Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C

Jiqiang Li; Chaoqun Li; Minde Zeng; Xiangkui She; Guoqin Li; Jing Hua; Dekai Qiu; Shudong Xiao

doi:10.1007/BF02934185

Your Location：

Home >

Browse articles >

Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C

OriginalPaper | Updated：2021-08-27

- Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C
- Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C
- 中国结合医学杂志（英文版） 1999年5卷第1期页码：29-31
- Affiliations：
  
  1. Renji Hospital of Shanghai Second Medical University,Shanghai
  2. Xiangfan Central Hospital of Hubei Provine,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934185
  中图分类号：
- 纸质出版日期：1999，
Scan for full text
Li, J., Li, C., Zeng, M. et al. Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C., CJIM 5, 29–31 (1999). https://doi.org/10.1007/BF02934185

Jiqiang Li, Chaoqun Li, Minde Zeng, et al. Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C[J]. Chinese Journal of Integrative Medicine, 1999,5(1):29-31.
Li, J., Li, C., Zeng, M. et al. Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C., CJIM 5, 29–31 (1999). https://doi.org/10.1007/BF02934185 DOI：

Jiqiang Li, Chaoqun Li, Minde Zeng, et al. Preliminary study on efficacy of oxymatrine in treatment of patients with chronic hepatitis C[J]. Chinese Journal of Integrative Medicine, 1999,5(1):29-31. DOI： 10.1007/BF02934185.

摘要

Objective: To evaluate the efficacy of oxymatrine in the treatment of chronic hepatitis C and to discuss its mechanism.Methods: Forty-three patients with chronic HCV infection were randomly divided into the treated group (20 cases) and the control group (23 cases). The treated group was given oxymatrine 600 mg per day intramuscularly for three months

and the control group was given the general liver protective agents such as vitamins. Serum HCV-RNA

alanine aminotransferase (ALT)

soluble interleukin-2 receptor and collagen type IV (IV-C) were determined before and after treatment.Results: Eight out of 17 HCV-RNA-positive (47.1%) in the treated group converted to HCV-RNA-negative cases

while in 18 cases of the control group

the negative convertion only took place in 1 patient (5.6%)

the negative conversion rate was significantly higher in the treated group than that in the control group (P < 0.05). The normalization rates of serum ALT of the treated group at the end of the first and second month treatment were higher than those of the control group

but after three months treatment

the normalization rates of the two groups were not different significantly. Both serum levels of IV-C and plasma levels of soluble interleukin-2 receptor were significantly reduced after oxymatrine treatment for three months (P < 0.05).Conclusion: Oxymatrine is effective on eliminating HCV-RNA and reducing fibrosis activity

so it could be a safe

effective drug in the treatment of chronic hepatitis C.

Abstract

and the control group was given the general liver protective agents such as vitamins. Serum HCV-RNA

alanine aminotransferase (ALT)

while in 18 cases of the control group

the negative convertion only took place in 1 patient (5.6%)

but after three months treatment

so it could be a safe

effective drug in the treatment of chronic hepatitis C.

关键词

Oxymatrinehepatitis C virus ribonucleic acidsoluble interleukin-2 receptorcollagen type III

Keywords

Oxymatrinehepatitis C virus ribonucleic acidsoluble interleukin-2 receptorcollagen type III

references

Hoofnagie JH, Di Bisceglie AM. Antiviral therapy of viral hepatitis. In: Galasso GJ, Whitley RJ, Merigan TC (Eds). Antiviral agents and viral diseases of man. 3rd ed. New York: Raven Press, 1990.

1991; 11(2): 140–142.

1990; 29(ll): 648.

1996; 17(5): 424–426.

B 3 1995; 9(2): 115–117.

1992; 12(7): 398–401.

Jun H, Yasuhiro K, Kouxzburo Y, et al. Serum levels of soluble interleukin-2 receptors and effect of interferon for patients with chronic hepatits C virus. Dig Dis Sci 1995; 40(8): 1837.

Yabu K, Kiyosawa K, Mori H, et al. Serum collagen type IV for the assessment of fibrosis and resistance to interferon therapy in chronic hepatitis C. Scand J Gastroenterol 1994; 29(5): 474–479.

1996; 16(6): 413–514.

FULL TEXT LINK

More>

浏览量

357

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Role of β2-adrenoceptor-β-arrestin2-nuclear factor-κB signal transduction pathway and intervention effects of oxymatrine in ulcerative colitis

Effect of oxymatrine on hepatic gene expression profile in experimental liver fibrosis of rats

Effect of Kang’ ai Injection (康艾注射液) on serum level of soluble interleukin-2 receptor and vascular endothelial growth factor in patients with esophageal carcinoma during radiotherapy

Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus