Effects of ligustrazine on myocardial fibrosis in rats with pressure overload

Ren Hai-ling; Jiang Shi-sen; Xie Du-jiang; Wang Chun-hui; Hang Tao

doi:10.1007/BF02836560

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Effects of ligustrazine on myocardial fibrosis in rats with pressure overload

OriginalPaper | Updated：2021-08-27

- Effects of ligustrazine on myocardial fibrosis in rats with pressure overload
- Effects of ligustrazine on myocardial fibrosis in rats with pressure overload
- 中国结合医学杂志（英文版） 2004年10卷第1期页码：44-47
- Affiliations：
  
  Department of Cardiology, Jinling Hospital,Nanjing
- Author bio：
- Funds：
- DOI：10.1007/BF02836560
  中图分类号：
- 纸质出版日期：2004，
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Hai-ling, R., Shi-sen, J., Du-jiang, X. et al. Effects of ligustrazine on myocardial fibrosis in rats with pressure overload., Chin. J. Integr. Med. 10, 44–47 (2004). https://doi.org/10.1007/BF02836560

Ren Hai-ling, Jiang Shi-sen, Xie Du-jiang, et al. Effects of ligustrazine on myocardial fibrosis in rats with pressure overload[J]. Chinese Journal of Integrative Medicine, 2004,10(1):44-47.
Hai-ling, R., Shi-sen, J., Du-jiang, X. et al. Effects of ligustrazine on myocardial fibrosis in rats with pressure overload., Chin. J. Integr. Med. 10, 44–47 (2004). https://doi.org/10.1007/BF02836560 DOI：

Ren Hai-ling, Jiang Shi-sen, Xie Du-jiang, et al. Effects of ligustrazine on myocardial fibrosis in rats with pressure overload[J]. Chinese Journal of Integrative Medicine, 2004,10(1):44-47. DOI： 10.1007/BF02836560.

摘要

Objective: To investigate the effects of ligustrazine (Li) on myocardial fibrosis in rats with pressure overload.Methods: Pressure overload rat models were established by constricting the abdominal aorta. Sixty-three SD rats were divided into 3 groups: Sham operated group (SOG

n = 21)

operated group (OG

n = 21) and operated combined with ligustrazine group (OG+Li

n = 21). Each group was randomly assigned to seven time points: The 1st

2nd

4th

7th

14th

21st and 30th day after operation. Three rats were included in each time point. Serial sections of cardiac tissues were examined and the morphological or morphometric analysis of the SOG

OG and OG+Li done by histopathological and computer image analyzer technique.Results: (1) It showed that there were reactive fibrosis (from the 4th day on after operation) and reparative fibrosis (from the 21st day on after operation) in the OG

while myocardial fibrosis in the OG+Li was alleviated. Though reactive fibrosis (from the 21st day on after operation) was shown

reparative fibrosis wasn’t seen. (2) Perivascular collagen area (PVCA) in the OG (2. 09 ± 0. 45) was significantly higher than SOG (0.83 ± 0.06) from the 1st day on after operation and then steadily increased

while in the OG+Li (1.16 ± 0.06)

it was significantly lower than OG at the same time; collagen volume fraction (CVF) in the OG (3.08 ± 0. 56) significantly increased compared with the SOG (2. 78 ± 0. 64) from the 2nd day on after operation and showed a trend of rapid ascending from the 21st day on after operation; and in the OG + Li (4.69 ± 0.85)

it was significantly decreased compared with the OG (7.56 ± 0.88) from the 21st day on after operation

with allP<0. 05.Conclusion: Ligustrazine could alleviate and postpone the accumulation of myocardial collagen and has protective effects on the heart.

Abstract

n = 21)

operated group (OG

n = 21) and operated combined with ligustrazine group (OG+Li

n = 21). Each group was randomly assigned to seven time points: The 1st

2nd

4th

7th

14th

21st and 30th day after operation. Three rats were included in each time point. Serial sections of cardiac tissues were examined and the morphological or morphometric analysis of the SOG

while myocardial fibrosis in the OG+Li was alleviated. Though reactive fibrosis (from the 21st day on after operation) was shown

while in the OG+Li (1.16 ± 0.06)

it was significantly decreased compared with the OG (7.56 ± 0.88) from the 21st day on after operation

with allP<0. 05.Conclusion: Ligustrazine could alleviate and postpone the accumulation of myocardial collagen and has protective effects on the heart.

关键词

Ligustrazinepressure overloadmyocardial fibrosis

Keywords

Ligustrazinepressure overloadmyocardial fibrosis

references

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Shang QX, Zhang DS, Guan WX, et al. The influence of Salvia miltiorrhiza and tetramethylpyrazine on DNA content of cicatricial fibroblasts and its cellular cycle. Chin J Reparat Reconstr Surg 1998;12(6): 326–327.

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