Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer

Zheng Shun-li; Yang Qing-sheng; Ma Xiao-hong

doi:10.1007/BF02857357

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Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer

OriginalPaper | Updated：2021-08-27

- Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer
- Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer
- 中国结合医学杂志（英文版） 2006年12卷第2期页码：118-121
- Affiliations：
  
  Department of Cardiothoracic Surgery, the First Affiliated Hospital of Jinan University,Guangzhou
- Author bio：
- Funds：
- DOI：10.1007/BF02857357
  中图分类号：
- 纸质出版日期：2006，
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Shun-li, Z., Qing-sheng, Y. & Xiao-hong, M. Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer., Chin. J. Integr. Med. 12, 118–121 (2006). https://doi.org/10.1007/BF02857357

Zheng Shun-li, Yang Qing-sheng, Ma Xiao-hong. Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer[J]. Chinese Journal of Integrative Medicine, 2006,12(2):118-121.
Shun-li, Z., Qing-sheng, Y. & Xiao-hong, M. Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer., Chin. J. Integr. Med. 12, 118–121 (2006). https://doi.org/10.1007/BF02857357 DOI：

Zheng Shun-li, Yang Qing-sheng, Ma Xiao-hong. Effect of Wuye Decoction on lymphocyte phenotype in patients with non-small cell lung cancer[J]. Chinese Journal of Integrative Medicine, 2006,12(2):118-121. DOI： 10.1007/BF02857357.

摘要

Objective: To investigate the effect of Chinese recipe

Wuye Decoction (WYD)

on immune function in patients with non-small cell lung cancer (NSCLC).Methods: Eighty-two patients of NSCLC with pathologically confirmed diagnosis

who had received operative treatment and completed the post-operational chemotherapy

were randomly assigned into 2 groups. Group A (42 cases) received WYD and Group B (40 cases) received no specific medicine. Positive rate of various peripheral lymphocyte subsets

including CD3

CD4

CD8

CD16

CD19 and CD25

in both groups was observed immediately after chemotherapy (T0) and 3 months later (T1)

the same indexes of 20 healthy volunteers allocated in Group C were also determined at T0 for control.Results: The positive rates of CD4

CD4/CD8

CD16

CD19 and CD25 were significantly lower (P< 0.05) while that of CD8 was significantly higher (P< 0. 05) in Group A and B at T0 than those in Group C; at T1

these indexes

except CD25

got significantly restored in Group A with the level approaching normal range (P> 0.05)

and showed significant difference from those in Group B (P< 0. 05)

since these indexes in that group remained unchanged at the corresponding period. As for CD25

it was insignificantly changed in Group A after WYD treatment

and thus

at T1

it was still lower than that in Group C (P< 0.05) and showed insignificant difference as compared with that in Group B (P>0.05). Comparison of CD3 among the 3 groups showed no significant difference (P> 0.05).Conclusion: WYD could activate the immune function of NSCLC patients

and so it is recommended to be used in the treatment of NSCLC in clinical practice.

Abstract

Objective: To investigate the effect of Chinese recipe

Wuye Decoction (WYD)

on immune function in patients with non-small cell lung cancer (NSCLC).Methods: Eighty-two patients of NSCLC with pathologically confirmed diagnosis

who had received operative treatment and completed the post-operational chemotherapy

were randomly assigned into 2 groups. Group A (42 cases) received WYD and Group B (40 cases) received no specific medicine. Positive rate of various peripheral lymphocyte subsets

including CD3

CD4

CD8

CD16

CD19 and CD25

in both groups was observed immediately after chemotherapy (T0) and 3 months later (T1)

the same indexes of 20 healthy volunteers allocated in Group C were also determined at T0 for control.Results: The positive rates of CD4

CD4/CD8

CD16

CD19 and CD25 were significantly lower (P< 0.05) while that of CD8 was significantly higher (P< 0. 05) in Group A and B at T0 than those in Group C; at T1

these indexes

except CD25

got significantly restored in Group A with the level approaching normal range (P> 0.05)

and showed significant difference from those in Group B (P< 0. 05)

since these indexes in that group remained unchanged at the corresponding period. As for CD25

it was insignificantly changed in Group A after WYD treatment

and thus

at T1

and so it is recommended to be used in the treatment of NSCLC in clinical practice.

关键词

Wuye Decoctionnon-small cell lung cancerchemotherapylymphocyte phenotype

Keywords

Wuye Decoctionnon-small cell lung cancerchemotherapylymphocyte phenotype

references

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Mountain CF. Revisions in the international system for staging lung cancer. Chest 1997; 111(6): 1710–1717.

Jiangsu New Medical College. Dictionary of materia medica. Vol 1. Shanghai: Shanghai Scientific and Technical Publishers, 1986: 555–558.

Hatakeyama N, Tamura Y, Sahara H, et al. Induction of autologus CD4 and CD8 mediated T-cell responses against acute lymphocytic leukemia cell line using apoptotic tumor cell loaded dendritic cells. Exp Hematol 2006; 34 (2): 197–207.

Schleypen JS, Baur N, Kammerer R, et al. Cytotoxic markers and frequency predict functional of natural killer cells infiltrating renal cell carcinoma. Clin Cancer Res 2006; 12(3): 718–725.

Ishigami S, Natsugoe S, Tokuda K, et al. Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer 2000; 88(3): 577–583.

Yao FX, Zheng H, Li HY, et al. Effect of chemotherapy on cellular immune function in lung cancer patients. Chin Tumor Clin Rehabil 2001; 8 (2): 53–54.

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