Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy

Chen Hong; Dong Yang-shen; Chen Fen-hua; Ji Jing-zhi; Chen Yan-feng; Yikura Y.; Kozo Ueno

doi:10.1007/BF02836564

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Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy

OriginalPaper | Updated：2021-08-27

- Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy
- Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy
- 中国结合医学杂志（英文版） 2004年10卷第1期页码：55-58
- Affiliations：
  
  1. Department of Pediatrics, The Third Hospital Affiliated to Sun Yat-Sen University of Medical Sciences,Guangzhou
  2. Department of Pediatrics, Showa University School of Medicine,Tokyo,Japan
- Author bio：
- Funds：
- DOI：10.1007/BF02836564
  中图分类号：
- 纸质出版日期：2004，
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Hong, C., Yang-shen, D., Fen-hua, C. et al. Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy., Chin. J. Integr. Med. 10, 55 (2004). https://doi.org/10.1007/BF02836564

Chen Hong, Dong Yang-shen, Chen Fen-hua, et al. Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy[J]. Chinese Journal of Integrative Medicine, 2004,10(1):55-58.
Hong, C., Yang-shen, D., Fen-hua, C. et al. Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy., Chin. J. Integr. Med. 10, 55 (2004). https://doi.org/10.1007/BF02836564 DOI：

Chen Hong, Dong Yang-shen, Chen Fen-hua, et al. Effect of Buzhong Yiqi decoction on murine liver damage induced by food allergy[J]. Chinese Journal of Integrative Medicine, 2004,10(1):55-58. DOI： 10.1007/BF02836564.

摘要

Objective: To investigate the effect of Buzhong Yiqi decoction

BZYQD) on liver damage induced by food allergy in mice.Methods: Nc/Jic strain mice with high levels of serum IgE were sensitized by ovalbumin (OVA)

and then divided into two groups and respectively treated with BZYQD (treated group) or normal saline (model group). Samples of serum

liver tissues and small intestine were collected two weeks later

and another group of non-sensitized mice was set as the normal group. The levels of serum alanine aminotransferase (ALT) were measured with spectrophotometry. The liver tissue and small intestine were stained with hematoxylin and eosin (HE) for pathologic analysis. The liver samples were also subjected to analysis of CD4-T helper cell and cytokine (interleukin-4

IL-4

interleukin-6

IL-6) expression with immunohistochemical (avidin-biotin complex

ABC) method.Results: Serum ALT levels decreased and obvious pathologic improvements were seen in the mice treated with BZYQD. And compared with the model mice

the number of positive cells of IL-4

IL-6 and CD4 cell decreased significantly in those treated with BZYQD.Conclusion: BZYQD can effectively decrease the production of cytokines associated with allergic reaction in the liver of mice thus effective in treating liver damage caused by food allergy.

Abstract

Objective: To investigate the effect of Buzhong Yiqi decoction

BZYQD) on liver damage induced by food allergy in mice.Methods: Nc/Jic strain mice with high levels of serum IgE were sensitized by ovalbumin (OVA)

and then divided into two groups and respectively treated with BZYQD (treated group) or normal saline (model group). Samples of serum

liver tissues and small intestine were collected two weeks later

IL-4

interleukin-6

IL-6) expression with immunohistochemical (avidin-biotin complex

ABC) method.Results: Serum ALT levels decreased and obvious pathologic improvements were seen in the mice treated with BZYQD. And compared with the model mice

the number of positive cells of IL-4

关键词

food allergyLiver DamageBuzhong Yiqi decoction

Keywords

food allergyLiver DamageBuzhong Yiqi decoction

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