Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds

Li Fen; Wu Hong; Deng Jun-wei; Fan Song-qing; Tian Jing; Gao Jie-sheng; Zhu Ya-hui; Lu Guang-xiu

doi:10.1007/BF02857430

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Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds

OriginalPaper | Updated：2021-08-27

- Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds
- Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds
- 中国结合医学杂志（英文版） 2006年12卷第1期页码：46-49
- Affiliations：
  
  1. Department of Rheumatology and Clinic Immunology, TheSecond Xiangya Hospital of Central-South University,Changsha
  2. Medical Research Center, The Second Xiangya Hospital of Central-South University,China
  3. Department of Pathology, The Second Xiangya Hospital of Central-South University,China
  4. Human Procreate Engineering Laboratory, Xiangya College of Central-South University,China
- Author bio：
- Funds：
- DOI：10.1007/BF02857430
  中图分类号：
- 纸质出版日期：2006，
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Fen, L., Hong, W., Jun-wei, D. et al. Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds., Chin. J. Integr. Med. 12, 46–49 (2006). https://doi.org/10.1007/BF02857430

Li Fen, Wu Hong, Deng Jun-wei, et al. Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds[J]. Chinese Journal of Integrative Medicine, 2006,12(1):46-49.
Fen, L., Hong, W., Jun-wei, D. et al. Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds., Chin. J. Integr. Med. 12, 46–49 (2006). https://doi.org/10.1007/BF02857430 DOI：

Li Fen, Wu Hong, Deng Jun-wei, et al. Effect of Yangqixue Qufengshi Recipe on rheumatoid arthritis model mice under different genetic backgrounds[J]. Chinese Journal of Integrative Medicine, 2006,12(1):46-49. DOI： 10.1007/BF02857430.

摘要

Objective: To study the effect of Yangqixue Qufengshi Recipe (YQXQFS) on rheumatoid arthritis (RA) model mice under different genetic backgrounds.Methods: Collagen Induced Arthritis (CIA) were established on HLA-DR4 transgenic (TG) mice and non-transgenic (NTG) mice

which partly were raised with YQXQFS

and the onset day of CIA

the level of type II collagen (C II)-reactive antibodies and the pathological scores of CIA were assessed.Results: Under HLA-DR4 TG background (compared with NTG mice)

the earlier onset day of CIA (11.22 ± 3.35 days vs 16.56 ± 4.75 days

P<0.05) and higher level of C II-reactive antibodies (0.2274 ± 0. 1390 μg/ml vs 0. 1101 ± 0.0560 μg/ml

P<0.05) were observed

but the pathological scores of CIA remained unchange. YQXQFS could not influence the onset day of CIA and the level of CII -reactive antibodies

but had a certain effect on the total pathological scores (6.56 ± 3.43 scores vs 11.11 ± 5.64 scores) and bone erosion (0.22 ± 0.44 scores vs 1.67 ± 1.50 scores) of CIA on NTG mice (P<0.05)

NTG YQXQFS group compared with NTG experimental group.Conclusion: YQXQFS had a certain effect on RA model

but had no significant effect on HLA-DR4 related CIA.

Abstract

which partly were raised with YQXQFS

and the onset day of CIA

the level of type II collagen (C II)-reactive antibodies and the pathological scores of CIA were assessed.Results: Under HLA-DR4 TG background (compared with NTG mice)

the earlier onset day of CIA (11.22 ± 3.35 days vs 16.56 ± 4.75 days

P<0.05) and higher level of C II-reactive antibodies (0.2274 ± 0. 1390 μg/ml vs 0. 1101 ± 0.0560 μg/ml

P<0.05) were observed

but the pathological scores of CIA remained unchange. YQXQFS could not influence the onset day of CIA and the level of CII -reactive antibodies

but had a certain effect on the total pathological scores (6.56 ± 3.43 scores vs 11.11 ± 5.64 scores) and bone erosion (0.22 ± 0.44 scores vs 1.67 ± 1.50 scores) of CIA on NTG mice (P<0.05)

NTG YQXQFS group compared with NTG experimental group.Conclusion: YQXQFS had a certain effect on RA model

but had no significant effect on HLA-DR4 related CIA.

关键词

rheumatoid arthritiscollagen induced arthritisHLA-DR4transgenic miceYangqixue Qufengshi Recipe

Keywords

rheumatoid arthritiscollagen induced arthritisHLA-DR4transgenic miceYangqixue Qufengshi Recipe

references

Wagner U, Kaltenhauser S, Sauer H, et al. HLA markers and prediction of clinical course and outcome in rheumatoid arthritis. Arthritis Rheum 1997;40(2): 341–351.

Li F, Wu H, Deng JW, et al. Study on susceptible gene of rheumatoid arthritis by transgenic animal. Chin J Rheumatol 1999; 3(2): 75–79.

Wu H, Gao JS, Li M, et al. Relationship between frequency of rheumatoid arthritis patients expressing HLA-DR4 alleles and effect of combined DMARDs therapy. Chin J Rheumatol 2001; 5(4): 213–215.

Deng JW, Wu H, You XK, et al. Construction and expression of HLA-DRα, DRB1 * 0401 transgenic mice model. Chin J Med Genet 1999; 16(6): 360–363.

Williams PJ, Jones RH, Rademacher TW. Reduction in the incidence and severity of collagen-induced arthritis in DBA/1 using exogenous dehydroepiandrosterone. Arthritis Rheum 1997; 40(5): 907–911.

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