Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV

Yang Zu-yi; Wu Xue-mei; Ou Ya-long; Yu Ping; Luo Jie; Song Xiu-yun

doi:10.1007/BF02836403

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Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV

OriginalPaper | Updated：2021-08-27

- Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV
- Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV
- 中国结合医学杂志（英文版） 2004年10卷第3期页码：181-186
- Affiliations：
  
  1. Sichuan Tumor Hospital,Chengdu,China
  2. Clinical Medicine College, Chengdu University of TCM,China
  3. Affiliated Hospital to Sichuan Academy of TCM,China
- Author bio：
- Funds：
- DOI：10.1007/BF02836403
  中图分类号：
- 纸质出版日期：2004，
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Zu-yi, Y., Xue-mei, W., Ya-long, O. et al. Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV., Chin. J. Integr. Med. 10, 181–186 (2004). https://doi.org/10.1007/BF02836403

Yang Zu-yi, Wu Xue-mei, Ou Ya-long, et al. Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV[J]. Chinese Journal of Integrative Medicine, 2004,10(3):181-186.
Zu-yi, Y., Xue-mei, W., Ya-long, O. et al. Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV., Chin. J. Integr. Med. 10, 181–186 (2004). https://doi.org/10.1007/BF02836403 DOI：

Yang Zu-yi, Wu Xue-mei, Ou Ya-long, et al. Effect of TCM combined with chemotherapy on immune function and quality of life of patients with non-small cell lung cancer in stage III-IV[J]. Chinese Journal of Integrative Medicine, 2004,10(3):181-186. DOI： 10.1007/BF02836403.

摘要

Objective: To observe and compare the effect of traditional Chinese medicine (TCM) combined with chemotherapy (CT) on immune function and quality of life (QOL)of patients with non-small cell lung cancer (NSCLC) in stage III-IV.Methods: One hundred cases with stage III-IV NSCLC were randomly divided into two groups. The treated group (n = 50) received CT combined with TCM

and the control group received CT alone. The percentage of T lymphocyte subset in peripheral blood and the change of natural killer (NK) cell count were observed after treatment. The QOL and tolerance of CT were also compared between the two groups after treatment. Results: In the treated group

CD3 cell count

CD4 cell count

CD4/ CD8 ratio and NK cell activity were higher than those in control group

while CD8 cell count in the treated group was lower than that in the control group (P<0.05)

and QOL and tolerance of CT in the treated group were also better (P<0.05).Conclusion: TCM combined with CT could raise the patients’ ability in tolerating CT in stage III-IV NSCLC.

Abstract

CD3 cell count

CD4 cell count

CD4/ CD8 ratio and NK cell activity were higher than those in control group

while CD8 cell count in the treated group was lower than that in the control group (P<0.05)

and QOL and tolerance of CT in the treated group were also better (P<0.05).Conclusion: TCM combined with CT could raise the patients’ ability in tolerating CT in stage III-IV NSCLC.

关键词

non-small cell lung cancer in stage III-IVtraditional Chinese medicine combined with chemotherapyimmune functionquality of life

Keywords

non-small cell lung cancer in stage III-IVtraditional Chinese medicine combined with chemotherapyimmune functionquality of life

references

Liu DX, Lu ZB. Cell biology study methods techniques. 2nd edition. Beijing: Beijing Medical University and Chinese Union Medical University Press, 1999: 167–178.

Wan ZH, Zhang CZ, Song YL, et al. Score of QOL of lung cancer patients FACT-C (Chinese edition). Chin Tumor 2000;9(3): 109–110.

Lu S, Shi CL, Cai YY, et al. Tumor and QOL. Mod Rehabil 2000; 4(9): 1284–1285.

Wang YX, Ruan CP, Li L. Change of 6 cell types of T cell surface and large intestine oncogene and relationship with operational type. Chin J Immunol 1998; 14 (2): 105–107.

Autel JP. Lymphocyte function and the role of regulator cells in multiple sclerosis. Neurol 1978;28: 106.

Liang YM, Liu HZ, Liu CF. Change of peripheral T cell subset after radiotherapy in treating esophageal cancer. Shanghai J Immunol 1998;18(3): 143–144.

Wu WM, Yang ZY, Song XY. Clinical study of immune function of III-IV stage lung cancer patients. Sichuan Tumor Prev Treat 2003;16(2): 88–89.

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