Clinical observation on treatment of senile rheumatoid arthritis by tripterygium polyglycosides combined with small dose of methotrexate

Shen Jie; Zhang Zhi-li

doi:10.1007/BF02836428

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Clinical observation on treatment of senile rheumatoid arthritis by tripterygium polyglycosides combined with small dose of methotrexate

OriginalPaper | Updated：2021-08-27

- Clinical observation on treatment of senile rheumatoid arthritis by tripterygium polyglycosides combined with small dose of methotrexate
- Clinical observation on treatment of senile rheumatoid arthritis by tripterygium polyglycosides combined with small dose of methotrexate
- 中国结合医学杂志（英文版） 2004年10卷第4期页码：271-274
- Affiliations：
  
  Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai
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- DOI：10.1007/BF02836428
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- 纸质出版日期：2004，
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Jie, S., Zhi-li, Z. Clinical observation on treatment of senile rheumatoid arthritis by tripterygium polyglycosides combined with small dose of methotrexate., Chin. J. Integr. Med. 10, 271–274 (2004). https://doi.org/10.1007/BF02836428

Shen Jie, Zhang Zhi-li. Clinical observation on treatment of senile rheumatoid arthritis by tripterygium polyglycosides combined with small dose of methotrexate[J]. Chinese Journal of Integrative Medicine, 2004,10(4):271-274.
Jie, S., Zhi-li, Z. Clinical observation on treatment of senile rheumatoid arthritis by tripterygium polyglycosides combined with small dose of methotrexate., Chin. J. Integr. Med. 10, 271–274 (2004). https://doi.org/10.1007/BF02836428 DOI：

Shen Jie, Zhang Zhi-li. Clinical observation on treatment of senile rheumatoid arthritis by tripterygium polyglycosides combined with small dose of methotrexate[J]. Chinese Journal of Integrative Medicine, 2004,10(4):271-274. DOI： 10.1007/BF02836428.

摘要

Objective: To observe the effect and adverse reaction of tripterygium polyglycosides (TP) combined with small dose of methotrexate (MTX) in treating senile rheumatoid arthritis (RA).Methods: Sixty old patients with RA were equally divided into two groups

the treated group was treated with oral intake of TP (10 mg three times per day) plus MTX (7.5 mg

once per week)

and the control group was treated with MTX (15 mg per week) respectively for 3 months. The changes from before to after treatment in resting pain

morning rigidity

bilateral grip strength

local tenderness index

arthroncus index

patient’s evaluation

doctor’s evaluation

erythrocyte sedimentation rate (ESR)

C-reaction protein (CRP) and rheumatoid factor(RF) titre were observed and the clinical therapeutic effect assessed.Results: The total effective rate in the treated group was 86.67% and that in the control group 83.33%

showing insignificant difference between them (P>0.05). But the improvement in local tenderness index

arthroncus index

morning rigidity and ESR in the treated group was significantly better than those in the control group (P<0.01 orP<0.05). The occurrence rate of adverse reaction in the treated group was 26.67%

which was lower than that in the control group (43.33%)

showing significant difference (P<0.01).Conclusion: TP combined with small dose of MTX is a favorable therapeutic method for treating senile RA.

Abstract

the treated group was treated with oral intake of TP (10 mg three times per day) plus MTX (7.5 mg

once per week)

and the control group was treated with MTX (15 mg per week) respectively for 3 months. The changes from before to after treatment in resting pain

morning rigidity

bilateral grip strength

local tenderness index

arthroncus index

patient’s evaluation

doctor’s evaluation

erythrocyte sedimentation rate (ESR)

showing insignificant difference between them (P>0.05). But the improvement in local tenderness index

arthroncus index

morning rigidity and ESR in the treated group was significantly better than those in the control group (P<0.01 orP<0.05). The occurrence rate of adverse reaction in the treated group was 26.67%

which was lower than that in the control group (43.33%)

showing significant difference (P<0.01).Conclusion: TP combined with small dose of MTX is a favorable therapeutic method for treating senile RA.

关键词

rheumatoid arthritistripterygium polyglycosidesmethotrexate

Keywords

rheumatoid arthritistripterygium polyglycosidesmethotrexate

references

Nesher G, Moore T, Zuckner J. Rheumatoid arthritis in elderly. J Am Geriatr Soc 1991; 39: 284–294.

Frank CA, Steven ME, Daniel AB, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthr Rheum 1988; 31: 315–324.

Jiang M, Zhu LP, Lin XY, editors. Rheumatology. Beijng: Science Press, 1995: 538.

Shi GY, Yuan GH, Senile rheumatoid arthritis. J Rheumatism 1997; 2(3): 3–5.

Tao XL, Sun Y, Dong Y, et al. Double-blinded study on the treatment of rheumatoid arthritis by Tripterygium polyglycosides. Chin J Intern Med 1987; 26(7): 399–402.

Weinblatt ME, Kaplan H, Germain BF. Methotrexate in rheumatoid arthritis: a five prospective multicentre study. Arthritis Rheum 1994; 37: 1492–1498.

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