Antagonistic effect of Poria Cocos on ototoxicity of kanamycin in guinea-pigs

Yao-Chun Liu; Gui-Ying Liu; Ru-Lin Liu; Xiu-Zhen Cheng; Ning Li; Jian-Ping Hou

doi:10.1007/BF02934233

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Antagonistic effect of Poria Cocos on ototoxicity of kanamycin in guinea-pigs

OriginalPaper | Updated：2021-08-27

- Antagonistic effect of Poria Cocos on ototoxicity of kanamycin in guinea-pigs
- Antagonistic effect of Poria Cocos on ototoxicity of kanamycin in guinea-pigs
- 中国结合医学杂志（英文版） 1996年2卷第1期页码：72-74
- Affiliations：
  
  Weifang Medical College,Shandong
- Author bio：
- Funds：
- DOI：10.1007/BF02934233
  中图分类号：
- 纸质出版日期：1996，
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Liu, YC., Liu, GY., Liu, RL. et al. Antagonistic effect of Poria Cocos on ototoxicity of kanamycin in guinea-pigs., CJIM 2, 72–74 (1996). https://doi.org/10.1007/BF02934233

Yao-Chun Liu, Gui-Ying Liu, Ru-Lin Liu, et al. Antagonistic effect of Poria Cocos on ototoxicity of kanamycin in guinea-pigs[J]. Chinese Journal of Integrative Medicine, 1996,2(1):72-74.
Liu, YC., Liu, GY., Liu, RL. et al. Antagonistic effect of Poria Cocos on ototoxicity of kanamycin in guinea-pigs., CJIM 2, 72–74 (1996). https://doi.org/10.1007/BF02934233 DOI：

Yao-Chun Liu, Gui-Ying Liu, Ru-Lin Liu, et al. Antagonistic effect of Poria Cocos on ototoxicity of kanamycin in guinea-pigs[J]. Chinese Journal of Integrative Medicine, 1996,2(1):72-74. DOI： 10.1007/BF02934233.

摘要

In order to prevent ototoxicity of kanamycin (KM)

the effects of Poria Cocos (PC) on the ototoxicity induced by KM in guinea-pigs was observed by giving the PC decoction to guinea-pigs with comparing the difference in the general intoxicating symptom

Prayer’s reflex (PR) threshold

brainstem auditory evoked potentials (BAEPs) and the absence rate of outer hair cells in the first turn of cochlea. The results suggested that the ototoxicity of KM was retarded by PC decoction. On the 7th day after KM was given

PR threshold of 4

8 kHz in the medicated group and control group were 4.7±1.5 dB

5.7±2.4 dB

2.7± 1.2 dB and 10.5 ± 3.2 dB

12.1±3.7 dB

8.5±2.7 dB respectively. BAEPs threshold on the 13th day after KM was given

raised 22.7 ± 9.7 dB in the PC group and 51.3 ± 14.4 dB in the control group. The absence rate of outer hair cells in the first turn of cochlea were 39.4% and 67.4% respectively. The results suggested that PC might be antagonistic to the ototoxicity of KM in guinea-pigs.

Abstract

In order to prevent ototoxicity of kanamycin (KM)

Prayer’s reflex (PR) threshold

PR threshold of 4

8 kHz in the medicated group and control group were 4.7±1.5 dB

5.7±2.4 dB

2.7± 1.2 dB and 10.5 ± 3.2 dB

12.1±3.7 dB

8.5±2.7 dB respectively. BAEPs threshold on the 13th day after KM was given

关键词

Poria Cocoskanamycinevoked potentialsouter hair cell

Keywords

Poria Cocoskanamycinevoked potentialsouter hair cell

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