Effects of Shenqi Fuzheng injection on changes of matrix metalloproteinases in patients with acute myocardial infarction

Hao Yu-ming

doi:10.1007/BF02836556

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Effects of Shenqi Fuzheng injection on changes of matrix metalloproteinases in patients with acute myocardial infarction

OriginalPaper | Updated：2021-08-27

- Effects of Shenqi Fuzheng injection on changes of matrix metalloproteinases in patients with acute myocardial infarction
- Effects of Shenqi Fuzheng injection on changes of matrix metalloproteinases in patients with acute myocardial infarction
- 中国结合医学杂志（英文版） 2004年10卷第1期页码：33-35
- Affiliations：
  
  The Second Hospital of Hebei Medical University,Shijiazhuang
- Author bio：
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- DOI：10.1007/BF02836556
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- 纸质出版日期：2004，
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Yu-ming, H. Effects of Shenqi Fuzheng injection on changes of matrix metalloproteinases in patients with acute myocardial infarction., Chin. J. Integr. Med. 10, 33–35 (2004). https://doi.org/10.1007/BF02836556

Hao Yu-ming. Effects of Shenqi Fuzheng injection on changes of matrix metalloproteinases in patients with acute myocardial infarction[J]. Chinese Journal of Integrative Medicine, 2004,10(1):33-35.
Yu-ming, H. Effects of Shenqi Fuzheng injection on changes of matrix metalloproteinases in patients with acute myocardial infarction., Chin. J. Integr. Med. 10, 33–35 (2004). https://doi.org/10.1007/BF02836556 DOI：

Hao Yu-ming. Effects of Shenqi Fuzheng injection on changes of matrix metalloproteinases in patients with acute myocardial infarction[J]. Chinese Journal of Integrative Medicine, 2004,10(1):33-35. DOI： 10.1007/BF02836556.

摘要

Objective: To investigate the effects of Shenqi Fuzheng injection SQFZI) on ventricular remodeling (VR) after acute myocardial infarction (AMI).Methods: Sixty patients with AMI were randomly divided into two groups and received conventional therapy and conventional therapy plus SQFZI separately. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-9 (TIMP-9) in plasma was measured on the 1st and 14th days after AMI.Results:MMP-9 andMMP-9/TIMP-9 were increased after AMI

after 2-week treatment

the level ofMMP-9 andMMP-9/TIMP-9 decreased more significantly in SQFZI group than that in the conventional group (P<0.05).Conclusion; Early treatment with SQFZI after AMI could reduce the level of MMPs and the production of collagen. It may be useful for the prevention of VR and heart failure after AMI.

Abstract

after 2-week treatment

关键词

matrix metalloproteinaseacute myocardial infarctionventricular remodelingShenqi Fuzheng injection

Keywords

matrix metalloproteinaseacute myocardial infarctionventricular remodelingShenqi Fuzheng injection

references

Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction: experimental observation and clinical implication. Circulation 1990;81: 1161–1172.

Host NB, Jensen LT, Bendixen PM, et al. The aminoterminal propeptide of type HI procollagen provides new information on prognosis after acute myocardial infarction. Am J Cardiol 1995;76: 869–873.

Modena MG. Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction. Am Heart J 2001; 141: 41–46.

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