Sixty-eight cases of Non-Insulin Dependent Diabetes Mellitus complicated with Nephropathy were randomly divided into two groups: the treated group

35 cases treated with alcohol extraction of Flos A-belmoschus manihot

Gliclazide and Captopril Tablets; and the control group

33 cases treated with Gliclazide and Captopril Tablets

over a period of 8 weeks. The total effective rate in the treated and control group were 83.87% and 31.03% respectively (P<0.01)

urinary micro-albumin were 31.7 and 76.3mg/L (P<0.05)

proteinuria were 0.41 and 0.77g/24hr (P<0.01)

blood β-microglobulin were 3317.8 and 3473. 1 hg/ml (P<0.05)

urinary β-microglobulin were 367.2 and 641.5ng/ml (P<0.01)

urinary N-acetyl-β-glucosaminidase (NAG) were 26.3 and 66. 7u/L (P<0.01)

plasma lipid peroxide (LPO) were 6.13 and 8.78 nmol/L (P<0. 05)

and plasma superoxide anion were 8.36 and 10.42 kcpm respectively (P<0.05). It was suggested that alcohol extraction ofAbelmoschus manihot could eliminate oxygen free radicals

alleviate renal tubular-interstitial diseases

improve renal function

and reduce proteinuria.