Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali

Lu Jin; Zou Dajin; Zhang Jiaqing

doi:10.1007/BF02934193

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Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali

OriginalPaper | Updated：2021-08-27

- Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali
- Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali
- 中国结合医学杂志（英文版） 1999年5卷第1期页码：59-62
- Affiliations：
  
  Department of Endocrinology, Changhai Hospital, The Second Military Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934193
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- 纸质出版日期：1999，
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Jin, L., Dajin, Z. & Jiaqing, Z. Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali., CJIM 5, 59–62 (1999). https://doi.org/10.1007/BF02934193

Lu Jin, Zou Dajin, Zhang Jiaqing. Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali[J]. Chinese Journal of Integrative Medicine, 1999,5(1):59-62.
Jin, L., Dajin, Z. & Jiaqing, Z. Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali., CJIM 5, 59–62 (1999). https://doi.org/10.1007/BF02934193 DOI：

Lu Jin, Zou Dajin, Zhang Jiaqing. Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali[J]. Chinese Journal of Integrative Medicine, 1999,5(1):59-62. DOI： 10.1007/BF02934193.

摘要

Objective: To investigate the preventive effect of Radix Astragali on tumor necrosis factor-α (TNF-a) induced insulin resistance.Methods: Rats were treated orally with Radix Astragali before TNF-α intravenous injection. The changes of K value in glucose-insulin tolerance test

the concentrations of glucagon (GC)

ACTH and lipids in serum and the contents of glycogen

triglyceride (TG) in liver and red quadriceps were tested 4 hours after the injection and compared with the control.Results: Exogenous TNF-α can induce hyperinsulinemia in normal rats

and the K value decreased

the concentration of serum ACTH

GC and lipids all increased

the glycogen contents in liver and red quadriceps muscle decreased

and the liver TG depots increased. Radix Astragali can improve all the parameters significantly except the serum lipids level and liver triglyceride depots.Conclusions: Radix Astragali has preventive effect on insulin resistance induced by TNF-α and is useful in the treatment of type 2 diabetes. The mechanism may be due to the decrease of insulin-antagonistic hormones and the increase of tissue glycogen contents.

Abstract

the concentrations of glucagon (GC)

ACTH and lipids in serum and the contents of glycogen

triglyceride (TG) in liver and red quadriceps were tested 4 hours after the injection and compared with the control.Results: Exogenous TNF-α can induce hyperinsulinemia in normal rats

and the K value decreased

the concentration of serum ACTH

GC and lipids all increased

the glycogen contents in liver and red quadriceps muscle decreased

关键词

tumor necrosis factor-ainsulin resistanceRadix Astragalitype 2 diabetes

Keywords

tumor necrosis factor-ainsulin resistanceRadix Astragalitype 2 diabetes

references

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Van Der Vies J. Two methods for the determination of glycogen in liver. Biochem J 1954; 57:410–416.

Storlien LH, Oakes ND, Pan DA, et al. Syndromes of insulin resistance in the rats: inducement by diet and amelioration with Benfluorex. Diabetes 1993; 42:457–462.

Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 1992; 130:43–52.

Van Der Poll T, Romijin JA, Endert E, et al. Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans. Am J Physiol 1991; 261:E457-E465.

Peraldi P, Xu M, Spiegelman BM. Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. J Clin Invest 1997; 100:1863–1869.

Morimoto Y, Nishikawa K and Ohashi M. KB-R7785, a novel matrix metalloproteinase inhibitor, exerts antidiabetic effect by inhibitory tumor necrosis factor-α production. Lif Sci 1997; 61:795–803.

Chin JE, Dicken M, Tavare JM, et al. Overexpression of protein kinase C isoenzymes α, βI, γ and ε in cells overexpressing the insulin receptor. J Biol Chem 1993; 268:6338–6347.

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