Serum pharmacological effects of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis in rats) on Ito cell proliferation and collagen synthesis in rats

Ping Liu; Chenghai Liu; Cheng Liu; Lieming Xu

doi:10.1007/BF02934157

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Serum pharmacological effects of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis in rats) on Ito cell proliferation and collagen synthesis in rats

OriginalPaper | Updated：2021-08-27

- Serum pharmacological effects of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis in rats) on Ito cell proliferation and collagen synthesis in rats
- Serum pharmacological effects of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis in rats) on Ito cell proliferation and collagen synthesis in rats
- 中国结合医学杂志（英文版） 1998年4卷第2期页码：118-122
- Affiliations：
  
  Institute of Liver Diseases, Shanghai Academy of Traditional Chinese Medicine,Shanghai
- Author bio：
- Funds：
  
  Grant by National Natural Science Foundaticn of China (No.39670889)
- DOI：10.1007/BF02934157
  中图分类号：
- 纸质出版日期：1998，
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Liu, P., Liu, C., Liu, C. et al. Serum pharmacological effects of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis in rats) on Ito cell proliferation and collagen synthesis in rats., CJIM 4, 118 (1998). https://doi.org/10.1007/BF02934157

Ping Liu, Chenghai Liu, Cheng Liu, et al. Serum pharmacological effects of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis in rats) on Ito cell proliferation and collagen synthesis in rats[J]. Chinese Journal of Integrative Medicine, 1998,4(2):118-122.
Liu, P., Liu, C., Liu, C. et al. Serum pharmacological effects of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis in rats) on Ito cell proliferation and collagen synthesis in rats., CJIM 4, 118 (1998). https://doi.org/10.1007/BF02934157 DOI：

Ping Liu, Chenghai Liu, Cheng Liu, et al. Serum pharmacological effects of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis in rats) on Ito cell proliferation and collagen synthesis in rats[J]. Chinese Journal of Integrative Medicine, 1998,4(2):118-122. DOI： 10.1007/BF02934157.

摘要

Objective: To explore mechanism of the effect of Fuzheng Huayu Decoction on Ito cell proliferation and collagen synthesis.Methods: Biological effects of the drug serum taken from rats fed with Fuzheng Huayu decoction (FZHYD) on cell proliferation and collagen synthesis of Ito cell line were observed. Serum collected from rats at various times (1

2 or 3 hours) after animals were fed with FZHYD once (It) or twice (2t

2nd time repeated with the same dose)

was incubated with Ito cell.Results: The lt-2h serum in 0. 46 g/kg FZHYD group

it seems to prevent cell proliferation

but had no significant difference. While all 2t drug serum could inhibit cell proliferation. The 2t-lh drug serum had no obvious effects on Ito cell morphology

but could improve cell viability

its effect on cell proliferation was dose and serum concentration dependent. Also the 2t-lh drug serum in all doses could inhibit Ito cells both intracellular and extracellular collagen production

the drug serum of 0.46 g/kg group had inhibitory effect in serum concentration dependent manner and similar effect as colchicine.Conclusion: Inhibition of Ito cells proliferation and collagen synthesis is perhaps one of main mechanism of FZHYD in antifibrotic action.

Abstract

2 or 3 hours) after animals were fed with FZHYD once (It) or twice (2t

2nd time repeated with the same dose)

was incubated with Ito cell.Results: The lt-2h serum in 0. 46 g/kg FZHYD group

it seems to prevent cell proliferation

but had no significant difference. While all 2t drug serum could inhibit cell proliferation. The 2t-lh drug serum had no obvious effects on Ito cell morphology

but could improve cell viability

its effect on cell proliferation was dose and serum concentration dependent. Also the 2t-lh drug serum in all doses could inhibit Ito cells both intracellular and extracellular collagen production

关键词

Fuzheng Huayu DecoctionIto cellcollagencell proliferation

Keywords

Fuzheng Huayu DecoctionIto cellcollagencell proliferation

references

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