Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats

Liu Ke-ju; Wang Wen-jun; Li Da-jin; Jin Hui-fang; Zhou Wen-jiang

doi:10.1007/BF02857360

Your Location：

Home >

Browse articles >

Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats

OriginalPaper | Updated：2021-08-27

- Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats
- Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats
- 中国结合医学杂志（英文版） 2006年12卷第2期页码：132-136
- Affiliations：
  
  1. Obstetrics and Gynecology Hospital, Fudan University,Shanghai
  2. Radiology Institute of Fudan University,Shanghai
  3. Department of Experimental, Animal of Fudan University,Shanghai
- Author bio：
- Funds：
  
  Supported by Shanghai Funds for Gynecology of Integrated Traditional and Western Medicine (No. 96-III-001), the National Natural Science Foundation of China (No. 30472259), Shanghai Scientific Funds for Integrated Traditional and Western Medicine (No. 2004L020A).
- DOI：10.1007/BF02857360
  中图分类号：
- 纸质出版日期：2006，
Scan for full text
Ke-ju, L., Wen-jun, W., Da-jin, L. et al. Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats., Chin. J. Integr. Med. 12, 132–136 (2006). https://doi.org/10.1007/BF02857360

Liu Ke-ju, Wang Wen-jun, Li Da-jin, et al. Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats[J]. Chinese Journal of Integrative Medicine, 2006,12(2):132-136.
Ke-ju, L., Wen-jun, W., Da-jin, L. et al. Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats., Chin. J. Integr. Med. 12, 132–136 (2006). https://doi.org/10.1007/BF02857360 DOI：

Liu Ke-ju, Wang Wen-jun, Li Da-jin, et al. Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats[J]. Chinese Journal of Integrative Medicine, 2006,12(2):132-136. DOI： 10.1007/BF02857360.

摘要

Objective: To observe the effect of Gengnianchun Recipe (GNC) on bone mineral density (BMD)

bone biomechanical parameters and serum lipid level in the bilaterally ovariectomized (OVX) rats and to explore the prophylactic and therapeutic action of GNC on ovariectomy induced osteoporosis and hyperlipidemia.Methods: OVX SD rats

10 –12 months old

were divided into different groups and fed with GNC 2 g/d

GNC 1 g/d and Nilestriol 0. 125 mg/week

respectively for 4 months to observe the change of BMD and bone biomechanical parameters of the lumbar vertebrae

and the serum levels of total cholesterol (TC)

triglyceride(TG)

high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)

and to compare the effect of the two drugs on the morphology of the uterus.Results: There was marked reduction in BMD and biomechanical parameters in lumbar vertebrae (P< 0.01) and increase of serum TC and LDL-C levels (P< 0. 01) in rats after OVX. GNC or Nilestriol significantly improved the decreased BMD and biomechanical parameters of the lumbar vertebrae (P< 0.05 orP< 0.01)

and reduced the serum TC and LDL-C levels (P< 0.01). In the Nilestriol group

the wet weight of uterus got increased obviously (P< 0.01)

the number of uterine glands increased

uterine columnar epithelium thickened

and the mitotic figures in the epithelial stroma and myointimal cells augmented. But no such effect in wet weight and morphology of uterus was found in the GNC group.Conclusion: GNC could increase the BMD and biomechanical parameters of the lumbar vertebrae

reduce the serum TC and LDL-C levels

yet produce no adverse reaction in stimulating proliferation and hypertrophy of uterus.

Abstract

Objective: To observe the effect of Gengnianchun Recipe (GNC) on bone mineral density (BMD)

10 –12 months old

were divided into different groups and fed with GNC 2 g/d

GNC 1 g/d and Nilestriol 0. 125 mg/week

respectively for 4 months to observe the change of BMD and bone biomechanical parameters of the lumbar vertebrae

and the serum levels of total cholesterol (TC)

triglyceride(TG)

high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)

and reduced the serum TC and LDL-C levels (P< 0.01). In the Nilestriol group

the wet weight of uterus got increased obviously (P< 0.01)

the number of uterine glands increased

uterine columnar epithelium thickened

reduce the serum TC and LDL-C levels

yet produce no adverse reaction in stimulating proliferation and hypertrophy of uterus.

