Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus

Shen Lan; Lu Fu-er

doi:10.1007/BF02838618

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Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus

OriginalPaper | Updated：2021-08-27

- Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus
- Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus
- 中国结合医学杂志（英文版） 2003年9卷第4期页码：289-292
- Affiliations：
  
  Institute of Integrated Traditional & Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology,Wuhan
- Author bio：
- Funds：
  
  Financially supported by Education Ministry of China (Grant No. 1998–679)
- DOI：10.1007/BF02838618
  中图分类号：
- 纸质出版日期：2003，
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Lan, S., Fu-er, L. Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus., Chin. J. Integr. Med. 9, 289–292 (2003). https://doi.org/10.1007/BF02838618

Shen Lan, Lu Fu-er. Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus[J]. Chinese Journal of Integrative Medicine, 2003,9(4):289-292.
Lan, S., Fu-er, L. Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus., Chin. J. Integr. Med. 9, 289–292 (2003). https://doi.org/10.1007/BF02838618 DOI：

Shen Lan, Lu Fu-er. Effects of Portulaca oleracea on insulin resistance in rats with type 2 diabetes mellitus[J]. Chinese Journal of Integrative Medicine, 2003,9(4):289-292. DOI： 10.1007/BF02838618.

摘要

Objective: To study the effects of Portulaca oleracea

a Chinese medicinal herb

on insulin resistance in rats with type 2 diabetes mellitus (T2DM).Methods: Experimental model of T2DM was established by injection of streptozotocin (25mg/kg) and feeding with high calorie forage. The effects of Portulaca oleracea on oral glucose tolerance

serum levels of insulin

triglyceride

total cholesterol

highdensity lipoproteins-cholesterol and free fatty acids

and insulin sensitivity index were all observed.Results: Portulaca oleracea could reduce the body weight

improve the impaired glucose tolerance and lipid metabolism

decrease serum free fatty acids

attenuate hyperinsulinemia and elevate insulin sensitivity.Conclusion: Portulaca oleracea could improve insulin resistance in rats with T2DM

and the mechanism might be related to its actions in improving lipid metabolism and decreasing free fatty acids.

Abstract

Objective: To study the effects of Portulaca oleracea

a Chinese medicinal herb

serum levels of insulin

triglyceride

total cholesterol

highdensity lipoproteins-cholesterol and free fatty acids

and insulin sensitivity index were all observed.Results: Portulaca oleracea could reduce the body weight

improve the impaired glucose tolerance and lipid metabolism

decrease serum free fatty acids

attenuate hyperinsulinemia and elevate insulin sensitivity.Conclusion: Portulaca oleracea could improve insulin resistance in rats with T2DM

and the mechanism might be related to its actions in improving lipid metabolism and decreasing free fatty acids.

关键词

diabetes mellitus type 2Portulaca oleraceainsulin resistancelipid metabolismfree fatty acid

Keywords

diabetes mellitus type 2Portulaca oleraceainsulin resistancelipid metabolismfree fatty acid

references

WANG H. Treatment of diabetes mellitus with single Chinese medicinal herb Portulaca oleracea. Zhejiang J TCM 1990;25(11) ’ 516.

HE SW, LIU TM, YOU M, et al. Preventive and therapeutic effect of Portulaca oleracea on experimental hyperlipidemia in rabbits. Chinese Tradit and Herbal Drugs 1997;28(4): 221–223.

HE SW, FAN ZT, LI PX, et al. Experimental studies on anti-atherosclerosis effect of wild Portulaca oleracea. Acta Nutrimenta Sinica 1997; 19(6): 59–63.

LIU YY, MAO L, MO QZ. An experimental NIDDM rat model. Chin J Endocrinology and Metabolism 1990;6 (2): 115–116.

LI GW, PAN XR, Lilliojas, et al. A new insulin-sensitivity index for the population-based study. Chin J Internal Medicine 1993;32(10): 656–660.

Simopoulos A P Purslane. A terrestrial source of omega-3 fatty acids. New Engl J Med 1986; 315(13): 833.

Storlien LH, Jenkins AB, Chisholm DJ, et al. Influence of dietary fat composition on development of insulin resistance in rats. Diabetes 1991;40: 280–289.

ZHOU Y, ZHANG DH. Portulaca oleracea and ω-3 multivalent unsaturated fatty acids. World Notes on Plant Medicine 1995;10(6): 247–250.

Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997; 46: 3–10.

Griffin ME, Marcucci MJ, Cline GW, et al. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade. Diabetes 1999;48(6): 1270–1274.

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