
FOLLOWUS
1. Department of Clinical Medicine, Medical College, Jinan University,Guangzhou
2. Department of Traditional Chinese Medicine, Medical College, Jinan University,Guangzhou
纸质出版日期:2005,
Scan for full text
Fang, X., Xiao-yin, C. Effect of intestinal cytochrome P450 3A on phytochemical presystemic metabolism., Chin. J. Integr. Med. 11, 232–236 (2005). https://doi.org/10.1007/BF02836512
Xia Fang, Chen Xiao-yin. Effect of intestinal cytochrome P450 3A on phytochemical presystemic metabolism[J]. Chinese Journal of Integrative Medicine, 2005,11(3):232-236.
Fang, X., Xiao-yin, C. Effect of intestinal cytochrome P450 3A on phytochemical presystemic metabolism., Chin. J. Integr. Med. 11, 232–236 (2005). https://doi.org/10.1007/BF02836512 DOI:
Xia Fang, Chen Xiao-yin. Effect of intestinal cytochrome P450 3A on phytochemical presystemic metabolism[J]. Chinese Journal of Integrative Medicine, 2005,11(3):232-236. DOI: 10.1007/BF02836512.
Phytochemicals
orally administered substances
are found to undergo presystemic metabolism mainly in the intestine. Although early researches confirmed the role of intestinal bacteria in phytochemical presystemic metabolism
along with the development of molecular biology in investigating intestinal metabolism
a breakthrough has been won in research into metabolizing enzymes and transporters in intestine
which demands more attention and further studies. Recently
Cytochrome P450 3A has been found to be the most effective enzyme in mediating both oxidative (Phase I) and conjugative (Phase II) metabolism in the intestine. The present review summarizes the current findings correlated with the effect of intestinal cytochrome P450 3A on phytochemical presystemic metabolism
which provides a good basis for further research on phytochemical pharmacokinetics.
Phytochemicals
orally administered substances
are found to undergo presystemic metabolism mainly in the intestine. Although early researches confirmed the role of intestinal bacteria in phytochemical presystemic metabolism
along with the development of molecular biology in investigating intestinal metabolism
a breakthrough has been won in research into metabolizing enzymes and transporters in intestine
which demands more attention and further studies. Recently
Cytochrome P450 3A has been found to be the most effective enzyme in mediating both oxidative (Phase I) and conjugative (Phase II) metabolism in the intestine. The present review summarizes the current findings correlated with the effect of intestinal cytochrome P450 3A on phytochemical presystemic metabolism
which provides a good basis for further research on phytochemical pharmacokinetics.
phytochemicalsintestinal cytochrome P450 3Apresystemic metabolism
phytochemicalsintestinal cytochrome P450 3Apresystemic metabolism
Omura T. Forty years of cytochrome P450. Biochem Biophys Commun 1999; 266: 690–698.
Nelson DR. Cytochrome P450 and the individuality of species. Arch Biochem Biophys 1999; 369: 1–10.
Watkins PB, Wrighton SA, Schuetz EG, et al. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mu- cosa of rats and man. J Clin Invest 1987; 80: 1029–1036.
Domanski TL, Finta C, Halpert JR, et al. cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol 2001; 59: 386–392.
Lewis DF, Eddershaw PJ, Goldfarb PS, et al. Molecular modeling of CYP3A4 from an alignment with CYP102: identification of key interactions between putative active site residues and CYP3A-specific chemicals. Xenobiotica 1996; 26: 1067–1086.
Shimada T, Yamazaki H, Mimura M, et al. Interindividual variations in human liver cytochrome P-450 enzyme involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270: 414–423.
Kolars JC, Lown KS, Schmiedlin-Ren P, et al. CYP3A gene expression in human gut epithelium. Pharmacogenetics 1994; 4: 247–259.
Paine MF, Khalighi M, Fishe JM, et al. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J Pharmacol Exp Ther 1997; 283: 1552–1562.
Benet LZ, Kroetz DL, Sheiner LB. The dynamics of drug absorption, distribution, and elimination. Goodman & Gilman’s The Phamacological Basis of Therapeutics. Hardman JG, Lim-bird LE, Molimoff PB. eds. 9th ed. New York: McGraw-Hill, 2000: 3–28.
Paine MF, Shen DD, Kunze KL, et al. First-pass metabolism of midazolam by the human intestine. Clin Pharmacol Ther 1996; 60: 14–24.
Kolars JC, Awni WM, Merion RM, et al. First-pass metabolism of cyclosporin by the gut. Lancet 1991; 338: 1488–1490.
Carolyn L Cummins, Laurent Salphati, Michael J Reid, et al.In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. J Pharmacol Experi Ther 2003; 305 (l): 306–314.
Ambudkar SV, Dey S, Hrycyna CA, et al. Biochemical, cellular and pharmacological aspects of the multidrug transporter. Ann Rev Pharmacol Toxicol 1999; 39: 361–398.
Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995; 13: 129–1234.
Wacher VJ, Silverman JA, Zhang Y, et al. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidominetics. J Pharm Sci 1998; 87: 1322–1330.
Carolyn LC. Examining the interactive nature of cytochrome P450 3A4 and P-glycoprotein in intestinal drug metabolism. Dissert Abstr Int 2002; 63 (4): 1855.
Paavo Honkakoski, Masahiko Negishi. Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 2000; 347: 321–337.
Diao YY, He P, Wu MC, et al. The inducing effect of glycyrrhizin on itself in mice. J Chin Materia Medica 1999, 24 (9): 564–565.
Cheng JF, Teng SB, Chen DH, et al. Effect of glycyrrhizin and phenobarbital pretreatment of hepatic P450 3A enzyme in mice. J Fourth Milt Med Univ 2000, 21 (8): 968–971.
Wang Z, Kurosaki Y, Nakayama T, et al. Mechanism of gas-trointestinal absorption of glycyrrhizin in rats. Biol Pharm Bull 1994; 17 (10): 1399–1403.
Wu XC, Li Q, Xin HW, et al. The pharmacokinetics of enhancement of cyclosporin A by berberine chloride co-administrated in renal transplanted recipients. Asian J Drug Metab Pharmacokinet 2001, 1 (4): 257–261.
Xin HW, Wu XC, Li Q, et al. Effects of berberine chloride and co-administration with cyclosporin on CYP3A1 in rat liver and small intestine. Chin J Clin Pharmacol Ther 2004, 9 (5): 564–568.
Walter-Sack I, Klotz U. Influence of diet and nutritional status on drug metabolism. Clin Pharmacokinet 1996; 31 (7): 47–64.
Sigusch H, Henschel L, Kraul H, et al. Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects. Pharmazie 1994, 49: 675–679.
Lundahl J, Regardh CG, Edgar B, et al. Effects of grapefruit juice ingestion-pharmacokinetic and haemodynamics of intravenously and orally administered felodipine in healthy men. Eur J Clin Pharmacol 1997; 52: 139–145.
Kupferschmidt HH, Ha HR, Ziegler WH, et al. Interaction between grapefruit juice and midazolam in humans. Clin Pharmacol Ther 1995; 58: 20–28.
Offman EM, Freeman DJ, Dresser GK, et al. Red wine-cisapride interaction: comparison with grapefruit juice. Clin Pharmacol Ther 2001; 70 (1): 17–23.
Chan WK, Nguyen LT, Miller VP, et al. Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine. Life Sci 1998;62: 135–142.
F Peter Guengerich. Cytochrome P450 enzymes in the generation of commercial products. Nature Rev Drug Disc 2002; 1 (5): 359–366.
0
浏览量
376
Downloads
1
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621