Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers

Li Bei; Shang Jing-chuan; Zhou Qi-xin

doi:10.1007/BF02836508

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Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers

OriginalPaper | Updated：2021-08-27

- Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers
- Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers
- 中国结合医学杂志（英文版） 2005年11卷第3期页码：217-221
- Affiliations：
  
  1. Department of Pharmacology, Chongqing University of Medical Sciences,Chongqing
  2. Department of Chemistry, Chongqing University of Medical Sciences,China
- Author bio：
- Funds：
  
  Supported by Chongqing Board of Health (2004-B-31)
- DOI：10.1007/BF02836508
  中图分类号：
- 纸质出版日期：2005，
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Bei, L., Jing-chuan, S. & Qi-xin, Z. Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers., Chin. J. Integr. Med. 11, 217–221 (2005). https://doi.org/10.1007/BF02836508

Li Bei, Shang Jing-chuan, Zhou Qi-xin. Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers[J]. Chinese Journal of Integrative Medicine, 2005,11(3):217-221.
Bei, L., Jing-chuan, S. & Qi-xin, Z. Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers., Chin. J. Integr. Med. 11, 217–221 (2005). https://doi.org/10.1007/BF02836508 DOI：

Li Bei, Shang Jing-chuan, Zhou Qi-xin. Study of total alkaloids from Rhizoma Coptis Chinensis on experimental gastric ulcers[J]. Chinese Journal of Integrative Medicine, 2005,11(3):217-221. DOI： 10.1007/BF02836508.

摘要

Objective: To study the effects of total alkaloids (TA) extracted from Rhizoma Coptis Chinensis on experimental gastric ulcer models.Methods: Four kinds of experimental ulcer models were established respectively by water-immersion stress

intragastric ethanol

acetic acid erosion

and pylorus ligation. The anti-ulcer effects of TA were evaluated

and compared with that of berberine (Ber) and cimetidine (Cim).Results: TA showed significant inhibitory effects on ulcerative formation induced by water-immersion stress

intragastric ethanol

and pylorus ligation in dose-dependent manner

and showed therapeutic effect on acetic acid erosion-inducing ulcer

in comparison with the control group. The anti-ulcer activity of Ber was less than TA containing equal content of Ber. TA significantly reduced the free acidity

total acidity and total acid output

but didn’t affect the gastric juice volume

gastric pepsin activity

adherent mucus quantity of stomach wall and free mucus dissolving in gastric juice. The suppressive activities of TA on gastric acid secretion didn’t occur when it was administered into dodecadactylon at a dose of 360 mg/kg wt. Moreover

when compared with Cim

the inhibitory effect of TA on gastric acid secretion isn’t proportional to the inhibitory effects on the formation of the 4 kinds of experimental ulcers.Conclusion: TA is a potent candidate in therapeutic drugs for treating gastric ulcer. Its anti-ulcer effective components and mechanism is not only related to Ber and inhibition of gastric acid

but also to other ingredients of TA and mechanism so far unknown.

Abstract

intragastric ethanol

acetic acid erosion

and pylorus ligation. The anti-ulcer effects of TA were evaluated

and compared with that of berberine (Ber) and cimetidine (Cim).Results: TA showed significant inhibitory effects on ulcerative formation induced by water-immersion stress

intragastric ethanol

and pylorus ligation in dose-dependent manner

and showed therapeutic effect on acetic acid erosion-inducing ulcer

in comparison with the control group. The anti-ulcer activity of Ber was less than TA containing equal content of Ber. TA significantly reduced the free acidity

total acidity and total acid output

but didn’t affect the gastric juice volume

gastric pepsin activity

when compared with Cim

but also to other ingredients of TA and mechanism so far unknown.

关键词

peptic ulcerRhizoma Coptis Chinensistotal alkaloidspharmacology

Keywords

peptic ulcerRhizoma Coptis Chinensistotal alkaloidspharmacology

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