Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis

Liu Yun-fang; Zhao Yu-xia; Yu Hui-ming

doi:10.1007/BF02836516

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Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis

OriginalPaper | Updated：2021-08-27

- Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis
- Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis
- 中国结合医学杂志（英文版） 2006年12卷第3期页码：171-174
- Affiliations：
  
  1. Department of Diagnosis, School of Medicine, Shandong University,Jinan
  2. Department of Traditional Chinese Medicine, Qilu Hospital, Shandong University,China
- Author bio：
- Funds：
  
  Supported by the 9th 5-year Key Project of Shandong Provincial Ministry of Health (No. 9711)
- DOI：10.1007/BF02836516
  中图分类号：
- 纸质出版日期：2006，
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Yun-fang, L., Yu-xia, Z. & Hui-ming, Y. Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis., Chin. J. Integr. Med. 12, 171–174 (2006). https://doi.org/10.1007/BF02836516

Liu Yun-fang, Zhao Yu-xia, Yu Hui-ming. Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis[J]. Chinese Journal of Integrative Medicine, 2006,12(3):171-174.
Yun-fang, L., Yu-xia, Z. & Hui-ming, Y. Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis., Chin. J. Integr. Med. 12, 171–174 (2006). https://doi.org/10.1007/BF02836516 DOI：

Liu Yun-fang, Zhao Yu-xia, Yu Hui-ming. Effects of Quyu Xiaoban Capsule on vascular endothelial function in patients with atherosclerosis[J]. Chinese Journal of Integrative Medicine, 2006,12(3):171-174. DOI： 10.1007/BF02836516.

摘要

Objective: To evaluate the therapeutic effects of Quyu Xiaoban Capsule

(QYXBC) on endothelial dependent vascular relaxation (EDVR) function in patients with atherosclerosis (AS) with ultrasonic technique.Methods: Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated with QYXBC for 10 months.Results: Before treatment

the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower than that in the control group (P < 0.01)

while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group after treatment

with D%-R improved significantly (P < 0.01)

total cholesterol (TC)

triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) decreased by 16.3%

5.6%

10.2% respectively and high-density lipoprotein cholesterol (HDL-C) increased by 7.5%. EDVR was correlated negatively with the serum TC

LDL-C concentrations and the baseline brachial diameter (D0 (r = -0.41

-0.66

-0.59

respectively

allP < 0.01)

but correlated positively with HDL-C (r = 0.62

P < 0.05). The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations (r = 0.67

0.59

bothP < 0.01).Conclusion: QYXBC can lower the level of blood lipids and improve significantly EDVR function.

Abstract

Objective: To evaluate the therapeutic effects of Quyu Xiaoban Capsule

the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower than that in the control group (P < 0.01)

while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group after treatment

with D%-R improved significantly (P < 0.01)

total cholesterol (TC)

triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) decreased by 16.3%

5.6%

10.2% respectively and high-density lipoprotein cholesterol (HDL-C) increased by 7.5%. EDVR was correlated negatively with the serum TC

LDL-C concentrations and the baseline brachial diameter (D0 (r = -0.41

-0.66

-0.59

respectively

allP < 0.01)

but correlated positively with HDL-C (r = 0.62

P < 0.05). The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations (r = 0.67

0.59

bothP < 0.01).Conclusion: QYXBC can lower the level of blood lipids and improve significantly EDVR function.

关键词

Quyu Xiaoban Capsuleatherosclerosisendothelial function

Keywords

Quyu Xiaoban Capsuleatherosclerosisendothelial function

references

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Vogel RA, Corretti MC, Plotnick GD. Changes in flowmediated brachial artery vasoactivity with lowering of desirable cholesterol levels in healthy middle-aged men. Am J Cardiol 1996;77: 37–40.

Kool M, Lusstermans F, Kragten H, et al. Does lowering of cholesterol levels influence functional properties of large arteries? Eur J Clin Pharmacol 1995;48: 217–223.

Celermajer DS, Sorensen KE, Gooch VM, et al. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340: 1111–1115.

Zeiher AM, Drexler H, Saurbier B, et al. Endotheliummediated coronary blood flow modulation in humans: Effects of age, atherosclerosis, hypercholesterolemia and hypertension. J Clin Invest 1993;92: 652–662.

Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315: 1046 -1051.

Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulation. J Am Coll Cardiol 1995;26: 1235 -1241.

Andrews HE, Bruckdorfer KR, Dunn RC, et al. Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta. Nature 1987;327: 237–239.

Wennmalm A. Nitric oxide in the cardiovascular system: role in atherosclerosis and hypercholesterolemia. Blood Press 1994;3: 279–282.

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