Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury

Wang Xiang-rui; Yu Qin-yan; Yan Jun; Sun Da-jin

doi:10.1007/BF02838566

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Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury

OriginalPaper | Updated：2021-08-27

- Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury
- Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury
- 中国结合医学杂志（英文版） 2003年9卷第2期页码：124-127
- Affiliations：
  
  Renji Hospital Affiliated to Shanghai Second Medical University,Shanghai
- Author bio：
- Funds：
  
  This article was supported by the National Funds of Natural Sciences (No. 39670898) and Funds from Ministry of Health(No. 98-2-314)
- DOI：10.1007/BF02838566
  中图分类号：
- 纸质出版日期：2003，
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Xiang-rui, W., Qin-yan, Y., Jun, Y. et al. Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury., Chin. J. Integr. Med. 9, 124–127 (2003). https://doi.org/10.1007/BF02838566

Wang Xiang-rui, Yu Qin-yan, Yan Jun, et al. Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury[J]. Chinese Journal of Integrative Medicine, 2003,9(2):124-127.
Xiang-rui, W., Qin-yan, Y., Jun, Y. et al. Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury., Chin. J. Integr. Med. 9, 124–127 (2003). https://doi.org/10.1007/BF02838566 DOI：

Wang Xiang-rui, Yu Qin-yan, Yan Jun, et al. Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury[J]. Chinese Journal of Integrative Medicine, 2003,9(2):124-127. DOI： 10.1007/BF02838566.

摘要

Objective: To investigate the effects of electroacupuncture and ischemic preconditioning (IPC) on circulatory function in pigs with myocardial ischemia/reperfusion injury.Method: Eighteen pigs with myocardial ischemia/reperfusion injury were randomly allocated into three groups

6 in each. Group I was the control group

group II was the group that received IPC

and group III was that received both electroacupuncture and IPC Blood malondialdehyde (MDA)

Superoxide dismutase (SOD)

creatine phosphokinase (CPK) and its isoenzyme (CK-MB)

coronary artery flow and myocardial heat-shock protein (HSP) mRNA expression were detected for evaluation.Results: After treatment

the MDA content was decreased and SOD activities increased significantly in the acupuncture and IPC group compared with the control group (P<0.05 respectively). The levels of CPK

CK-MB at 20

60 min after reperfusion were significantly higher than those before treatment

but the levels in group III and group II were remarkably lower than those in group I. HSP70 mRNA expression was found to be increased in group II and group III at 60 min after ischemia/reperfusion compared with those in group I.Conclusion: Electroacupuncture can enhance the myocardial protection of IPC against ischemia/reperfusion injury. The. protective mechanism may be related to the improvement of antioxidation and the increased expression of HSP70 gene.

Abstract

6 in each. Group I was the control group

group II was the group that received IPC

and group III was that received both electroacupuncture and IPC Blood malondialdehyde (MDA)

Superoxide dismutase (SOD)

creatine phosphokinase (CPK) and its isoenzyme (CK-MB)

coronary artery flow and myocardial heat-shock protein (HSP) mRNA expression were detected for evaluation.Results: After treatment

the MDA content was decreased and SOD activities increased significantly in the acupuncture and IPC group compared with the control group (P<0.05 respectively). The levels of CPK

CK-MB at 20

60 min after reperfusion were significantly higher than those before treatment

关键词

electroacupunctureischemia/reperfusion injuryischemic preconditioningmalondialdehydesuperoxide dismutase

Keywords

electroacupunctureischemia/reperfusion injuryischemic preconditioningmalondialdehydesuperoxide dismutase

references

Murry CE, Jennings RB, Reimer KA, Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74(5): 1124–1136.

WANG XR, HANG YN, SUN DJ, et al. Observation on effect of acupuncture on cardiac function in patients undergoing heart operation. Shanghai J of Acupuncture and Moxibustion 1999; 18(5): 6–9.

Gideon C, Toshzumi S, Ricard D, et al. Optimal myocardial preconditioning in human model of ischemia and reperfusion. Circulation 1998; 98(19): II 185–190.

Del Mastro RF. An approach to free radical in medicine and biology. Acta Physiol Scand 1980;492(supp): 153–168.

Baler R, Dahl G, Voellmy R. Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSFl. Mol Cell Biol 1993;13(10): 2486–2492.

WANG XR, YU QY, SUN DJ, et al. The modulation of myocardia ischemia with electroacupuncture in patients undergoing cardiac operation. Chinese Acupuncture & Moxibustion 2000; 20(5): 261–264.

Yellon DM, Pasini E, Cargnoni A, et al. The protector role of heat stress in the ischemic and reperfused rabbit myocardium. J Mol Cell Cardiol 1992; 24(3): 895–902.

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