Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3

Qi Guo; Tian-Qing Peng; Ying-Zhen Yang; Quan-Bao Gu; Jian-Xing Zhao

doi:10.1007/BF02934230

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Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3

OriginalPaper | Updated：2021-08-27

- Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3
- Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3
- 中国结合医学杂志（英文版） 1996年2卷第1期页码：64-67
- Affiliations：
  
  1. Shanghai Institute of Cardiovascular Diseases, Zhong Shan Hospital of Shanghai Medical University,Shanghai
  2. Shanghai Institute of Cell Biology, Academia Sinica,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02934230
  中图分类号：
- 纸质出版日期：1996，
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Guo, Q., Peng, TQ., Yang, YZ. et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3., CJIM 2, 64–67 (1996). https://doi.org/10.1007/BF02934230

Qi Guo, Tian-Qing Peng, Ying-Zhen Yang, et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3[J]. Chinese Journal of Integrative Medicine, 1996,2(1):64-67.
Guo, Q., Peng, TQ., Yang, YZ. et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3., CJIM 2, 64–67 (1996). https://doi.org/10.1007/BF02934230 DOI：

Qi Guo, Tian-Qing Peng, Ying-Zhen Yang, et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3[J]. Chinese Journal of Integrative Medicine, 1996,2(1):64-67. DOI： 10.1007/BF02934230.

摘要

Here was investigated the effect of Radix Astragalus Membranaceus (AM) on Ca2+ influx across the myocardial plasma membrane and coxsackie virus B3(CVB3)-RNA replication in cultured neonatal rat heart cells infected with CVB3. It was found that the Ca2+ influx could be inhibited significantly by AM both in heart cells infected with CVB3 for 48 hours and in normal control heart cells. In addition

the Ca2+ influx and the amounts of CVB3-RNA in myocytes simultaneously infected with CVB3 and treated with AM for 48 hours were statistically decreased compared with that in CVB3-infected control cells. These phenomena suggested that AM could exert the effects of decreasing the secondary Ca2+ damages

improving the abnormal myocardial electric activity and inhibiting replication of CVB3-RNA in myocardium. Thus

it is a rational choice to treat patients with AM in viral myocarditis.

Abstract

improving the abnormal myocardial electric activity and inhibiting replication of CVB3-RNA in myocardium. Thus

it is a rational choice to treat patients with AM in viral myocarditis.

关键词

Coxsackie virus B3Viral MyocarditisCa2+ influxRadix Astragalus membranaceus

Keywords

Coxsackie virus B3Viral MyocarditisCa2+ influxRadix Astragalus membranaceus

references

Lawrence HC. Studies of virus-induced myocardial injury in mice: value of the acid mutation on different genetic backgrounds and combined with other mutations. Lab Animal Sci 1993; 43(2): 133.

Huber S, Polgar A, et al. T lymphocyte responses in CVB3-induced murine myocarditis. Scand J Infect Dis 1993; suppl 88: 67.

Tominage M, Matsumori A, Horie M, et al. Activation of Ca-permeable cation channels by myocarditis-associated antibody in guinea pig ventricular myocytes. J Clin Invest 1993; 91: 1231.

Yang Yz, Jin Py, Guo Q, et al. Treatment of experimental Coxsackie B3 viral myocarditis with Astragalus membranaceus in mice. Chin Med J 1990; 103(l): 14.

Rui T, Yang Yz Zhou Ts, et al. Effect of Astragalus membranaceus on electrophysiological activities of acute experimental Coxsackie B3 viral myocarditis in mice. Chin Med J 1993; 8: 203.

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