Effect of total saponins of Ginseng leaves on immunity in aged rats

Zhang Kejian; Liu Gengtao

doi:10.1007/BF02934191

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Effect of total saponins of Ginseng leaves on immunity in aged rats

OriginalPaper | Updated：2021-08-27

- Effect of total saponins of Ginseng leaves on immunity in aged rats
- Effect of total saponins of Ginseng leaves on immunity in aged rats
- 中国结合医学杂志（英文版） 1999年5卷第1期页码：50-53
- Affiliations：
  
  1. Beijing Hospital, National Center for Clinical Laboratories,Beijing
  2. Institute of Materia Medica, Chinese Academy of Medical Sciences,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02934191
  中图分类号：
- 纸质出版日期：1999，
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Kejian, Z., Gengtao, L. Effect of total saponins of Ginseng leaves on immunity in aged rats., CJIM 5, 50–53 (1999). https://doi.org/10.1007/BF02934191

Zhang Kejian, Liu Gengtao. Effect of total saponins of Ginseng leaves on immunity in aged rats[J]. Chinese Journal of Integrative Medicine, 1999,5(1):50-53.
Kejian, Z., Gengtao, L. Effect of total saponins of Ginseng leaves on immunity in aged rats., CJIM 5, 50–53 (1999). https://doi.org/10.1007/BF02934191 DOI：

Zhang Kejian, Liu Gengtao. Effect of total saponins of Ginseng leaves on immunity in aged rats[J]. Chinese Journal of Integrative Medicine, 1999,5(1):50-53. DOI： 10.1007/BF02934191.

摘要

Objective: To explore the effect of total saponins of Ginseng leaves(GS) on the functions of neutrophil and lymphocyte in the aged rats of 20 months.Methods: Three groups of aged rats were injected intraperiton-eally with doses of 12.5 mg/kg

25 kg/mg and 50 mg/kg of GS once daily for 3 days

the declined immunity of spleen lymphocytes (proliferation of spleen lymphocyte

phagocytosis)

superoxide anion and nitric oxide formation were studied and were compared with those of young rats (2 months).Results: The declined immunity of spleen lymphocytes were improved dose-dependently after GS injected.Conclusion: The results indicate that GS may enhance neutrophil and lymphocyte mediated non-specific and specific defense function in aged rats.

Abstract

25 kg/mg and 50 mg/kg of GS once daily for 3 days

the declined immunity of spleen lymphocytes (proliferation of spleen lymphocyte

phagocytosis)

关键词

ginseng saponinsaged ratsneutrophilslymphocytes

Keywords

ginseng saponinsaged ratsneutrophilslymphocytes

references

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Grisham MB, Ware K, GillelandHE Jr, et al. Neutrophilmediated nitrosamine formation: role of nitric oxide in rats. Gastroenterology 1992; 103: 1260.

Nordin AA and Makinodan T. Humoral immunity in aging. Fedr Proc 1974; 33: 2033.

Hori Y, Perkins EH and Halsall MK. Decline in phyto hemagglutinin responsiveness of spleen cells from aging mice. Proc Soc Exp Biol Med 1973; 144: 48.

Niwa Y, Kasama T, Miyachi Y, et al. Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and logitudinal studies. Life Sci 1989; 44: 1655.

Moncada S and Higgs EA. Endogenous nitric oxide: physiology, pathology and clinical relevance. Eur J Clin Invest 1991c; 21: 361.

1985: 223.

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