Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia

Liang Hui; Chen Hu; Gao Yin; Cai Ding-fang

doi:10.1007/BF02838617

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Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia

OriginalPaper | Updated：2021-08-27

- Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia
- Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia
- 中国结合医学杂志（英文版） 2003年9卷第4期页码：285-288
- Affiliations：
  
  Department of Integrated TCM and Western Medicine, Huashan Hospital, Fudan University,Shanghai
- Author bio：
- Funds：
  
  This study was supported by the fund of “Hundred Persons Project” of Shanghai Public Health Bureau (No. 97BR016)
- DOI：10.1007/BF02838617
  中图分类号：
- 纸质出版日期：2003，
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Hui, L., Hu, C., Yin, G. et al. Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia., Chin. J. Integr. Med. 9, 285–288 (2003). https://doi.org/10.1007/BF02838617

Liang Hui, Chen Hu, Gao Yin, et al. Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia[J]. Chinese Journal of Integrative Medicine, 2003,9(4):285-288.
Hui, L., Hu, C., Yin, G. et al. Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia., Chin. J. Integr. Med. 9, 285–288 (2003). https://doi.org/10.1007/BF02838617 DOI：

Liang Hui, Chen Hu, Gao Yin, et al. Effect of muscone on neuronal glutamate transporter EAAC1 expression in rats with acute cerebral ischemia[J]. Chinese Journal of Integrative Medicine, 2003,9(4):285-288. DOI： 10.1007/BF02838617.

摘要

Objective: To investigate muscone’s neuroprotective action and its mechanism in rats with acute cerebral ischemic injury.Methods: Rat focal ischemic model of middle cerebral artery occlusion (MCAO) was established by thread inserting method. TTC staining

RT-PCR and Western blot analysis were used to study the effects of muscone on infracted volume

EAAClmRNA and protein levels.Results: Infarcted volume in the muscone treated group was significantly lower than that in the model control group. Compared with normal group

EAAC1 mRNA level increased in the model control group at 6 and 24 hrs

and protein level increased at 24 hrs after modelling

muscone could reduce the increased expression in model rats.Conclusion: Muscone possesses the action of neuroprotection

its mechanism may be related to reduction of EAAC1 and protein expressions.

Abstract

RT-PCR and Western blot analysis were used to study the effects of muscone on infracted volume

EAAClmRNA and protein levels.Results: Infarcted volume in the muscone treated group was significantly lower than that in the model control group. Compared with normal group

EAAC1 mRNA level increased in the model control group at 6 and 24 hrs

and protein level increased at 24 hrs after modelling

muscone could reduce the increased expression in model rats.Conclusion: Muscone possesses the action of neuroprotection

its mechanism may be related to reduction of EAAC1 and protein expressions.

关键词

musconeCerebral Ischemianeuronal glutamate transporterneuroprotection

Keywords

musconeCerebral Ischemianeuronal glutamate transporterneuroprotection

references

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