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Clinical observation and mechanism study on treatment of senile dementia with Naohuandan
Clinical observation and mechanism study on treatment of senile dementia with Naohuandan
- 中国结合医学杂志（英文版） 2005年11卷第2期 页码：111-116
- Affiliations：
Department of TCM, The Second Hospital Affiliated to Sun Yet-san University,Guangzhou
- Author bio：
- Funds：Supported by the Research Fund from Guangdong Provincial Administration of TCM (No. A002003002)
DOI：10.1007/BF02836466
中图分类号：纸质出版日期：2005，
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Rong-sen, M., Qing-ming, L., Chang-xiu, W. et al. Clinical observation and mechanism study on treatment of senile dementia with Naohuandan., Chin. J. Integr. Med. 11, 111–116 (2005). https://doi.org/10.1007/BF02836466
Meng Rong-sen, Li Qing-ming, Wei Chang-xiu, et al. Clinical observation and mechanism study on treatment of senile dementia with Naohuandan[J]. Chinese Journal of Integrative Medicine, 2005,11(2):111-116.
Rong-sen, M., Qing-ming, L., Chang-xiu, W. et al. Clinical observation and mechanism study on treatment of senile dementia with Naohuandan., Chin. J. Integr. Med. 11, 111–116 (2005). https://doi.org/10.1007/BF02836466 DOI：
Meng Rong-sen, Li Qing-ming, Wei Chang-xiu, et al. Clinical observation and mechanism study on treatment of senile dementia with Naohuandan[J]. Chinese Journal of Integrative Medicine, 2005,11(2):111-116. DOI： 10.1007/BF02836466.
摘要
Objective: To observe the therapeutic effect and mechanism of Naohuandan (NHD) in treating senile dementia (SD).Methods: Clinical study: Fifty-eight patients with SD
whose diagnosis conforms to the Diagnostic Standard of DSM-IV issued by American Association of Psychiatry
were enrolled and randomly assigned into two groups. The 30 patients in the treated group were treated with NHD
4 capsules each time
3 times daily. The 28 patients in the control group were treated with Piracetam
1. 6 g each time
3 times daily. The therapeutic course for both groups was 3 months. The therapeutic efficacy was estimated and compared by comprehensive scores of memory and cognition
scores of Mini-mental State Examination (MMSE) and Activities of Daily Living (ADL). Experimental study: Rats were divided into the control group
the model group and the high-dosage and low-dosage NHD treated groups. The protective effect of NHD on the per-oxidative damage of hippocampal neurons in β-amyloid protein induced SD model was observed and the related criteria were determined.Results: Clinical study showed that both NHD and Piracetam could improve the clinical symptoms of patients
the two medicines showing insignificant difference in total effective rate. But NHD was better in elevating MMSE score and lowering ADL score in patients than Piracetam (P< 0.05 andP<0.01). Experimental study showed that (1) 24 and 72 hrs after modeling
the activity of SOD and GSH were lower and the level of MDA higher in the model group than those in the control group (P<0.05 orP<0. 01). Compared with the model group at the corresponding time points
in the high-dosage NHD group
SOD and GSH were higher
MDA was lower (P<0. 05 orP<0. 01); but in the low-dosage NHD group
SOD at the 72th hr was higher (P<0.05) and MDA at 24th and 72th hrs was lower (P<0.01). And most of the criteria in the high-dosage NHD group was improved better than that in the low-dosage NHD group. (2) The survival rates of neurons in various groups were not different significantly (P>0.05) 24 hrs after modeling
but that in the high-dosage NHD group was significantly higher than that in the model group (P<0.01) and in the low-dosage NHD group 72 hrs after modeling(P<0.05).Conclusion: NHD is an effective Chinese herbal preparation for treatment of SD
and its mechanism is related with its inhibition on peroxidative injury and protection on neurons.
Abstract
Objective: To observe the therapeutic effect and mechanism of Naohuandan (NHD) in treating senile dementia (SD).Methods: Clinical study: Fifty-eight patients with SD
whose diagnosis conforms to the Diagnostic Standard of DSM-IV issued by American Association of Psychiatry
were enrolled and randomly assigned into two groups. The 30 patients in the treated group were treated with NHD
4 capsules each time
3 times daily. The 28 patients in the control group were treated with Piracetam
1. 6 g each time
3 times daily. The therapeutic course for both groups was 3 months. The therapeutic efficacy was estimated and compared by comprehensive scores of memory and cognition
scores of Mini-mental State Examination (MMSE) and Activities of Daily Living (ADL). Experimental study: Rats were divided into the control group
the model group and the high-dosage and low-dosage NHD treated groups. The protective effect of NHD on the per-oxidative damage of hippocampal neurons in β-amyloid protein induced SD model was observed and the related criteria were determined.Results: Clinical study showed that both NHD and Piracetam could improve the clinical symptoms of patients
the two medicines showing insignificant difference in total effective rate. But NHD was better in elevating MMSE score and lowering ADL score in patients than Piracetam (P< 0.05 andP<0.01). Experimental study showed that (1) 24 and 72 hrs after modeling
the activity of SOD and GSH were lower and the level of MDA higher in the model group than those in the control group (P<0.05 orP<0. 01). Compared with the model group at the corresponding time points
in the high-dosage NHD group
SOD and GSH were higher
MDA was lower (P<0. 05 orP<0. 01); but in the low-dosage NHD group
SOD at the 72th hr was higher (P<0.05) and MDA at 24th and 72th hrs was lower (P<0.01). And most of the criteria in the high-dosage NHD group was improved better than that in the low-dosage NHD group. (2) The survival rates of neurons in various groups were not different significantly (P>0.05) 24 hrs after modeling
but that in the high-dosage NHD group was significantly higher than that in the model group (P<0.01) and in the low-dosage NHD group 72 hrs after modeling(P<0.05).Conclusion: NHD is an effective Chinese herbal preparation for treatment of SD
and its mechanism is related with its inhibition on peroxidative injury and protection on neurons.
关键词
senile dementiaNaohuandanamyloid proteinperoxidative injury
Keywords
senile dementiaNaohuandanamyloid proteinperoxidative injury
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