Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland

Qian Li-qi; Pei Xiao-hua; Chen Rong-ming; Xu Zhi-yin

doi:10.1007/BF02836386

Your Location：

Home >

Browse articles >

Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland

OriginalPaper | Updated：2021-08-27

- Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland
- Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland
- 中国结合医学杂志（英文版） 2004年10卷第2期页码：131-134
- Affiliations：
  
  1. Nanjing Medical University,China
  2. Beijing University of Chinese Medicine,China
  3. Pharmaceutical Co. Ltd., Nanjing University of Traditional Chinese Medicine,China
  4. Jiangsu Provincial Hospital of Chinese Medicine,China
- Author bio：
- Funds：
  
  This study was supported by Jiangsu Provincial Administration Bureau of Traditional Chinese Medicine [No. SZ 95-B18]
- DOI：10.1007/BF02836386
  中图分类号：
- 纸质出版日期：2004，
Scan for full text
Li-qi, Q., Xiao-hua, P., Rong-ming, C. et al. Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland., Chin. J. Integr. Med. 10, 131–134 (2004). https://doi.org/10.1007/BF02836386

Qian Li-qi, Pei Xiao-hua, Chen Rong-ming, et al. Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland[J]. Chinese Journal of Integrative Medicine, 2004,10(2):131-134.
Li-qi, Q., Xiao-hua, P., Rong-ming, C. et al. Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland., Chin. J. Integr. Med. 10, 131–134 (2004). https://doi.org/10.1007/BF02836386 DOI：

Qian Li-qi, Pei Xiao-hua, Chen Rong-ming, et al. Effect of Lirukang oral liquid on neurotransmitters and estrogen in rats with hyperplasia of mammary gland[J]. Chinese Journal of Integrative Medicine, 2004,10(2):131-134. DOI： 10.1007/BF02836386.

摘要

Objective: To investigate the effects of Lirukang oral liquid (LRK) on release of neurotransmitter in rats with hyperplasia of mammary glands (HMG) and to explore its mechanism.Methods: Sixty rats were divided into six groups

the normal control group

the model control group

the large dosage (3.6g/kg) and the small dosage (1.8g/kg) LRK groups

the Ruzengning (RZN

2.5g/kg) group and the tamoxifen (TAM

5mg/kg) group

10 in each group. Except those in the normal control group

all the animals were made into rat model of HMG by intraperitoneal injection of estradiol benzoate. Levels of dopamine (DA) and 5-hydroxytryptamine (5-HT) in hypothalamus and mammary gland in rats were detected by fluorescence luminosity assay

and level of prolactin (PRL) in serum was detected by radioimmunoassay.Results: In the model group

the level of DA reduced significantly (P<0.01)

and 5-HT and PRL increased obviously (P<0.01). Compared with the model group

the LRK groups of both dosages and the TAM group had their level of DA significantly increased (P<0.01)

and level of 5-HT significantly decreased (P<0.01). The serum PRL in both LRK groups was significantly decreased (P<0.01). No obvious changes in DA

5-HT and PRL were found in the RZN group.Conclusion: LRK and TAM have similar effects in regulating the release of neurotransmitter in hypothalamus and mammary gland and serum content of estrogen in the animal models of HMG.

Abstract

the normal control group

the model control group

the large dosage (3.6g/kg) and the small dosage (1.8g/kg) LRK groups

the Ruzengning (RZN

2.5g/kg) group and the tamoxifen (TAM

5mg/kg) group

10 in each group. Except those in the normal control group

and level of prolactin (PRL) in serum was detected by radioimmunoassay.Results: In the model group

the level of DA reduced significantly (P<0.01)

and 5-HT and PRL increased obviously (P<0.01). Compared with the model group

the LRK groups of both dosages and the TAM group had their level of DA significantly increased (P<0.01)

and level of 5-HT significantly decreased (P<0.01). The serum PRL in both LRK groups was significantly decreased (P<0.01). No obvious changes in DA

关键词

Lirukang oral liquidhyperplasia of mammary glandsneurotransmitterrats

Keywords

Lirukang oral liquidhyperplasia of mammary glandsneurotransmitterrats

references

Duan YL, Zhang XM, Shen ZY, et al. Effect of three kinds of Chinese composite recipes (supplementing Shen, strengthening Pi and activating blood circulation) on content of monoamine transmitters in hypothalamus of rats Induced by intracerebroventricular injection of interleukin-1. Chin J Integr Tradit West Med 1999; 19 (3): 164–166.

Rao JC, Li LZ, Chen YS, et al. Duplication of animal model with hyperplasia of mammary glands and their pathological types. Chin J Pathophysiol 1992; 8(6): 671–672.

Zhu Y, Duo XY. Experimental animal models of diseases. Tianjin: Tianjin Technological Translation Publishing Company, 1997: 392

Cheng ZP. Endocrine Physiology. Beijing: People’s Medical Publishing House, 1984: 42, 70.

Maslar IA, Kaplan BM, Luciano AA, et al. Prolactin production by the endomertium of early human pregnancy. J Clin Endocrinol Metab 1980; 51: 70–75.

Zheng YC. Animal hormones and their application. Nanjing: Jiangsu Science & Technology Publishing House, 1996: 50.

Yu AF. Gynecologic and obstetric endocrinology (the last volume). Shanghai: Shanghai Science and Technology Publishing House, 1985: 30–33.

Zhou QL, Bao HY, Zhang YW, et al. Study of deerhorn on Treatment Rupi (nodules of breast): II. Study on mechanism of deerhorn extract in inhibiting hyperplasia of mammary glands. Pharmacol Clin Chin Materia Med 1998:14(3): 23–25.

Yang DH, Cai SQ, Wang X, et al. Inhibition of Radix Astragali and Radix polygoni multiflori on induction of thymocyte apoptosis by CTX. J China Pharm University 2000;31(1): 35–38.

Wang Y, Ma AL, Zhang HZ, et al. Experimental study on anticancer effects of oyster shell extracts. Chin J Marine Drugs 1997; 16(1): 18–22.

Wen L, Yuan J. Effects of Lijiang appendiculate cremastra pseudobulb. Chin J Ethomedicine &. Ethopharmacy 2003; 62(3): 180–181.

Yuan SJ, Han R. Chemical preventive effect of curcumin on cancer. Foreign Medical Sciences: Cancer Section 1997;24(5): 2664–268.

Qian LQ, Pei XH, Xu ZY. The effects of Lirukang oral liquid on integral condition of pathological model of hyperplasia of mammary glands. Acta of Nanjing University of TCM 2002; 18(3): 167–168

FULL TEXT LINK

More>

浏览量

410

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effect of acupuncture on proliferation and differentiation of neural stem cells in brain tissues of rats with traumatic brain injury

Effects of Fufang Shenhua Tablet (复方肾华片) on the expression of toll-like receptors during acute kidney injury induced by ischemia-reperfusion in rats

Scavenging effect of Naoerkang (脑尔康) on amyloid beta-peptide deposition in the hippocampus in a rat model of Alzheimer’s disease

Effect of Yiqi Huoxue Recipe (益气活血方) on cardiac function and ultrastructure in regression of pressure overload-induced myocardial hypertrophy in rats

Cardio-protective effects of Corocalm on acute myocardial ischemia/reperfusion injury in rats