Relationship of tumor necrosis factor-α and nitrogen oxide with treatment of frequent relapse nephrotic syndrome by Shenkangling Granule in children

Wang Li-ling; Zheng Jian; Zeng Zhang-chao; Dong Fei-xia; Wu Qun-li

doi:10.1007/BF02838030

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Relationship of tumor necrosis factor-α and nitrogen oxide with treatment of frequent relapse nephrotic syndrome by Shenkangling Granule in children

OriginalPaper | Updated：2021-08-27

- Relationship of tumor necrosis factor-α and nitrogen oxide with treatment of frequent relapse nephrotic syndrome by Shenkangling Granule in children
- Relationship of tumor necrosis factor-α and nitrogen oxide with treatment of frequent relapse nephrotic syndrome by Shenkangling Granule in children
- 中国结合医学杂志（英文版） 2003年9卷第3期页码：191-194
- Affiliations：
  
  1. Fujian Provincial Union Hospital,Fujian
  2. Fujian Provincial People’s Hospital,China
- Author bio：
- Funds：
- DOI：10.1007/BF02838030
  中图分类号：
- 纸质出版日期：2003，
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Li-ling, W., Jian, Z., Zhang-chao, Z. et al. Relationship of tumor necrosis factor-α and nitrogen oxide with treatment of frequent relapse nephrotic syndrome by Shenkangling Granule in children., Chin. J. Integr. Med. 9, 191–194 (2003). https://doi.org/10.1007/BF02838030

Wang Li-ling, Zheng Jian, Zeng Zhang-chao, et al. Relationship of tumor necrosis factor-α and nitrogen oxide with treatment of frequent relapse nephrotic syndrome by Shenkangling Granule in children[J]. Chinese Journal of Integrative Medicine, 2003,9(3):191-194.
Li-ling, W., Jian, Z., Zhang-chao, Z. et al. Relationship of tumor necrosis factor-α and nitrogen oxide with treatment of frequent relapse nephrotic syndrome by Shenkangling Granule in children., Chin. J. Integr. Med. 9, 191–194 (2003). https://doi.org/10.1007/BF02838030 DOI：

Wang Li-ling, Zheng Jian, Zeng Zhang-chao, et al. Relationship of tumor necrosis factor-α and nitrogen oxide with treatment of frequent relapse nephrotic syndrome by Shenkangling Granule in children[J]. Chinese Journal of Integrative Medicine, 2003,9(3):191-194. DOI： 10.1007/BF02838030.

摘要

Objective: To observe the relationship of tumor necrosis factor-α (TNF-α) and nitrogen oxide (NO) with the treatment of frequent relapse nephrotic syndrome (FRNS) and to explore the pathogenesis of FRNS and the therapeutic mechanism of Shenkangling (SKL) Granule in children.Methods: Sixty children suffering from FRNS were randomly divided into the treated group and control group

30 in each

and the other 30 healthy children were taken as healthy group. The patients were treated with prednisone for a long-term course

and those with no effect or partial effect shown were treated with additional Tripterygium or Cytoxan in the control group

while in the treated group patients were treated with prednisone and additional SKL. The two groups were compared as to their changes of TNF-α

NO before and after treatment

and the relapses after treatment.Results: The levels of TNF-α and NO in the sick children before treatment were markedly higher than those after treatment and normal group (P < 0.01). The positive correlation between TNF-α of FRNS cases and relapse risk displayed more significance than that between the relapse of FRNS and NO. The difference between treated group and control group was significant (P < 0.01).Conclusion: TNF-α can be regarded as the monitoring parameter of the active phase in FRNS

and the higher the level

the more possible the relapse would occur. SKL could markedly reduce the relapse rate of FRNS in children.

Abstract

30 in each

and the other 30 healthy children were taken as healthy group. The patients were treated with prednisone for a long-term course

and those with no effect or partial effect shown were treated with additional Tripterygium or Cytoxan in the control group

while in the treated group patients were treated with prednisone and additional SKL. The two groups were compared as to their changes of TNF-α

NO before and after treatment

and the higher the level

the more possible the relapse would occur. SKL could markedly reduce the relapse rate of FRNS in children.

关键词

children primary nephrotic syndromefrequent relapsetumor necrosis factor-αnitrogen oxideShenkangling Granule

Keywords

children primary nephrotic syndromefrequent relapsetumor necrosis factor-αnitrogen oxideShenkangling Granule

references

Kidney Diseases Study Group, Pediatric Society, Chinese Medical Association. Clinical classification, diagnosis and treatment of children glomerulopathy. Chin J Pediatrics 2001; 39(12): 746–749.

FENG JM, LIU YS, WANG XD, et al. Significance of effect of TNF-α, NO in burn combined with endotoxemia early renal injury. Chin J Burn 2000; 16(2): 89–92.

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