Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin

Li Yuan; Gui Hui-juan; Huang Jin-chang; Wu Xiao-qin

doi:10.1007/BF02857424

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Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin

OriginalPaper | Updated：2021-08-27

- Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin
- Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin
- 中国结合医学杂志（英文版） 2006年12卷第1期页码：19-23
- Affiliations：
  
  Department of Oncology, China-Japan Friendship Hospital,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02857424
  中图分类号：
- 纸质出版日期：2006，
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Yuan, L., Hui-juan, G., Jin-chang, H. et al. Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin., Chin. J. Integr. Med. 12, 19–23 (2006). https://doi.org/10.1007/BF02857424

Li Yuan, Gui Hui-juan, Huang Jin-chang, et al. Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin[J]. Chinese Journal of Integrative Medicine, 2006,12(1):19-23.
Yuan, L., Hui-juan, G., Jin-chang, H. et al. Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin., Chin. J. Integr. Med. 12, 19–23 (2006). https://doi.org/10.1007/BF02857424 DOI：

Li Yuan, Gui Hui-juan, Huang Jin-chang, et al. Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin[J]. Chinese Journal of Integrative Medicine, 2006,12(1):19-23. DOI： 10.1007/BF02857424.

摘要

Objective: To evaluate the efficacy of Jiawei Huangqi Guizhi Wuwu Decoction (JHGWD) in treating neuro-sensory toxicity induced by oxaliplatin.Methods: A randomized controlled self-crossover trial was performed. Thirty-one patients were randomly divided into AB and BA groups. Patients in A cycle belonged to the treated group

who were treated with chemotherapy combined with oxaliplatin plus JHGWD. Patients in B cycle belonged to the control group and were treated with chemotherapy alone. The peripheral neuro-sensory toxicity was observed and analyzed.Results: The main neurotoxicity was cold-induced paresthesia after the use of oxaliplatin

which included hyperaesthesia

chill

anaesthesia in the extremities

electrified sensation

formication

foreign body sensation and pain that might be exacerbated by exposure to cold. Twenty patients (64.5%) suffered from neuro-sensory toxicity in the treated group and 27 cases (87. 1%) in the control group. Symptoms were more serious and lasted longer in the control group than those in the treated group (P<0.01).Conclusion: JHGWD could prevent and reduce the occurence and intensity of acute peripheral neuro-sensory toxicity caused by oxaliplatin.

Abstract

which included hyperaesthesia

chill

anaesthesia in the extremities

electrified sensation

formication

关键词

oxaliplatinneurological toxicityJiawei Huangqi Guizhi Wuwu Decoctionprevention and treatment

Keywords

oxaliplatinneurological toxicityJiawei Huangqi Guizhi Wuwu Decoctionprevention and treatment

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