Study on therapeutic mechanism of Neiyifang in treating endometriosis

Yu Chao-qin; Cai Zai-long; Liu Yu-huan; Wang Da-zeng; Wang Zu-qian

doi:10.1007/BF02838554

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Study on therapeutic mechanism of Neiyifang in treating endometriosis

OriginalPaper | Updated：2021-08-27

- Study on therapeutic mechanism of Neiyifang in treating endometriosis
- Study on therapeutic mechanism of Neiyifang in treating endometriosis
- 中国结合医学杂志（英文版） 2003年9卷第2期页码：88-92
- Affiliations：
  
  1. Changhai Hospital, Second Military Medical University,Shanghai
  2. Department of Biochemistry, Basic Board, Second Military Medical University,China
  3. Longhua Hospital, Shanghai TCM University,China
- Author bio：
- Funds：
  
  This item was supported by National Funds of Natural Sciences(No. 30070942)
- DOI：10.1007/BF02838554
  中图分类号：
- 纸质出版日期：2003，
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Chao-qin, Y., Zai-long, C., Yu-huan, L. et al. Study on therapeutic mechanism of Neiyifang in treating endometriosis., Chin. J. Integr. Med. 9, 88–92 (2003). https://doi.org/10.1007/BF02838554

Yu Chao-qin, Cai Zai-long, Liu Yu-huan, et al. Study on therapeutic mechanism of Neiyifang in treating endometriosis[J]. Chinese Journal of Integrative Medicine, 2003,9(2):88-92.
Chao-qin, Y., Zai-long, C., Yu-huan, L. et al. Study on therapeutic mechanism of Neiyifang in treating endometriosis., Chin. J. Integr. Med. 9, 88–92 (2003). https://doi.org/10.1007/BF02838554 DOI：

Yu Chao-qin, Cai Zai-long, Liu Yu-huan, et al. Study on therapeutic mechanism of Neiyifang in treating endometriosis[J]. Chinese Journal of Integrative Medicine, 2003,9(2):88-92. DOI： 10.1007/BF02838554.

摘要

Objective: To observe the clinical effect of Neiyifang (NYF) in treating endometriosis and to explore its therapeutic mechanism through observing its influence on plasma β-endorphin (β-EP) in different menstrual stages and levels of prostaglandins (PGs) in menstruation.Methods:NYF was administered to 104 patients with endometriosis one dose daily with 3 successive menstrual cycles as one therapeutic course. Peripheral blood β-EP level in follicular

luteal and menstrual stages

as well as PGF2α

PGE2

thromboxane B2 and 6-keto-PGFl α levels in menstrual stage were detected by RIA

and controlled with those in 15 healthy persons.Results: (1) The total effective rate of NYF was 81.3% and it showed significant effect in improving patients’ clinical symptoms and physical signs; (2) In menstrual stage

the levels of β-EP

6-keto-PGFα/ TXB2 were lower(P <0.05) and levels of PGF2α

PGE2

TXB2 and 6-keto-PGF1α were higher (P< 0. 05) in patients than those in control

and the higher the level of PGE2

the severer the menalgia

(3) NYF could increase levels of β-EP

6-keto-PGF1α

and reduce levels of PGF2α

PGE2α in menstrual stage of patients (all P<0.05).Conclusion: (1) NYF has good clinical effect in treating endometriosis; (2) Patients’ symptom of menalgia is closely related with the excessive high levels of PGF2α and PGE2

PGI2/TXA2 ratio disturbance

and excessive low level of β-EP; (3) NYF could significantly decrease the PGE2

PGF1α levels

increase the 6-keto-PGF1α/TXB2 ratio and the level of β-EP

so as to alleviate the menalgia in patients with endometriosis.

Abstract

luteal and menstrual stages

as well as PGF2α

PGE2

thromboxane B2 and 6-keto-PGFl α levels in menstrual stage were detected by RIA

the levels of β-EP

6-keto-PGFα/ TXB2 were lower(P <0.05) and levels of PGF2α

PGE2

TXB2 and 6-keto-PGF1α were higher (P< 0. 05) in patients than those in control

and the higher the level of PGE2

the severer the menalgia

(3) NYF could increase levels of β-EP

6-keto-PGF1α

and reduce levels of PGF2α

PGI2/TXA2 ratio disturbance

and excessive low level of β-EP; (3) NYF could significantly decrease the PGE2

PGF1α levels

increase the 6-keto-PGF1α/TXB2 ratio and the level of β-EP

so as to alleviate the menalgia in patients with endometriosis.

关键词

endometriosisprostaglandinβ-endorphinNeiyifang

Keywords

endometriosisprostaglandinβ-endorphinNeiyifang

references

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Strathy JH, MolgaardCA, Coulam CB, et al. Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril 1982; 38: 667–672.

Andersch B, Milson I. An epidemiological study of young women with dysmenorrhea. Am J Obstet Gynecol 1982; 144: 655.

Third Academic Conference of Special Committee of Obstetrics and Gynecology, Chinese Association of the Integration of Traditional and Western Medicine. Standard for diagnosis and treatment of endometriosis, pregnant hypertension syndrome and female infertility by integrated traditional Chinese and western medicine (draft). CJIM (Chin) 1991; 11(6): 376.

LI JJ. β-endorphin in field of obstetrics and gynecology. Pract J Obstet & Gynecol 1990;6(3): 155.

Nagamasa M, Chiaki L, Yorito Y, et al. Increased killer inhibitory receptor KIR2DL1 expression among natural killer cells in women with pelvic endometriosis. Fertil Steril 2002; 77(2): 297–302.

Nataraj C, Thomas DW, Tilley SL, et al. Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse. J Clin Invest 2001; 108(8): 1229–1235.

Scandella E, Ying Men, Gillessen S, et al. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-dirived dendritic cells. Blood 2002; 100 (4): 1354–1361.

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