Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase

Hong Min-li; Yang Guo-zong; Chen Wen-xi; Gao Ling-yun; Cai Shao-hang; Dai Shun-zhen

doi:10.1007/BF02836500

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Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase

OriginalPaper | Updated：2021-08-27

- Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase
- Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase
- 中国结合医学杂志（英文版） 2005年11卷第3期页码：179-182
- Affiliations：
  
  Zhangzhou Hospital of Traditional Chinese Medicine,Fujian
- Author bio：
- Funds：
  
  Supported by Young Scientific Research Fund of Department of Public Health of Fujian Province (No. 99-1-22);Imbursement Project of Office of Science and Technology of Zhangzhou (No. Z02048)
- DOI：10.1007/BF02836500
  中图分类号：
- 纸质出版日期：2005，
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Min-li, H., Guo-zong, Y., Wen-xi, C. et al. Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase., Chin. J. Integr. Med. 11, 179–182 (2005). https://doi.org/10.1007/BF02836500

Hong Min-li, Yang Guo-zong, Chen Wen-xi, et al. Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase[J]. Chinese Journal of Integrative Medicine, 2005,11(3):179-182.
Min-li, H., Guo-zong, Y., Wen-xi, C. et al. Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase., Chin. J. Integr. Med. 11, 179–182 (2005). https://doi.org/10.1007/BF02836500 DOI：

Hong Min-li, Yang Guo-zong, Chen Wen-xi, et al. Effect of Yufeining on induced sputum interleukin-8 in patients with chronic obstructive pulmonary disease at the stable phase[J]. Chinese Journal of Integrative Medicine, 2005,11(3):179-182. DOI： 10.1007/BF02836500.

摘要

Objective: To evaluate the effect of Yufeining

a traditional Chinese medicine

on induced sputum interleukin-8 (IL-8) in patients with chronic obstructive pulmonary disease (COPD) at the stable phase.Methods: Thirty-six patients with COPD were divided into trial group (18 cases) and control group (18 cases) randomly. The trial group was treated with Yufeining pills taken orally for half a year; the control group was not given any medicine. Routine lung function was recorded before and after treatment. Total cell count (TCC)

differential cell counts (DCCs) and IL-8 in induced sputum were determined at the baseline and 6 months later.Results: The indices of lung function improved significantly after 6 months’ treatment in trial group (P<0.05); TCC and absolute neutrophil count decreased significantly compared with baseline in the trial group (P<0.05); Sputum IL-8 concentration dropped significantly after 6 months’ treatment

from a mean of 5.216 ± 2. 914 μg/L to 4.222 ± 2.140 μg/L (P<0.05). There were insignificant changes in the parameters in the control group between baseline and 6 months later.Conclusion: Yufeining could improve lung function

decrease sputum TCC

absolute neutrophil count and IL-8 concentration

and relieve airway inflammation in patients with COPD in the stable phase.

Abstract

Objective: To evaluate the effect of Yufeining

a traditional Chinese medicine

decrease sputum TCC

absolute neutrophil count and IL-8 concentration

and relieve airway inflammation in patients with COPD in the stable phase.

关键词

Chronic Obstructive Pulmonary Diseaseairway inflammationinterleukin-8Yufeining

Keywords

Chronic Obstructive Pulmonary Diseaseairway inflammationinterleukin-8Yufeining

references

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Respiratory Medicine Branch of Chinese Medical Association. The guideline of diagnosis and management for COPD (draft). Chin J Tuberc Respir Dis (Chin) 1997;20(4): 199–203.

Zheng XY. The clinical research guideline of traditional Chinese medicine and new drugs (draft). 1st ed. Beijing: Scientific and Technological Press of Traditional Chinese Medicine and Pharmacy, 2002: 390–392.

Nightingale JA, Rogers DF, Barnes PJ. Effect of repeated sputum induction on cell counts in normal volunteers. Thorax 1998;53: 87–90.

Caramori G, Romagnoli M, Casolari P, et al. Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations. Thorax 2003;58: 348–351.

Hong ML, Chen WX, Cai SH, et al. The interventional effects of Yufeining on lung function in patients with chronic obstructive pulmonary disease. Chin J Tradit Chin Med Pharmacy 2005;20(2): 92–95.

State Administration of Traditional Chinese Medicine. Advanced textbook on traditional Chinese medicine and pharmacology. 1st ed. Beijing: New World Press, 1995: 300–302, 467–472.

Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (COLD) Workshop summary. Am J Respir Crit Care Med 2001;163: 1256–1276.

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