Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis

Dong Xiang-yu; Ni Qian; Shen Yang

doi:10.1007/BF02836555

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Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis

OriginalPaper | Updated：2021-08-27

- Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis
- Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis
- 中国结合医学杂志（英文版） 2004年10卷第1期页码：29-32
- Affiliations：
  
  Paediatrics Department, The Second Affiliated Hospital of Lanzhou Medical College,Lanzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02836555
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- 纸质出版日期：2004，
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Xiang-yu, D., Qian, N. & Yang, S. Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis., Chin. J. Integr. Med. 10, 29–32 (2004). https://doi.org/10.1007/BF02836555

Dong Xiang-yu, Ni Qian, Shen Yang. Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis[J]. Chinese Journal of Integrative Medicine, 2004,10(1):29-32.
Xiang-yu, D., Qian, N. & Yang, S. Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis., Chin. J. Integr. Med. 10, 29–32 (2004). https://doi.org/10.1007/BF02836555 DOI：

Dong Xiang-yu, Ni Qian, Shen Yang. Effect of Astragalus Injection on levels of blood selenium and immunity function in children with viral myocarditis[J]. Chinese Journal of Integrative Medicine, 2004,10(1):29-32. DOI： 10.1007/BF02836555.

摘要

Objective: To observe the effect of Astragalus Injection (Al) on levels of blood selenium (Se) and cytokines

and T cellular immune function with viral myocarditis (VM) in children.Methods: Eighty children with VM were randomly divided into 2 groups. The control group consisted of 38 patients

to whom conventional therapy

including energy mixture

vitamin C and coenzyme Q10

etc. were given. The treated group (n = 42)

to whom combination therapy of conventional therapy and Al were given. The levels of blood Se and cytokine

including interleukin-1 (IL-1)

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

and also evaluation of T lymphocyte subsets and cardiac function were observed.Results: The results showed that after treatment

the levels of blood Se were significantly higher (P<0. 01)

while IL-1

IL-6 and TNF-α were significantly lower (P<0.01) than those before treatment in the control group. The left ventricular end diameter (LVED) were significantly decreased (P<0.01)

left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were significantly increased than those before treatment in the treated group(P<0.01

P<0.05). T lymphocyte subsets got normalized (P<0.01)

and compared with the control group

the difference was significant (P<0.01).Conclusion: Astragalus membranaceus possesses anti-viral effect

adjusts the balance of cytokine and T cellular immunity

and improves the clinical manifestation and cardiac function. It is an effective approach in treating viral myocarditis.

Abstract

Objective: To observe the effect of Astragalus Injection (Al) on levels of blood selenium (Se) and cytokines

and T cellular immune function with viral myocarditis (VM) in children.Methods: Eighty children with VM were randomly divided into 2 groups. The control group consisted of 38 patients

to whom conventional therapy

including energy mixture

vitamin C and coenzyme Q10

etc. were given. The treated group (n = 42)

to whom combination therapy of conventional therapy and Al were given. The levels of blood Se and cytokine

including interleukin-1 (IL-1)

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

and also evaluation of T lymphocyte subsets and cardiac function were observed.Results: The results showed that after treatment

the levels of blood Se were significantly higher (P<0. 01)

while IL-1

IL-6 and TNF-α were significantly lower (P<0.01) than those before treatment in the control group. The left ventricular end diameter (LVED) were significantly decreased (P<0.01)

left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were significantly increased than those before treatment in the treated group(P<0.01

P<0.05). T lymphocyte subsets got normalized (P<0.01)

and compared with the control group

the difference was significant (P<0.01).Conclusion: Astragalus membranaceus possesses anti-viral effect

adjusts the balance of cytokine and T cellular immunity

and improves the clinical manifestation and cardiac function. It is an effective approach in treating viral myocarditis.

关键词

Astragalus InjectionViral Myocarditisseleniumimmunity

Keywords

Astragalus InjectionViral Myocarditisseleniumimmunity

references

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Mann DL. Interleukin-6 and viral myocarditis: the Yin-Yang of cardiac innate immune responses. J Mol Cell Cardiol 2001;33(9): 1551–1553.

Zeng S, Zhou T, He Z, et al. Influence of intravenousimmunoglobulin on T lymphocyte subsets, NK cell and some cytokines in mice with experimental viral myocarditis. J West China Med College 1999;30(3): 289–292.

Liu GX, Yang YZ, Gu QB. The efficacy of Astragalus membranaceus on L-calcium passage of myocardial cell in virus infected rats. Chin J Integr Tradit West Med 1998; (Suppl): 49–51.

The Project of Co-ordinating Group of State “95” Plan of Dealing with Key Problem in Science and Technology. The medical therapy of acute viral myocarditis. Chin J Cardiov Dis 1999;27(6): 413–415.

Zhang XL, Yuan XD. Qidong Yixin oral liquid in treating 30 cases of viral myocarditis in children. Chin J Integr Tradit West Med 1999;19(6): 339.

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