltumor angiogenesisvascular endothelial growth factormatrix metalloproteinase

references

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Fontanimi G. Neoangiogenesis and P53 protein in lung cancer: their prognostic role and their relation with VEGF expression. Br J Cancer 1997; (9): 1295–1306.

Bussolino F, Mantovani A, Persico G, et al. Molecular mechanisms of blood vessel formation. Trends Biochem Sci 1997; 22(7): 251–255.

Zhang P. Assessment of tumor angiogenesis. Cancer Res Prev Treat 2001;28(1): 70–72.

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Wedner N, Carrall PR, Flax J, et al. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 1993; 143(2):401–409.

Pake JE, Keller GA, Lucarini G, et al. Vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix bound VECF. Mol Biol Cell 1993;4: 1317–1326.

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