Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis

Shen Xiao-jun; Shi Yun-ju; Wang Ling

doi:10.1007/BF02836426

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Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis

OriginalPaper | Updated：2021-08-27

- Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis
- Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis
- 中国结合医学杂志（英文版） 2004年10卷第4期页码：263-266
- Affiliations：
  
  1. Henan Chinese Medical College,Zhengzhou
  2. School of Medicine, Zhengzhou Railway Advanced Professional College,China
  3. Medical Colloge, Zhengzhou University,China
- Author bio：
- Funds：
  
  Project supported by Science and Technology Committee of Zhengzhou Railway Department (No. 03W30)
- DOI：10.1007/BF02836426
  中图分类号：
- 纸质出版日期：2004，
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Xiao-jun, S., Yun-ju, S. & Ling, W. Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis., Chin. J. Integr. Med. 10, 263–266 (2004). https://doi.org/10.1007/BF02836426

Shen Xiao-jun, Shi Yun-ju, Wang Ling. Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis[J]. Chinese Journal of Integrative Medicine, 2004,10(4):263-266.
Xiao-jun, S., Yun-ju, S. & Ling, W. Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis., Chin. J. Integr. Med. 10, 263–266 (2004). https://doi.org/10.1007/BF02836426 DOI：

Shen Xiao-jun, Shi Yun-ju, Wang Ling. Effect of Tongmai Jiangzhi oral liquid on serum P-selectin, von Willebrand factors and D-dimer in patients with atherosclerosis[J]. Chinese Journal of Integrative Medicine, 2004,10(4):263-266. DOI： 10.1007/BF02836426.

摘要

Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis

and the effect of Tongmai Jiangzhi oral liquid (TMJZ) on cytokines through observing serum P-selectins (Ps)

von Willebrand (vWF)

and D-dimer (D-D) in atherosclerosis (AS) patients.Methods: Sixty-three AS patients were randomly divided into the treated group (n = 33

treated with TMJZ

10 ml each time

three times a day) and the control group (n = 30

treated with Lovastatin

10 mg

once daily). The levels of serum lipids (enzymatic methods)

vWF

and D-D were measured before and after 8 weeks of treatment.Results: Serum total cholesterol (TC)

triglyceride (TG)

low-density lipoprotein cholesterol (LDL-C)

apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 orP<0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TMJZ treatment. Serum Ps

vWF

and D-D also declined (P<0.05) after treatment. There was no significant difference between the treated and the control groups in these parameters except serum HDL-C level.Conclusion: TMJZ has good therapeutic effect in regulating serum lipids

improving endothelial cell function

inhibiting activation of platelets

and preventing the disturbance of blood coagulation/fibrinolysis function in patients with AS.

Abstract

Objective: To explore the role of cytokines on the pathogenesis of atherosclerosis

and the effect of Tongmai Jiangzhi oral liquid (TMJZ) on cytokines through observing serum P-selectins (Ps)

von Willebrand (vWF)

and D-dimer (D-D) in atherosclerosis (AS) patients.Methods: Sixty-three AS patients were randomly divided into the treated group (n = 33

treated with TMJZ

10 ml each time

three times a day) and the control group (n = 30

treated with Lovastatin

10 mg

once daily). The levels of serum lipids (enzymatic methods)

vWF

and D-D were measured before and after 8 weeks of treatment.Results: Serum total cholesterol (TC)

triglyceride (TG)

low-density lipoprotein cholesterol (LDL-C)

apo-protein B-100 (apoB-100) were significantly decreased (P<0.05 orP<0.01) and high-density lipoprotein cholesterol (HDL-C) was significantly raised (P<0.05) after TMJZ treatment. Serum Ps

vWF

improving endothelial cell function

inhibiting activation of platelets

and preventing the disturbance of blood coagulation/fibrinolysis function in patients with AS.

关键词

Tongmai Jiangzhi oral liquidatherosclerosisP-selectinvon Willebrand factorD-dimer

Keywords

Tongmai Jiangzhi oral liquidatherosclerosisP-selectinvon Willebrand factorD-dimer

references

Liang YJ. Cellular connective communication and atherosclerosis. Dev Cardiovasc Dis 2001; 22(3): 175–177.

Editorial Committee of Chinese Journal of Cardiovascular Diseases. Academic Committee of Prevention and Treatment on Abnormal Lipidemia. The suggestion of prevention and treatment on abnormal lipidemia. Chin J Cardiovasc Dis 1997; 25(3): 169–175.

Johnson-Tidey RR, McGregor JL, Taylor PR. Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques: co-expression with intercellular adhesion molecule-1. Am J Pathol 1994; 144: 952–961.

Kaikita K, Ogawa H, Yasue H, et al. Soluble P-Selectin is released into the coronary circulation after coronary spasm. Circulation 1995; 92: 1726–1730.

Lu JM. Dysfunction of vascular endothelium and its investigation in coronary heart disease. Dev Cardiovasc Dis 2000; 21(6): 339–342.

Zhang HP. Disseminated intravascular coagulation. In: Jin Hui-ming editor. Pathophysiology. 5th ed. Beijing: People’s Medical Publishing House, 137–149

Meng ZX, Wu SM, Sun RJ, et al. The mechanism of Radix Salviae miltiorrhizae in preventing and treating atherosclerosis. J Cardiovasc Pulm Dis 1993; 12(1): 121–123.

Zhou XM, Lu ZY, Wang DW. The preliminary study of Salvia on its effect and mechanism in preventing and treating experimental arterial restenosis. Chin J Integr Tradit West Med (Chin) 1996; 16(8): 480–482.

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