Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats

Wu Su-hui; Sun Jing-fen; Guo Shu-zhen

doi:10.1007/BF02836506

Your Location：

Home >

Browse articles >

Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats

OriginalPaper | Updated：2021-08-27

- Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats
- Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats
- 中国结合医学杂志（英文版） 2005年11卷第3期页码：205-208
- Affiliations：
  
  Department of Obstetrics and Gynecology, The First Hospital, Shanxi Medical University,Taiyuan
- Author bio：
- Funds：
  
  Supported by Shanxi Key Technology R&D Program (No. 20022074)
- DOI：10.1007/BF02836506
  中图分类号：
- 纸质出版日期：2005，
Scan for full text
Su-hui, W., Jing-fen, S. & Shu-zhen, G. Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats., Chin. J. Integr. Med. 11, 205–208 (2005). https://doi.org/10.1007/BF02836506

Wu Su-hui, Sun Jing-fen, Guo Shu-zhen. Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats[J]. Chinese Journal of Integrative Medicine, 2005,11(3):205-208.
Su-hui, W., Jing-fen, S. & Shu-zhen, G. Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats., Chin. J. Integr. Med. 11, 205–208 (2005). https://doi.org/10.1007/BF02836506 DOI：

Wu Su-hui, Sun Jing-fen, Guo Shu-zhen. Effect of Compound Recipe Gengniankang on senile sexual hormone and expression of estrogen receptor in bone of climacteric female rats[J]. Chinese Journal of Integrative Medicine, 2005,11(3):205-208. DOI： 10.1007/BF02836506.

摘要

Objective: To compare the therapeutic effect of Compound Recipe Gengniankang (GNK) with that of hormone replacement treatment (HRT) on climacteric female rats with osteoporosis

and to investigate the roles of estrogen and estrogen receptors in the mechanism of osteoporosis.Methods: Climacteric female rats with osteoporosis were chosen and divided into three groups (GNK group

HRT group and control group). Apoptosis of ovarian granulose cells was measured by terminal-deoxynucleotidyl transferae mediated nick end labeling (TUNEL) assay. Serum level of estrdiol (E2)

follicle stimulating hormone (FSH)

luteinizing hormone (LH) were determined by the method of radioimmunoassay (RIA). Reverse transcriptase polymerase chain reaction (RT-PCT) technology was used to evaluate the expression of estrogen receptor (ER) in bone. Bone mineral density (BMD) was measured by double energy X-ray absorption (DEXA).Results: In the climacteric rats

BMD

serum E2

ER mRNA expression in bone decreased remarkably

and serum FSH

LH and apoptosis of ovarian granulose cells increased obviously. After treating with GNK

all the indexes were reversed except serum E2. The increase of E2 was not significant.Conclusion: GNK is effective on climacteric osteoporosis female rats. Its role is performed not by increasing serum E2 but by enhancing ER in the bone and inhibiting apoptosis of ovarian granulose cells. GNK can deter further exhaustion of ovarian function.

Abstract

Objective: To compare the therapeutic effect of Compound Recipe Gengniankang (GNK) with that of hormone replacement treatment (HRT) on climacteric female rats with osteoporosis

HRT group and control group). Apoptosis of ovarian granulose cells was measured by terminal-deoxynucleotidyl transferae mediated nick end labeling (TUNEL) assay. Serum level of estrdiol (E2)

follicle stimulating hormone (FSH)

BMD

serum E2

ER mRNA expression in bone decreased remarkably

and serum FSH

LH and apoptosis of ovarian granulose cells increased obviously. After treating with GNK

关键词

Compound Recipe GengniankangOsteoporosisestrogenestrogen receptor

Keywords

Compound Recipe GengniankangOsteoporosisestrogenestrogen receptor

references

Huber J. Phytoestrogens and SERMS, alternatives to classical hormone therapy? Ther Umsch 2000;57(10): 651–654.

Zhi HY, Li E. Effects of replenishing herbs and recipes on ER expression of bone tissue on ovariectomized rats osteoporosis. Chin J TCM Bas Med 2001;7 (4): 281–284.

Riggs BL, Hartmann LC. Selective estrogen-receptor modulators-mechanisms of action and application to clinical practice. N Engl J Med 2003;348(7): 618–629.

American College of Obstetricians and Gynecologists Committee on Practice Bulletins — Gynecology. ACOG Practice Bulletin. Selective estrogen receptor modulators. Int J Gynaecol Obstet 2002; 79(3): 289–298.

Tremollieres F, Lopes P. Specific estrogen receptor modulators (SERMs). Presse Med 2002;31 (28): 1323–1328.

Littleton-Kearney MT, Ostrowski NL, Cox DA, et al. Selective estrogen receptor modulators: tissue actions and potential for CNS protection. CNS Drug Rev 2002;8(3): 309–330.

Goldstein SR, Nanavati N. Adverse events that are associated with the selective estrogen receptor modulator levormeloxifene in an aborted phase III osteoporosis treatment study. Am J Obstet Gynecol 2002;187(3): 521–527.

Sandberg K. HRT and SERMs: the good, the bad … and the lovely? Trends Endocrinol Metab 2002;13(8): 317–318.

Dowsett M, Bundred NJ, Decensi A, et al. Effect of raloxifene on breast cancer cell Ki67 and apoptosis: a double-blind, placebo-controlled, randomized clinical trial in postmenopausal patients. Cancer Epidemiol Biomarkers Prev 2001;10(9): 961–966.

Cummings SR, Duong T, Kenyon E, et al. Serum estradiol level and risk of breast cancer during treatment with raloxifene. JAMA 2002;287(2): 216–20.

Sirtori CR. Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis. Drug Saf 2001;24(9): 665–682.

Xie L, Guo ZQ, Yao GH. TCM syndrome differentiation analysis after osteoporosis of climacterium. Chin J Med Pharmaceut 1999;14(3): 35–39.

FULL TEXT LINK

More>

浏览量

426

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion

Effects of different extracts of kanggushu (抗骨疏) on osteoporosis in model rats and the underlying mechanisms

Effect of oviductus ranae and oviductus ranae eggs on bone metabolism and osteoporosis

Study of osteoporosis treatment principles used historically by ancient physicians in Chinese Medicine

Epimedium-derived flavonoids modulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats via Wnt/β-catenin signal pathway activation