Effects of choleretics on bile compositions drained from patients with pigment gallstone

Sun Bai-jun; Cui Nai-qiang; Li Dong-hua; Wang Qian

doi:10.1007/BF02857354

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Effects of choleretics on bile compositions drained from patients with pigment gallstone

OriginalPaper | Updated：2021-08-27

- Effects of choleretics on bile compositions drained from patients with pigment gallstone
- Effects of choleretics on bile compositions drained from patients with pigment gallstone
- 中国结合医学杂志（英文版） 2006年12卷第2期页码：101-106
- Affiliations：
  
  Nankai Hospital, Biliopancreatic Disease Center,Tianjin
- Author bio：
- Funds：
- DOI：10.1007/BF02857354
  中图分类号：
- 纸质出版日期：2006，
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Bai-jun, S., Nai-qiang, C., Dong-hua, L. et al. Effects of choleretics on bile compositions drained from patients with pigment gallstone., Chin. J. Integr. Med. 12, 101–106 (2006). https://doi.org/10.1007/BF02857354

Sun Bai-jun, Cui Nai-qiang, Li Dong-hua, et al. Effects of choleretics on bile compositions drained from patients with pigment gallstone[J]. Chinese Journal of Integrative Medicine, 2006,12(2):101-106.
Bai-jun, S., Nai-qiang, C., Dong-hua, L. et al. Effects of choleretics on bile compositions drained from patients with pigment gallstone., Chin. J. Integr. Med. 12, 101–106 (2006). https://doi.org/10.1007/BF02857354 DOI：

Sun Bai-jun, Cui Nai-qiang, Li Dong-hua, et al. Effects of choleretics on bile compositions drained from patients with pigment gallstone[J]. Chinese Journal of Integrative Medicine, 2006,12(2):101-106. DOI： 10.1007/BF02857354.

摘要

Objective: To provide evidence for three-level prevention of cholelithiasis by means of observing the effects of some choleretics on bile compositions drained from patients with pigment gallstone.Methods: Twenty-seven patients suffering from primary pigment gallstones and having received treatment of choledochostomies plus T-tube or endoscopic nasal bile drainage (ENBD) were divided equally into three groups

and administered respectively with Lidanling (the LDL group)

ursodesoxycholic acid (the UDA group) and combination of LDL and UDA (the LDL + UDA group) through oral intake(7 patients in each group). Besides

6 post-operational patients got no treatment with any drug were allocated in the control group. Bile of all the patients was collected before treatment and on the 1

7th day after the treatment started to detect levels of total bile acid (TBA)

glycocholic acid (GCA)

taurocholic acid (TCA)

glycocholic cheno-desoxycholic acid (GCDCA)

total bilirubin (TBIL)

uncombined bilirubin (UCB)

concentration of calcium ion (Ca2+) as well as the bacterio-genetic and endogenous β-glucuronidase activity for comparing.Results: Levels of TBA

GCA

TCA and GCDCA got gradually increased in the UDA group and the LDL + UDA group after treatment (P< 0.05)

while those in the LDL group remained unchanged

showing an insignificant difference as compared with those in the control group. In the LDL group and the LDL + UDA group

TBIL gradually increased while UCB gradually decreased in the course of treatment (P< 0.05). Moreover

levels of Ca2+ and endogenous β-glucuronidase activity got significantly lowered (P< 0.05).Conclusion: Combined use of LDL and UDA could elevate levels of TBA

GCA

TCA

GCDCA

enhance the excretion of TBIL in patients with pigment gallstone after bile drainage

lower levels of UCB and Ca2+ and the activity of endogenous β-glucuronidase in the bile

so as to reduce the possibility of stone formation of bile

and therefore

it could be used to prevent the production of pigment gallstone

especially to prevent post-operative recurrence of stones.

Abstract

and administered respectively with Lidanling (the LDL group)

ursodesoxycholic acid (the UDA group) and combination of LDL and UDA (the LDL + UDA group) through oral intake(7 patients in each group). Besides

6 post-operational patients got no treatment with any drug were allocated in the control group. Bile of all the patients was collected before treatment and on the 1

7th day after the treatment started to detect levels of total bile acid (TBA)

glycocholic acid (GCA)

taurocholic acid (TCA)

glycocholic cheno-desoxycholic acid (GCDCA)

total bilirubin (TBIL)

uncombined bilirubin (UCB)

concentration of calcium ion (Ca2+) as well as the bacterio-genetic and endogenous β-glucuronidase activity for comparing.Results: Levels of TBA

GCA

TCA and GCDCA got gradually increased in the UDA group and the LDL + UDA group after treatment (P< 0.05)

while those in the LDL group remained unchanged

showing an insignificant difference as compared with those in the control group. In the LDL group and the LDL + UDA group

TBIL gradually increased while UCB gradually decreased in the course of treatment (P< 0.05). Moreover

levels of Ca2+ and endogenous β-glucuronidase activity got significantly lowered (P< 0.05).Conclusion: Combined use of LDL and UDA could elevate levels of TBA

GCA

TCA

GCDCA

enhance the excretion of TBIL in patients with pigment gallstone after bile drainage

lower levels of UCB and Ca2+ and the activity of endogenous β-glucuronidase in the bile

so as to reduce the possibility of stone formation of bile

and therefore

it could be used to prevent the production of pigment gallstone

especially to prevent post-operative recurrence of stones.

关键词

Lidanlingpigment gallstonebile composition

Keywords

Lidanlingpigment gallstonebile composition

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