Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis

Xu Feng-qin; Li Li-zhi; Xu Hao; Yao Li-fang; Chen Ke-ji; Shao Nian-fang

doi:10.1007/BF02836551

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Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis

OriginalPaper | Updated：2021-08-27

- Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis
- Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis
- 中国结合医学杂志（英文版） 2004年10卷第1期页码：14-18
- Affiliations：
  
  1. Xiyuan Hospital, China Academy of Traditional Chinese Medicine
  2. The Affiliated Hospital to Shandong University of TCM,China
- Author bio：
- Funds：
- DOI：10.1007/BF02836551
  中图分类号：
- 纸质出版日期：2004，
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Feng-qin, X., Li-zhi, L., Hao, X. et al. Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis., Chin. J. Integr. Med. 10, 14–18 (2004). https://doi.org/10.1007/BF02836551

Xu Feng-qin, Li Li-zhi, Xu Hao, et al. Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis[J]. Chinese Journal of Integrative Medicine, 2004,10(1):14-18.
Feng-qin, X., Li-zhi, L., Hao, X. et al. Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis., Chin. J. Integr. Med. 10, 14–18 (2004). https://doi.org/10.1007/BF02836551 DOI：

Xu Feng-qin, Li Li-zhi, Xu Hao, et al. Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis[J]. Chinese Journal of Integrative Medicine, 2004,10(1):14-18. DOI： 10.1007/BF02836551.

摘要

Objective:To study the effect of Xiongshao Capsule (XSC)

a TCM herb that can promote blood circulation to remove blood stasis

on the endothelial dependent relaxation function

serum nitric oxide (NO)

and plasma endothelin-KET-1) of the patients with cervical atherosclerosis.Methods: Forty patients were randomly divided into two groups: XSC group and Probucol group (western medicine control). In addition

20 healthy people were set as a normal control group. Plasma ET-1

serum NO

the internal diameter of basal brachial artery

endothelial dependent flow mediated dilation (FMD) and non-endothelial dependent nitroglycerin induced dilation (NID) to the trial group before and after therapy and to the healthy control group were determined respectively. Results: Compared to the healthy control group

FMD of patients with atherosclerosis was damaged obviously

the serum NO level decreased

plasma ET-1 increased (P< 0.01)

NID also decreased (P<0.05)

the internal diameter of basal brachial artery has no obvious difference (P>0.05). After the patients with atherosclerosis were treated with Xiongshao Capsule for 12 weeks

FMD increased evidently

plasma ET-1 decreased

serum NO and the ratio of NO/ET-1 increased

compared with the level before therapy and Probucol group

the difference was significant (P<0.05

P<0.01)

NID didn’t change obviously (P>0.05).Conclusion: XSC could regulate vascular activity factor and improve the function of endothelial dependent vascular dilation of patients with atherosclerosis.

Abstract

Objective:To study the effect of Xiongshao Capsule (XSC)

a TCM herb that can promote blood circulation to remove blood stasis

on the endothelial dependent relaxation function

serum nitric oxide (NO)

20 healthy people were set as a normal control group. Plasma ET-1

serum NO

the internal diameter of basal brachial artery

FMD of patients with atherosclerosis was damaged obviously

the serum NO level decreased

plasma ET-1 increased (P< 0.01)

NID also decreased (P<0.05)

the internal diameter of basal brachial artery has no obvious difference (P>0.05). After the patients with atherosclerosis were treated with Xiongshao Capsule for 12 weeks

FMD increased evidently

plasma ET-1 decreased

serum NO and the ratio of NO/ET-1 increased

compared with the level before therapy and Probucol group

the difference was significant (P<0.05

P<0.01)

NID didn’t change obviously (P>0.05).Conclusion: XSC could regulate vascular activity factor and improve the function of endothelial dependent vascular dilation of patients with atherosclerosis.

关键词

atherosclerosisendothelial vasodilator functionXiongshao capsule

Keywords

atherosclerosisendothelial vasodilator functionXiongshao capsule

references

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Reddy KG, Nair RN, Sheehan HM, et al. Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. J Am Coll Cardiol 1994;23(4): 833–843.

Werns SW, Walton JA, Hsia HH, et al. Evidence endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation 1989;79(2): 287–291.

Xu H, Shi DZ, Chen KJ, et al. Effect of Xiongshao Capsule on vessel remodeling of pig coronary artery after saccule was hurt. Chin J Integr Tradit West Med 2001; 21(8): 591–599.

Celermajer Ds, Sorensen KE, Bull Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and at risk of atherosclerosis. Lancet 1992; 340: 1111–1115.

Li Liang, Zhao Shuiping, Li Xiangping, et al, Non-invasive detection of endothelial dysfunction in patients with essential hypertension. Int J Cardiol 1997; 16(2): 165–169.

Liang RX, Huang LQ, Liu JF, et al. Experimental observation of Chuanxiong and Chishao on reducing blood lipoid of hyperglycemia rats, anti-oxidation and vascular endothelium function. Chin J Exper Trad Med Form 2002;8(1): 43–45.

Wang X, Han GQ, Li RZ, et al. Screening and research of modern bio-analysis on common Chinese Medicine. J Beijing Med Univ 1986; 18(1): 31–35.

Zhou SC, Zheng ZS. Early examination and treatment to dependent dysfunction of vascular endothelium. South China J Cardiovasc Dis 1998;4(1): 62–64.

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