Objective: To explore the therapeutic effect and its mechanism mainly using traditional Chinese medicine (TCM) of Replenishing Qi and Nourishing Yin (RQNY) with a small dosage of Tapazole for treatment of Graves’ disease (GD).Methods: The changes of thyroid function and the activity of sodium pump of human erythrocyte in the patients with Graves’ disease were observed and compared before and after treatment between the treated group (42 cases) by combining treatment mainly using TCM of RQNY and a small amount of Tapazole and a control group (42 cases) by Tapazole alone.Results: After treatment for half a year

one and two years

the serum levels of T3

T4 in above two groups were markedly decreased than those of before treatment

the therapeutic effect of treated group was superior to that of the control group. The activity of sodium pump in human erythrocyte in the GD patients was obviously higher than that of normal group and that of before treatment. After treatment for one and two years mainly by TCM or western medicine

the erythrocyte sodium pump activity was obviously lower than that of normal group and that of before treatment. The decrease of erythrocyte sodium pump activity in the treated group was markedly lower than that in the control group.