关键词

Gengnianchun Recipepostmenopausal osteoporosisBone Mineral Densitybone biomechanicsTotal Cholesterollow-density lipoprotein cholesterol

Keywords

Gengnianchun Recipepostmenopausal osteoporosisBone Mineral Densitybone biomechanicsTotal Cholesterollow-density lipoprotein cholesterol

references

Cao LX, Mao QZ, Yu J. Clinical study of Gengnianchun on climacteric syndrome. Shanghai J Tradit Chin Med 1997; 31 (2): 33–35.

Wang WJ, Yu J, Wang J. The Prevention of “Gengnianchun” on experimental primary osteoporosis in rats. Shanghai J Tradit Chin Med 2001; 35 (11): 47–49.

Wang WJ, Yu J, Wang J, et al. Effect of Gengnianchun on the pathomorphology of experimental primary osteoporosis. J Shanghai Med Univ 2000; 27(1): 54–56.

Seidlova-Wuttke D, Jarry H, Becher T, et al. Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus. Maturitas 2003; 44 (Suppl 1): S39-S50.

Ceinos AM, Acosta EE, Martin PC, et al. Risk factors related to osteoporosis and age of onset of menopause in the general population. Aten Primaria 1999; 24(3): 140–144.

Rosenberg L, Hennekens CH, Rosner B, et al. Early menopause and the risk of myocardial infarction. Am J Obstet Gynecol 1981; 139(1): 47–51.

Suda Y, Ohta H, Makita K, et al. Influence of bilateral oophorectomy upon lipid metabolism. Maturitas 1998; 29 (2): 147–154.

Genant HK, Baylink DJ, Gallagher JC. Estrogens in the prevention of osteoporosis in postmenopausal women. Am J Obstet Gynecol 1989; 161 (6Pt2): 1842–1846.

Stampfer MJ, Colditz GA, Willett WC, et al. Postmenopausal estrogen therapy and cardiovascular disease: ten-year follow up from the nurses’ health study. N Engl J Med 1991; 325(11): 756–762.

Henderson BE, Ross R, Pike MC. Hormonal chemoprevention of cancer in women. Science 1993; 259(5095): 633–638.

Shiomi M, Ito T, Watanabe Y. Increase in hepatic lowdensity lipoprotein receptor activity during pregnancy in Watanabe heritable hyperlipidemia rabbits: an animal model for familial hypercholesterolemia. Biochem Biophys Acta 1987; 917(1): 92–100.

Mabuchi H, Sakai Y, Watanabe A, et al. Normalization of low-density lipoprotein levels and disappearance of xanthomas during pregnancy in a woman with heterozygous familial hypercholesterolemia. Metabolism 1985; 34(4): 309–315.

Honjo H, Tanaka K, Urabe M, et al. Menopause and hyperlipidemia: pravastain lowers lipid levels without decreasing endogenous estrogen. Clin Ther 1992; 14 (5): 699–707.

Abbey M, Owen A, Suzakawa M, et al. Effects of menopause and hormone replacement therapy on plasms lipids, lipoproteins and LDL-receptor activity. Maturitas 1999; 33 (3): 259–269.

He Y, Lam TH, Li LS, et al. Triglyceride and coronary heart disease mortality in a 24-year follow-up study in Xi’ an, China. Ann Epidemiol 2004; 14(1): 1–7.

FULL TEXT LINK

More>

浏览量

326

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Clinical practice guideline of traditional medicine for primary osteoporosis

An innovative herbal product for the prevention of osteoporosis

The more efficacious acupoints of Zusanli and Sanyinjiao than that of non-acupoints on bone mass in osteopenic Ovariectomized rats

A clinical study of Yigu capsule in treating postmenopausal osteoporosis

Study on preventive effect of jiangu granule on osteoporosis in ovariectomized rats