Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4

Wang Jian; Yang Feng-zhen; Zhao Min; Zhang Yun-hui; Zhang Yong-xiang; Liu Ying; Liu Wei-min; Wang Fu-sheng; Xu Shu-ling; Yu Zhi-min; Xie Yan-ming; Zhou Xian-zhi; Iang Tian-jun

doi:10.1007/BF02857422

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Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4

OriginalPaper | Updated：2021-08-27

- Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4
- Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4
- 中国结合医学杂志（英文版） 2006年12卷第1期页码：6-11
- Affiliations：
  
  1. Department of AIDS, Institute of Basic Theory, China Academy of Chinese Medical Sciences,Beijing
  2. The Hospital of PLA,China,302
- Author bio：
- Funds：
  
  Supported by the Projects of Ministry of Science and Technology for 10th Five-year Plan (2001BA701A18)
- DOI：10.1007/BF02857422
  中图分类号：
- 纸质出版日期：2006，
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Jian, W., Feng-zhen, Y., Min, Z. et al. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4., Chin. J. Integr. Med. 12, 6–11 (2006). https://doi.org/10.1007/BF02857422

Wang Jian, Yang Feng-zhen, Zhao Min, et al. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4[J]. Chinese Journal of Integrative Medicine, 2006,12(1):6-11.
Jian, W., Feng-zhen, Y., Min, Z. et al. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4., Chin. J. Integr. Med. 12, 6–11 (2006). https://doi.org/10.1007/BF02857422 DOI：

Wang Jian, Yang Feng-zhen, Zhao Min, et al. Randomized double-blinded and controlled clinical trial on treatment of HIV/AIDS by Zhongyan-4[J]. Chinese Journal of Integrative Medicine, 2006,12(1):6-11. DOI： 10.1007/BF02857422.

摘要

Objective: To assess the efficacy and safety of Zhongyan-4 (ZY-4

a Chinese herbal preparation worked out according to the therapeutic principle of supplementing qi

nourishing Yin

clearing heat and detoxication) in treating HIV/AIDS patients in the early or middle stage.Methods: Adopted was randomized double-blinded and placebo-parallel-controlled method

with 72 HIV/AIDS patients randomly divided into the ZY-4 group (36 patients) treated with ZY-4 and the control group (36 patients) treated with placebo. The treatment course was six months. The index of CD 4 +

CD 8 + counts

body weight

clinical symptom scoring were estimated at 4 time points (0

3 and 6 month in the course)

and also the viral load before and after treatment. The whole course of observation was completed in 63 patients

30 in the ZY-4 group and 33 in the control group.Results: CD 4 + count in the ZY-4 group got elevated by 7.70 ± 150.96/mm3 on average

while that in the control group lowered by 27.33 ± 85.28 /mm3. Fifteen out of the 30 patients in the ZY-4 group had their CD 4 + count increased

which was evidently much higher than that in the control group (8/33

P<0.05)

suggesting that the efficacy of ZY-4 is superior to that of placebo in elevating CD 4 + count. Moreover

ZY-4 showed actions in elevating CD45RA+ and CD 8 + count

reducing HIV virus load

improving clinical symptom/sign and increasing body weight of patients. No obvious adverse reaction was found in the clinical trial.Conclusion: ZY-4 has an immunity-protective and/or rebuilding function in HIV/AIDS patients in the early and middle stage

and also shows effects in lowering viral load

increasing body weight and improving symptoms and signs to a certain degree.

Abstract

Objective: To assess the efficacy and safety of Zhongyan-4 (ZY-4

a Chinese herbal preparation worked out according to the therapeutic principle of supplementing qi

nourishing Yin

clearing heat and detoxication) in treating HIV/AIDS patients in the early or middle stage.Methods: Adopted was randomized double-blinded and placebo-parallel-controlled method

CD 8 + counts

body weight

clinical symptom scoring were estimated at 4 time points (0

3 and 6 month in the course)

and also the viral load before and after treatment. The whole course of observation was completed in 63 patients

30 in the ZY-4 group and 33 in the control group.Results: CD 4 + count in the ZY-4 group got elevated by 7.70 ± 150.96/mm3 on average

while that in the control group lowered by 27.33 ± 85.28 /mm3. Fifteen out of the 30 patients in the ZY-4 group had their CD 4 + count increased

which was evidently much higher than that in the control group (8/33

P<0.05)

suggesting that the efficacy of ZY-4 is superior to that of placebo in elevating CD 4 + count. Moreover

ZY-4 showed actions in elevating CD45RA+ and CD 8 + count

reducing HIV virus load

and also shows effects in lowering viral load

increasing body weight and improving symptoms and signs to a certain degree.

关键词

HIV/AIDSprinciple for supplementing Qinourishing Yinclearing heat and detoxicationZhongyan-4T-Iymphocyte subsetsHIV viral load

Keywords

HIV/AIDSprinciple for supplementing Qinourishing Yinclearing heat and detoxicationZhongyan-4T-Iymphocyte subsetsHIV viral load

references

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Jiang XY. The pathogenesis of AIDS. J Chin Med 2001; 16(6): 41–42.

Huang BS. The treatment of AIDS with TCM. Harbin: Heilongjiang Science and Technology Publishing House, 1990: 25.

Xue BS. The knowledge of HIV/AIDS with TCM theory. J Tradit Chin Med 1991;32(1): 20.

Yang FZ, Yan JH. Exploring Yuan Qi theory in HIV/AIDS. J Basic Theory Tradit Chin Med 2003; 9(8): 4–5.

Yang FZ. Wang J. Developing research of HIV/AIDS in the TCM pathogenesis. J Inform Tradit Chin Med 2004; 11 (4): 365–367.

Zhao WS. Present clinical immunology. Beijing: People’s Miltary Publication Press, 1994: 683–686.

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Jian TJ, Zhao M.Wang J, et al. Clinical research of liver damage of HIV complicated with HCV infection. J New Chin Materia Med 2004; 3(4): 22–24.

Yang FZ, Wang J, Zhao M, et al. The relativity research of traditional Chinese medicine syndromes and T lymphocyte and virus loading. China J Tradit Chin Med Pharmacy 2004: 19(12): 733–737.

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