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Current status of clinical and experimental researches on cognitive impairment in diabetes
Current status of clinical and experimental researches on cognitive impairment in diabetes
- 中国结合医学杂志（英文版） 2006年12卷第1期 页码：68-74
- Affiliations：
1. Peking Union Medical College Hospital, Chinese Academy of Medical Science,Beijing
2. Laboratory of Kampo medicine, Department of Cellular and Structural biology, The Texas Health Science Center at San Antonio,USA
- Author bio：
- Funds：
DOI：10.1007/BF02857437
中图分类号：纸质出版日期：2006，
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Xiao-chun, L., Sai-shan, G. & Hagino, N. Current status of clinical and experimental researches on cognitive impairment in diabetes., Chin. J. Integr. Med. 12, 68–74 (2006). https://doi.org/10.1007/BF02857437
Liang Xiao-chun, Guo Sai-shan, Nobuyoshi Hagino. Current status of clinical and experimental researches on cognitive impairment in diabetes[J]. Chinese Journal of Integrative Medicine, 2006,12(1):68-74.
Xiao-chun, L., Sai-shan, G. & Hagino, N. Current status of clinical and experimental researches on cognitive impairment in diabetes., Chin. J. Integr. Med. 12, 68–74 (2006). https://doi.org/10.1007/BF02857437 DOI：
Liang Xiao-chun, Guo Sai-shan, Nobuyoshi Hagino. Current status of clinical and experimental researches on cognitive impairment in diabetes[J]. Chinese Journal of Integrative Medicine, 2006,12(1):68-74. DOI： 10.1007/BF02857437.
摘要
This article reviews the clinical and experimental researches on cognitive impairment related to diabetes in the recent decade. Most clinical studies indicate that the cognitive impairment in patients with type 1 diabetes mellitus is related to recurrent hypoglycemia closely. There is little research about whether or not hyperglycemia is related to cognitive impairment in patients with type 1 diabetes mellitus. Most studies indicate that the cognitive impairment in type 2 diabetes involves multiple factors through multiple mechanisms
including blood glucose
blood lipid
blood pressure
level of insulin
medication
chronic complication
etc. But
there has been no large-scale
multi-center
randomized controlled clinical trial in China recently. And what is more
some problems exist in this field of research
such as the lack of golden criterion of cognitive function measurement
different population of studied objects
and incomprehensive handling of confounding factors. Experimental studies found that hippocampal long-term potentiation (LTP) was impaired
which were manifested by impairment of spatial memory and decreased expression of LTP
but its relation to hyperglycemia
the duration of diabetes
learning and memory has always been differently reported by different researches. Thus
there are a lot of unknown things to be explored and studied in order to clarify its mechanism. TCM has abundant clinical experience in treating cerebral disease with medicine that enforces the kidney and promotes wit. However
there has been no research on treating diabetic cognitive impairment
which requires work to be done actively and TCM to be put into full play
in order to improve the treatment of diabetes and enhance living quality of patients.
Abstract
This article reviews the clinical and experimental researches on cognitive impairment related to diabetes in the recent decade. Most clinical studies indicate that the cognitive impairment in patients with type 1 diabetes mellitus is related to recurrent hypoglycemia closely. There is little research about whether or not hyperglycemia is related to cognitive impairment in patients with type 1 diabetes mellitus. Most studies indicate that the cognitive impairment in type 2 diabetes involves multiple factors through multiple mechanisms
including blood glucose
blood lipid
blood pressure
level of insulin
medication
chronic complication
etc. But
there has been no large-scale
multi-center
randomized controlled clinical trial in China recently. And what is more
some problems exist in this field of research
such as the lack of golden criterion of cognitive function measurement
different population of studied objects
and incomprehensive handling of confounding factors. Experimental studies found that hippocampal long-term potentiation (LTP) was impaired
which were manifested by impairment of spatial memory and decreased expression of LTP
but its relation to hyperglycemia
the duration of diabetes
learning and memory has always been differently reported by different researches. Thus
there are a lot of unknown things to be explored and studied in order to clarify its mechanism. TCM has abundant clinical experience in treating cerebral disease with medicine that enforces the kidney and promotes wit. However
there has been no research on treating diabetic cognitive impairment
which requires work to be done actively and TCM to be put into full play
in order to improve the treatment of diabetes and enhance living quality of patients.
关键词
diabetesimpairment of cognitivememory and learning
Keywords
diabetesimpairment of cognitivememory and learning
references
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