The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin

Deng Yin-quan; Fan Xiao-fen; Li Jian-ping

doi:10.1007/BF02836467

Your Location：

Home >

Browse articles >

The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin

OriginalPaper | Updated：2021-08-27

- The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin
- The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin
- 中国结合医学杂志（英文版） 2005年11卷第2期页码：117-122
- Affiliations：
  
  First Affiliated Hospital, Medical College of Zhejiang University,Hangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02836467
  中图分类号：
- 纸质出版日期：2005，
Scan for full text
Yin-quan, D., Xiao-fen, F. & Jian-ping, L. The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin., Chin. J. Integr. Med. 11, 117–122 (2005). https://doi.org/10.1007/BF02836467

Deng Yin-quan, Fan Xiao-fen, Li Jian-ping. The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin[J]. Chinese Journal of Integrative Medicine, 2005,11(2):117-122.
Yin-quan, D., Xiao-fen, F. & Jian-ping, L. The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin., Chin. J. Integr. Med. 11, 117–122 (2005). https://doi.org/10.1007/BF02836467 DOI：

Deng Yin-quan, Fan Xiao-fen, Li Jian-ping. The state of insulin resistance in patients with nonalcoholic fatty liver and the intervention with Gankangyin[J]. Chinese Journal of Integrative Medicine, 2005,11(2):117-122. DOI： 10.1007/BF02836467.

摘要

Objective: To explore the correlation of nonalcoholic fatty liver (NAFL) with insulin resistance and the intervention of it by Gankangyin(GKY).Methods: Ninety-six patients with NAFL were randomly assigned into the treated group and the control group. They were treated with GKY and Silymarin for 3 months respectively. Oral glucose tolerance test (OGTT) and insulin release test (IRT) were conducted and insulin sensitivity indexes were determined before and after treatment. And 32 healthy nonalcoholic persons were enrolled and used as the healthy control group.Results: Before treatment

the levels of blood glucose and insulin at different time points in OGTT test

and the insulin resistance index (IRI) were significantly higher (P<0.05 orP<0.01) while insulin sensitivity index (ISI) and insulin active index (IAI) were lower (P<0.05 orP<0.01) in the NAFL patients than those in the healthy persons. After treatment

the above-mentioned raised criteria were significantly lowered (P<0.05

P<0.01) and the lowered criteria were significantly increased (P<0.01) in the treated group

while in the control group all the criteria were insignificantly changed (P>0. 05).Conclusion: Evident insulin resistance exists in NAFL patients. GKY could’increase the insulin sensitivity

thus improving the state of insulin resistance in NAFL patients.

Abstract

the levels of blood glucose and insulin at different time points in OGTT test

the above-mentioned raised criteria were significantly lowered (P<0.05

P<0.01) and the lowered criteria were significantly increased (P<0.01) in the treated group

while in the control group all the criteria were insignificantly changed (P>0. 05).Conclusion: Evident insulin resistance exists in NAFL patients. GKY could’increase the insulin sensitivity

thus improving the state of insulin resistance in NAFL patients.

关键词

nonalcoholic fatty liverinsulin resistanceGankangyin

Keywords

nonalcoholic fatty liverinsulin resistanceGankangyin

references

Chen WX, Yu ZH, Li YM, et al. The relationship between nonalcoholic fatty liver and insulin resistance with abnormal glucose metabolism. Chin J Hepatol 2000; 8 (2): 76–77.

Gu MY. Insulin resistance and fatty liver. Foreign Med Sci (Fascicle Endocrine) 2003;23(suppl): 32–33.

Zheng GY, Hong HS, Wang YB, et al. Study on relationship between insulin resistance and syndrome differentiation of traditional Chinese medicine in hypertriglyceridemia. Chin J Integr Tradit West Med (English) 2001; 8(5): 281–283.

Huang JS, Bai JC, Huang GL, et al. Relationship between serum insulin, C-peptide in hypertension patients and syndrome differentiation-typing in TCM. Chin J Integr Tradit West Med (Chin) 2000; 20 (3): 190–191.

Yu W, Gao YY, Zhang X. Clinical observation on improving senile postprandial hyperglycemia and insulin sensitivity with combination of acarbose and Liuwei Nengxiao Capsule. Chin J Integr Tradit West Med (Chin) 2004; 24(5): 396–399.

Zhu LQ, Liu YH, Huang M, et al. Study on improvement of islet β cell function in patients with latent autoimmune diabetes mellitus in adults by integrative Chinese and Western medicine. Chin J Integr Tradit West Med (Chin) 2004; 24(7): 581–584.

Chinese Association of Hepatology and Study Group of Alcohol Hepatology. Diagnosis standard of nonalcoholic fatty liver (draft). Chin J Hepatol 2001; 9(6): 325.

Wu B, Cheng H, Fu M, et al. The association between fasting serum leptin and specific insulin, proinsulin and insulin sensitivity in different glucose tolerance individuals. Chin J Endocrinol Metab 2002; 18 (3): 169–172.

Li XJ. Insulin resistance syndrome. Beijing: People’s Medical Publishing House, 2001: 50.

Fan JG. Metabolic syndrome and fatty liver. Foreign Med Sci (Fascicle Endocrine) 2002;22(5): 273–275.

Lu LG, Zeng MD. The role of improving insulin-resistant in the treatment and prevention of nonalcoholic fatty liver disease. Chin J Hepatol 2003; 11(2): 113–113.

Gao B. Antioxidation and light protection of substance which was cursorily distilled from leaf of Cudweed and central flavone compound. Foreign Med Sci (Plant Med) 2003; 18(1): 28–29.

Li J, Feng J. Study summary of pharmacological effect of antihypertension and concurrently antihyperlipemia of solo Chinese traditional and herbal drugs. Shizhen TCM Res J 1997;8(1): 69–70.

Li M. Research advance in chemical ingredient and pharmacological effect of Mung bean. Shanghai J Tradit Chin Med 2001;35(5): 47-cover 3.

Guo QS. Study headway of Pinellia tuber. Study Inform Chin Tradit Med 2000;2(10): 15–20.

Su XZ, Wang Y, Cao HJ. Study headway of pharmacological effect on Chinese Thorowax Root. Heilongjiang Med J 2000; 13(5): 297.

Zhang H, Yang QQ. Experimental study of prevention and cure diabetes mellitus by Chinese traditional and herbal drugs and its ingredient. Shizhen J TCM Res 1997; 8(1): 71–72.

Huang W, Yang YF. Pharmacological and clinical research progression of Privet Berry and its active ingredient. Modern J Integr Tradit Chin West Med 2003; 12 (7): 772–774.

Sun GL, Bian HR. The latest study headway of tall peduncle Fiveleaf Gynostemma Herb and Fiveleaf Gynostemma Herb. Chin J Pract Integr Tradit West Med 2003; 16(12): 1823–1824.

FULL TEXT LINK

More>

浏览量

405

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Ping-tang Recipe (平糖方) improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats

Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path

Effects of Bushen Tongmai Recipe (补肾通脉方) on protein kinase Bα expression in polycystic ovary rats with insulin resistance

Preliminary comparative study on the effect of different chinese drugs for strengthening Pi (脾) in antagonizing diet induced obesity

Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution