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Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats
Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats
- 中国结合医学杂志（英文版） 2006年12卷第2期 页码：137-141
- Affiliations：
1. Department of Pharmacology, First Military Medical University,Guangzhou
2. Qixing Pharmaceutical Co. Ltd.,Guangzhou
- Author bio：
- Funds：Supported by the Social Development Research Program of Department of Science and Technology of Guangdong Province (No. 2KB04207S)
DOI：10.1007/BF02857361
中图分类号：纸质出版日期：2006，
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Hang-yu, W., Jiang-ping, X., Lin, L. et al. Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats., Chin. J. Integr. Med. 12, 137–141 (2006). https://doi.org/10.1007/BF02857361
Wu Hang-yu, Xu Jiang-ping, Li Lin, et al. Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats[J]. Chinese Journal of Integrative Medicine, 2006,12(2):137-141.
Hang-yu, W., Jiang-ping, X., Lin, L. et al. Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats., Chin. J. Integr. Med. 12, 137–141 (2006). https://doi.org/10.1007/BF02857361 DOI：
Wu Hang-yu, Xu Jiang-ping, Li Lin, et al. Effects of Yizhi Capsule on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats[J]. Chinese Journal of Integrative Medicine, 2006,12(2):137-141. DOI： 10.1007/BF02857361.
摘要
Objective: To explore the effects of Yizhi Capsule (YZC) on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats.Methods: Various doses of YZC were administered to Sprague-Dawley (SD) rats for 8 consecutive days
twice a day. On the 8th day of the experiment
scopolamine hydrobromide was intraperitoneally injected to every rat and Morris water maze test and shuttle dark avoidance test were carried out respectively to explore the changes of learning and memory capacities in the rats. Besides
after the cerebral cortical neurons of newborn SD rats aged within 3 days were culturedin vitro for 7 days
drug serum containing YZC was added to the cultured neurons before or after β amyloid peptide25–35 (Aβ25–35) intoxication to observe the protective effect of YZC on neurotoxicity by MTT assay and to determine the LDH content in the supernatant.Results: Compared with those untreated with YZC
the rats having received YZC treatment got superiority in shorter time of platform seeking in Morris water maze test
as well as elongated latent period and less times of error in shuttle dark avoidance test. On the cultured neurons
YZC drug serum could effectively increase the survival rate of Aβ25–35 intoxicated neurons and reduce the LDH contents in cultured supernatant.Conclusion: YZC has an action of improving learning and memory disorder
and good protective effect on Aβ25–35 induced neurotoxicity in SD rats.
Abstract
Objective: To explore the effects of Yizhi Capsule (YZC) on learning and memory disorder and β-amyloid peptide induced neurotoxicity in rats.Methods: Various doses of YZC were administered to Sprague-Dawley (SD) rats for 8 consecutive days
twice a day. On the 8th day of the experiment
scopolamine hydrobromide was intraperitoneally injected to every rat and Morris water maze test and shuttle dark avoidance test were carried out respectively to explore the changes of learning and memory capacities in the rats. Besides
after the cerebral cortical neurons of newborn SD rats aged within 3 days were culturedin vitro for 7 days
drug serum containing YZC was added to the cultured neurons before or after β amyloid peptide25–35 (Aβ25–35) intoxication to observe the protective effect of YZC on neurotoxicity by MTT assay and to determine the LDH content in the supernatant.Results: Compared with those untreated with YZC
the rats having received YZC treatment got superiority in shorter time of platform seeking in Morris water maze test
as well as elongated latent period and less times of error in shuttle dark avoidance test. On the cultured neurons
YZC drug serum could effectively increase the survival rate of Aβ25–35 intoxicated neurons and reduce the LDH contents in cultured supernatant.Conclusion: YZC has an action of improving learning and memory disorder
and good protective effect on Aβ25–35 induced neurotoxicity in SD rats.
关键词
learning and memory disorderβ-amyloid peptideneurotoxicity
Keywords
learning and memory disorderβ-amyloid peptideneurotoxicity
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